A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice

Pires, Alana F.; Rodrigues, Natália Velloso Fontenelle Camelo; Soares, Pedro Marcos Gomes; Ribeiro, Ronaldo de Albuquerque; Aragão, Karoline S.; Marinho, Márcia Machado; Silva, Mayara Torquato Lima; Cavada, Benildo S.; Assreuy, Ana Maria Sampaio

doi:10.1007/s00011-015-0889-7

Cited by 21 publications

(12 citation statements)

References 24 publications

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“…Creatine was first reported as an anti-inflammatory by Madan and Khana in 1976 who tested a series of amino acids in a rat model of carrageenan-induced acute inflammation [186]. In this widely-used model for testing anti-inflammatory agents [187–194], carrageenan is injected into the paw, and a number of potent inflammatory mediators are induced both locally and systemically, with maximum edema normally occurring within 3 hours of injection, due to activation of the cyclo-oxgenase pathway [187]. Mediators induced include histamine, bradykinin, serotonin, prostaglandins, tumor necrosis factor-α (TNF-α), interleukin -1 (IL-1), and IL-6 [188–190].…”

Section: Creatine As An Anti-inflammatory Agentmentioning

confidence: 99%

Beyond muscles: The untapped potential of creatine

Riesberg

Weed

McDonald

et al. 2016

International Immunopharmacology

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Creatine is widely used by both elite and recreational athletes as an ergogenic aid to enhance anaerobic exercise performance. Older individuals also use creatine to prevent sarcopenia and, accordingly, may have therapeutic benefits for muscle wasting diseases. Although the effect of creatine on the musculoskeletal system has been extensively studied, less attention has been paid to its potential effects on other physiological systems. Because there is a significant pool of creatine in the brain, the utility of creatine supplementation has been examined in vitro as well as in vivo in both animal models of neurological disorders and in humans. While the data are preliminary, there is evidence to suggest that individuals with certain neurological conditions may benefit from exogenous creatine supplementation if treatment protocols can be optimized. A small number of studies that have examined the impact of creatine on the immune system have shown an alteration in soluble mediator production and the expression of molecules involved in recognizing infections, specifically toll-like receptors. Future investigations evaluating the total impact of creatine supplementation are required to better understand the benefits and risks of creatine use, particularly since there is increasing evidence that creatine may have a regulatory impact on the immune system.

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Section: Creatine As An Anti-inflammatory Agentmentioning

confidence: 99%

Beyond muscles: The untapped potential of creatine

Riesberg

Weed

McDonald

et al. 2016

International Immunopharmacology

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“…Pires et al [48] aimed to investigate the antiinflammatory activity of Lonchocarpus araripensis lectin (LAL). In the dose of 10 mg/kg, LAL reduced carrageenan-induced paw edema in mice by about 77% and also slightly reduced vascular permeability.…”

Section: Anti-inflammatory and Antinociceptive Activities Of Iectinsmentioning

confidence: 99%

Can Plant Lectins be Alternatives to Treat Anxiety and Depressive Disorders?

Lima

Patriota

Albuquerque

et al. 2020

AIR

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Depression and anxiety disorder are the most common mental disorders worldwide and their treatments are combinations of pharmacological and psychotherapeutic approaches. Depression treatment depends largely on a pharmacotherapy that improves the transmission of monoamines in the brain. However, the drugs available have adverse reactions and do not contemplate positively all patients, which stimulates scientific research that seeks new molecules, including from natural sources. Lectins are proteins capable of binding reversibly and non-covalently to specific sugars. For example, it has been reported the antimicrobial, antitumor, antiparasitic, anti-inflammatory and antinociceptive activities of lectins. The ability of some lectins in modulating nociception and inflammation stimulated studies on the possible effects on processes that share some pathways and molecular agents, like depression and anxiety. Lectins isolated from plants showed antidepressant effects, which were demonstrated to be linked to activation of serotonergic, adrenergic, and dopaminergic systems as well as to inhibition of the glutamatergic system and L-arginine–NO–cGMP pathway. In view of their immunomodulatory properties, it is also suggested that lectins can ameliorate the inflammatory framework associated with depression. Anxiolytic effects were also reported and associated with modulation of GABAergic mechanisms, serotonergic system, and NO pathway. It should be taken in account that some lectins induced depressive-like behavior, associated with an neuroinflammatory action, as well anxiogenic action. Thus, it is important to use combinations of batteries for testing anxiety, depression, despair, and anhedonia behaviors in the studies with lectins. The mechanisms by which lectins exactly modulate depression or anxiety frameworks are still unclear but important windows had already been open by researchers and preclinical studies with lectins have indicated these proteins as candidates for alternative or complementary agents in therapies of depression and anxiety disorder.

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“…Plant lectins have shown anti‐inflammatory [16,17] and antinociceptive [18,19] effects. For example, some studies have proposed that lectins can modulate inflammation and pain through interactions of their carbohydrate‐binding domains with glycosylated selectin‐binding sites [20] or δ‐ and κ‐receptors, [21] respectively.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and Anti‐Inflammatory Effects of Saline Extract and Lectin‐Rich Fraction from Microgramma vacciniifolia Rhizome in Mice

Silva

Oliveira

Freitas

et al. 2021

Chemistry & Biodiversity

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Previous studies have characterized a saline extract from Microgramma vacciniifolia rhizome and its lectin (MvRL)‐rich fraction with low acute toxicity. In the present study, we evaluated these preparations for acute toxicity (1,000 mg/kg) and antinociceptive and anti‐inflammatory activities (100–400 mg/kg for the extract and 25–50 mg/kg for the fraction). No signs of toxicity were observed. Both the extract and fraction increased the latency period for nociception in the hot plate assay, decreased writhing induced by acetic acid, and promoted analgesic effects in phases 1 and 2 of the formalin test. The antinociceptive mechanism was attributed to interactions with opioid receptors and K+ ATPase channels. The extract and fraction decreased carrageenan‐induced paw edema in 46.15 % and 77.22 %, respectively, at the highest doses evaluated. Furthermore, the fraction was shown to act on the bradykinin pathway. The ability to decrease leukocyte migration after treatment was also verified in the peritonitis and air pouch models. In exudates collected from air pouches, decreased tumor necrosis factor (TNF)‐α and increased interleukin (IL)‐10 levels were noted. Both the extract and fraction also effectively inhibited the development of granulomatous tissue. In conclusion, the substances investigated in this study can be used for the development of novel therapeutic options for pain and inflammatory processes.

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A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice

Abstract: The novel N-acetyl-D-glucosamine-binding lectin isolated from L. araripensis seeds presents anti-inflammatory effect involving the lectin domain and the inhibition of 5-HT, BK, PGE2, NO, TNF-α and leukocyte rolling and adhesion.

Cited by 21 publications

References 24 publications

Beyond muscles: The untapped potential of creatine

Beyond muscles: The untapped potential of creatine

Can Plant Lectins be Alternatives to Treat Anxiety and Depressive Disorders?

Antinociceptive and Anti‐Inflammatory Effects of Saline Extract and Lectin‐Rich Fraction from Microgramma vacciniifolia Rhizome in Mice

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