“…The tudor domain of SMN, is the essential binding site of SMN to spliceosomal proteins in assisting spliceosomal U small nuclear ribonucleoproteins (U snRNP) assembly and to mediate SMN-oligomerization (Selenko et al, 2001;Brenner et al, 2002;Sun et al, 2005). Mutations in the tudor domain have been shown to be associated with SMA phenotype (Lefebvre Cusco et al, 2004;Sun et al, 2005;Kotani et al, 2007). Gemin2 binding is essential for the formation of SMN complex.…”