A Novel Mushroom Pigment: Isolation and Characterization

Takekuma, Shin‐ichi; Takekuma, Hideko; Matsubara, Yoshiharu; Inaba, Kazuaki; Yoshida, Z.

doi:10.1021/ja00098a071

Cited by 17 publications

(19 citation statements)

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“…A new type of cofactor is present in PYP: p -coumaric acid (Hoff et al, 1994a;Baca et al, 1994). With some other newly identified chromophores, such as stentorin ( Tao et al, 1993), blepharismin (Gioffré et al, 1993), flavin (Galland and Senger, 1991) and indolone ( Takekuma et al, 1994), p-coumaric acid shares the chemical entity of the aromatic ring. This leads us to distinguish a third class of chromophores (see Table 1 and Fig.…”

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confidence: 99%

Photobiology of microorganisms: how photosensors catch a photon to initialize signalling

Hellingwerf

Hoff

Crielaard

1996

Molecular Microbiology

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Photobiological processes are relevant for microorganisms for energy generation, protection against excess and/or damaging radiation, and for signalling. In this review we give an overview of the knowledge on the functioning of photosensors in microorganisms, with special emphasis on the conformational changes that lead to signal generation and transduction. Light is absorbed by specific chromophores, which are tuned, by their proteinaceous environment, to function optimally. These chromophores belong to three classes: tetrapyrroles, polyenes and aromatics. The chemical structure of photosensing pigment/protein complexes has been resolved for many of the photobiological processes that have a characteristic sensitivity in the visible and infrared part of the spectrum of (solar) radiation. However, knowledge about the structure of photoreceptors responsible for several physiologically well‐characterized photoresponses to UV‐ and blue light is still lacking. For a limited number of phototransduction processes, the details of light‐induced signal transfer are beginning to be understood in atomic detail. This applies particularly to two photosensors involved in phototactic responses in bacteria: sensory rhodopsin I (SR‐I) from Halobacterium salinarium and photoactive yellow protein (PYP) from Ectothiorhodospira halophila. The SR‐I system is of special interest because the transducer accepting the signal from SR‐I was recently identified as Htr‐I, a homologue of the methyl‐accepting chemotaxis proteins which have been characterized in Escherichia coli. PYP, on the other hand, may be the first photosensor to actually reveal all relevant details of the kinetics, thermodynamics, and molecular motion of light‐induced signal generation, through an understanding of how the photo‐isomerization of the chromophore forces the sensor protein into the signalling state. Here we compare these photosensors and discuss common themes in the initiation of photosensory signal transduction in microorganisms in terms of the molecular properties of photosensors and their signalling state.

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confidence: 99%

Photobiology of microorganisms: how photosensors catch a photon to initialize signalling

Hellingwerf

Hoff

Crielaard

1996

Molecular Microbiology

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“…Takekuma et al have reported that the protein produces oxygen molecules from water on light irradiation. This phenomenon implies that o (i) this mushroom has a photosynthetic function in which the chromoprotein plays an important role (Takekuma et al, 1994). The aim of the present study is to reveal the structurefunction relationship of the chromoprotein with the novel photosynthetic mechanism.…”

Section: Introductionmentioning

confidence: 93%

“…This mushroom includes a pink chromoprotein with an absorption spectrum maximum at 496 nm. This protein has a pigment molecule, 3H-indol-3-one (I) which occupies a part of the active site (Takekuma, Takekuma, Matsubara, Inaba & Yoshida, 1994) and has three kinds of metals, Zn, Fe, and Cu. 3H-indol-3-one has an absorption maximum at 456nm in methanol and a bathochromic shift occurs in the chromoprotein.…”

Section: Introductionmentioning

confidence: 99%

Crystallization and preliminary crystallographic studies of pink color chromoprotein fromPleurotus salmoneostramineusL. Vass.

Shibata

Gohow²,

Inoue³

et al. 1997

Acta Crystallogr D Biol Crystallogr

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“…54,55 The edible mushroom Pleurotus salmoneostramineus has a bright pink coloration and is referred to as the pink oyster mushroom; this vibrant coloration has been attributed to 3-indolone (34). 56 A collection of N-glycosylated indoles (35−38) was isolated from the fruiting bodies of Cortinarius brunneus. 57 Investigation into the activity of these molecules via root growth assays revealed no significant auxin-like activity, 57 inferring that 35 (the N-glucoside of IAA) has an endogenous role as an inactive storage or detoxification product of the growth hormone, similar to the role of IAA-O-glucose (39) in plant tissues.…”

Section: ■ Introductionmentioning

confidence: 99%

“…79 The mushroom Hericium coralloides has interesting fruiting bodies that are reminiscent of off-white coral. 80 This species produces the indole alkaloid corallocin C (56). Although no antiproliferative activity was identified against a variety of cancer cell lines, 56 was found to stimulate neurotrophin expression in human 1321N1 astrocytes; approximately 30% of neural PC12 cells differentiated when exposed to a medium containing 19.6 μM 56.…”

Section: ■ Introductionmentioning

confidence: 99%