A novel N-chlorotaurine–corticosteroid combination as a preservative-free local disinfectant: Influence on the ciliary beat frequency in vitro

Arnitz, Roland; Ott, Helmut W.; Gstöttner, Michaela; Nagl, Markus; Scholtz, Arne W.; Neher, Andreas

doi:10.1080/00016480500388935

Cited by 9 publications

(4 citation statements)

References 15 publications

(11 reference statements)

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“…The effectiveness of mucociliary clearance is influenced by CBF, the composition of mucus and anatomic structures. 12,[15][16][17] A disturbed mucociliary clearance leads to recurrent episodes of acute and potentially chronic rhinosinusitis, bronchitis, and otitis media. 18,19 Therefore, it is important not to disturb this defense mechanism.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Essential and Fatty Oils on Ciliary Beat Frequency of Human Nasal Epithelial Cells

Neher

Gstöttner

Thaurer³

et al. 2008

American Journal of Rhinology

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Section: Discussionmentioning

confidence: 99%

“…A disturbance of the mucociliary clearance can lead to recurrent sinusitis and in succession to chronic rhinosinusitis. 12 However, data on the consequences of herbal extracts, e.g. , essential and fatty oils, on ciliary beat frequency (CBF) of human nasal epithelial cells are missing in the literature.…”

mentioning

confidence: 99%

Influence of Essential and Fatty Oils on Ciliary Beat Frequency of Human Nasal Epithelial Cells

Neher

Gstöttner

Thaurer³

et al. 2008

American Journal of Rhinology

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“…Since elevated amounts of serum neopterin were reported in patients with acute respiratory tract infections, we speculated that the pteridine compound might be involved in short-term inflammatory events taking place in the surroundings of the nasal mucosa, thus affecting mucociliary clearance. Any disturbance of CBF may result in recurrent episodes of acute infectious processes and may finally lead to permanent events such as chronic rhinosinusitis, otitis media, and bronchitis (12)(13)(14). To date, there is no established practical approach to evaluate CBF in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…In the nasal tract, the effectiveness of mucociliary clearance is predominantly given by ciliary beat frequency (CBF). Any disturbances in mucociliary clearance can lead to recurrent sinusitis potentially evolving into chronic rhinosinusitis, bronchitis, and otitis media (12)(13)(14). Elevated circulating levels of neopterin were found in patients with acute respiratory tract infections (15) and in ambulatory volunteers recruited within 24 h of developing symptoms of common cold (16).…”

Section: Introductionmentioning

confidence: 99%

Influence of Neopterin on Ciliary Beat Frequency of Human Nasal Epithelial Cells in vitro

Neher

Schobersberger²,

Augustijns³

et al. 2008

Pteridines

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Acute infectious diseases of the respiratory tract are regularly associated with increased concentrations of neopterin in serum and/or urine. Most likely, the pteridine compound is not only a marker of an activated cellular immune system but may exert distinct biochemical functions in the process of infections as well. In response to viral contact, macrophages located in the nasal mucosa may represent a source for neopterin in the nasal cavity with potential hazardous effects on ciliary beat frequency (CBF), thus promoting chronic infectious processes. The aim of the present study was to investigate the effects of neopterin at different concentrations (10 nM, 100 nM, and 100 µM) on CBF in human nasal epithelial cells in vitro. Samples were taken from the inferior nasal turbinate and incubated with neopterin dissolved in either aqua destillata or in sodium chloride (0.9%) at the given amounts for 2, 5, 10, and 20 min. In a preliminary set of experiments, neopterin inhibited CBF following the 5 and 10 min. incubation protocol, respectively. However, analyses of pooled data from 28 experiments using sodium chloride (0.9%) as solvent could not confirm these findings: in no setting a significant reduction of CBF was detected at the end of the 20 min. experimental procedure. Therefore, we conclude that neopterin most likely does not affect the mucociliary clearance defense mechanisms in the course of infections of the nasal respiratory tract.

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Effect of N-chlorotaurine mouth rinses on plaque regrowth and plaque vitality

et al. 2008

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The purpose of this 4-day plaque regrowth study was to assess the effect of N-chlorotaurine (NCT) mouth rinses on plaque inhibition and plaque vitality. Eighty volunteers participated in this investigator-blind, randomized, clinical controlled study in parallel groups. No oral hygiene was permitted except rinsing with a 2% or 3% NCT mouth rinse, a positive or a negative control. Primary parameters were the plaque index (Silness and Löe, Acta Odontol Scand, 22:121-135, 1964) and plaque vitality (Netuschil et al., J Clin Periodontol, 16:484-488, 1989) after the final rinse. In addition, another plaque index (Turesky et al., J Periodontol, 41:41-43, 1970), plaque area, and bleeding on probing were recorded. All parameters were taken at baseline and day 5. U test was applied on a 5% error level. No differences in plaque inhibition were found between the two NCT formulations and the negative control. However, a statistically significant reduction of plaque vitality compared to the negative and positive control was observed. Discoloration of the tongue and unpleasant taste were recorded in participants in the NCT groups. NCT mouth rinses did not inhibit plaque regrowth, but they did reduce the vitality of plaque bacteria. Methods of prolonging the substantivity of the NCT mouth rinses should be investigated to enhance the antibacterial properties of these formulations.

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A novel N-chlorotaurine–corticosteroid combination as a preservative-free local disinfectant: Influence on the ciliary beat frequency in vitro

Cited by 9 publications

References 15 publications

Influence of Essential and Fatty Oils on Ciliary Beat Frequency of Human Nasal Epithelial Cells

Influence of Essential and Fatty Oils on Ciliary Beat Frequency of Human Nasal Epithelial Cells

Influence of Neopterin on Ciliary Beat Frequency of Human Nasal Epithelial Cells in vitro

Effect of N-chlorotaurine mouth rinses on plaque regrowth and plaque vitality

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