A novel nano-hydroxyapatite/synthetic polymer/bone morphogenetic protein-2 composite for efficient bone regeneration

Bal, Zeynep; Korkusuz, Feza; Ishiguro, Hiroyuki; Okada, Rintaro; Kushioka, Junichi; Chijimatsu, Ryota; Kodama, Joe; Tateiwa, Daisuke; Ukon, Yuichiro; Nakagawa, Shinichi; Dede, Eda Çiftci; Gizer, Merve; Korkusuz, Petek; Yoshikawa, Hideki; Kaito, Takashi

doi:10.1016/j.spinee.2021.01.019

Cited by 28 publications

(41 citation statements)

References 34 publications

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“… Surgery-related indexes, which included the surgery time, intraoperative blood loss, postoperative drainage volume, and hospitalization time JOA score: a total of 17 scoring items were included, of which 4 points each for the motor function of four limbs, 2 points each for the sensory function of the body and four limbs, and 3 points for the bladder function. Scores of 0–4 regarded as patients with severe condition had most or completely paralyzed limbs and were unable to take care of themselves; scores of 5–8 regarded as patients with serious condition had partially functional limbs but lost the ability to work; scores of 9–12 regarded as patients with moderate condition had limbs with movement disorders and could do some simple works; and scores of 13–16 regarded as patients with mild condition had slight movement disorders and were essentially able to live and work normally [ 12 , 13 ]. The JOA score was investigated at 1 month ( T 1 ), 2 months ( T 2 ), 3 months ( T 3 ), and 6 months ( T 4 ) after surgery.…”

Section: Methodsmentioning

confidence: 99%

A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare

Zhang

Zhao

Yuan

et al. 2021

Journal of Healthcare Engineering

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With an increasing elderly population worldwide, the incidence of spine degenerative diseases with neck and shoulder pain as the main symptom is rising obviously, which has now become one of the important and difficult problems in sociomedical science. This study was to explore the effects of different ratios of recombinant human bone morphogenetic protein-2 (rhBMP-2) compound to the autogenous bone on cervical interbody fusion. 90 cervical degeneration patients with the need of surgical treatment admitted to our hospital from January 2019 to January 2020 were selected as the research objects and equally divided into group A, group B, and group C according to the order of admission, with 30 cases in each group and the ratios of rhBMP-2 compound to autogenous bone being 2 : 1, 1 : 1, and 1 : 2 respectively, and standard anterior cervical diskectomy and fusion (ACDF) treatment was performed to all patients to compare their surgery-related indexes, the Japanese Orthopaedic Association (JOA) score, the visual analog scale (VAS) score, the effect of cervical interbody fusion, and the postoperative complication rate (CR). Compared with group A and group C, group B achieved the significantly better surgery-related indexes ( P < 0.05 ), significantly higher postoperative JOA scores ( P < 0.05 ), significantly lower postoperative neck and upper limb VAS scores ( P < 0.05 ), significantly better effect of cervical interbody fusion ( P < 0.05 ), and significantly lower postoperative CR ( P < 0.05 ). 1 : 1 is the best ratio of rhBMP-2 compound to the autogenous bone, for it can optimize patients’ perioperative indexes, reduce the postoperative pain, lower the possibility of complications, and improve the effect of cervical interbody fusion, which should be promoted and applied in practice.

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Section: Methodsmentioning

confidence: 99%

A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare

Zhang

Zhao

Yuan

et al. 2021

Journal of Healthcare Engineering

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“…In the presence of COMP, the delivery of 2 μg BMP-2 achieved a similar outcome to 10 μg of BMP-2 alone. Using a similar animal model, it was shown that the implantation of a polylactic acid/polyethene glycol/nano-hydroxyapatite composite scaffold (nHAp/PLA-PEG) allowed a reduction from 10 to 3 µg of rhBMP-2 to promote efficient bone regeneration [ 37 ]. Van der Stok et al developed porous titanium implants by selective laser melting which allowed full regeneration of 6 mm critical-sized femur defects in rats when combined with 3 µg rhBMP-2 delivered with a fibrin gel [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Enhanced BMP-2-Mediated Bone Repair Using an Anisotropic Silk Fibroin Scaffold Coated with Bone-like Apatite

Deininger

Wagner

Heimel

et al. 2021

IJMS

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The repair of large bone defects remains challenging and often requires graft material due to limited availability of autologous bone. In clinical settings, collagen sponges loaded with excessive amounts of bone morphogenetic protein 2 (rhBMP-2) are occasionally used for the treatment of bone non-unions, increasing the risk of adverse events. Therefore, strategies to reduce rhBMP-2 dosage are desirable. Silk scaffolds show great promise due to their favorable biocompatibility and their utility for various biofabrication methods. For this study, we generated silk scaffolds with axially aligned pores, which were subsequently treated with 10× simulated body fluid (SBF) to generate an apatitic calcium phosphate coating. Using a rat femoral critical sized defect model (CSD) we evaluated if the resulting scaffold allows the reduction of BMP-2 dosage to promote efficient bone repair by providing appropriate guidance cues. Highly porous, anisotropic silk scaffolds were produced, demonstrating good cytocompatibility in vitro and treatment with 10× SBF resulted in efficient surface coating. In vivo, the coated silk scaffolds loaded with a low dose of rhBMP-2 demonstrated significantly improved bone regeneration when compared to the unmineralized scaffold. Overall, our findings show that this simple and cost-efficient technique yields scaffolds that enhance rhBMP-2 mediated bone healing.

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“…The development of engineered tissues relies on the development of PLA scaffolds containing bioactive molecules for control of the cellular function (e.g., growth or differentiation factors) or to act on the surrounding tissues (e.g., drugs such as anti‐inflammatory agents or antibiotics) 186 . Recombinant human bone morphogenetic protein‐2 (BMP‐2) has been added to PLA to enhance osteogenesis 166,187,188 . It was reported that PLA scaffolds with Ca 3 (PO 4 ) 2 nanoparticles have good biosafety and tissue compatibility 189 .…”

Section: Effect Of Process Variables On Pla‐based Materialsmentioning

confidence: 99%

Tailoring of advanced poly(lactic acid)‐based materials: A review

Milovanović

Pajnik

Lukić

2021

J of Applied Polymer Sci

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Poly(lactic acid) (PLA) stands out as the most promising biodegradable alternative to conventional petrochemical‐based polymers for manufacturing of high‐performance materials applied in medicine, pharmacy, food, textile, and electronic industry. This review was aimed to present the conventional and up‐to‐date technologies for PLA processing including melt blending and molding, hot melt extrusion, 3D printing, foaming, impregnation, thermally induced phase separation, nano‐ and microparticles preparation, wet and dry spinning processes. In addition, the effect of the processing parameters and polymer characteristics on the properties of the final material was elaborated. Diverse possibilities to tailor properties of PLA‐based materials by variation in polymer characteristics and concentration, solvent selection, drying method, processing pressure and temperature, incorporation of bioactive components, and so on were highlighted. The examples of the relations between processing methods, parameters, and end‐product properties are given for a better understanding of all aspects that need to be perceived for fabrication of PLA‐based materials with required performances.

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A novel nano-hydroxyapatite/synthetic polymer/bone morphogenetic protein-2 composite for efficient bone regeneration

Cited by 28 publications

References 34 publications

A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare

A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare

Enhanced BMP-2-Mediated Bone Repair Using an Anisotropic Silk Fibroin Scaffold Coated with Bone-like Apatite

Tailoring of advanced poly(lactic acid)‐based materials: A review

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