A novel multichannel surface plasmon resonance biosensor

Homola, Jiřı́; Lu, Hongbo; Nenninger, Garet G.; Dostálek, Jakub; Yee, Sinclair S.

doi:10.1016/s0925-4005(01)00648-7

Cited by 128 publications

(72 citation statements)

References 15 publications

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“…12b) [34]. This approach has been demonstrated to have capacity to discriminate effects occurring in the proximity of the sensor surface (specific binding, non-specific adsorption) from those occurring in the whole medium (interfering background refractive index fluctuations) which is a prerequisite for advanced referencing [35]. Referencing approaches have been studied [36,37].…”

Section: Instrumentationmentioning

confidence: 99%

Present and future of surface plasmon resonance biosensors

Homola

2003

Analytical and Bioanalytical Chemistry

2,051

1,026

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Surface plasmon resonance (SPR) biosensors are optical sensors exploiting special electromagnetic waves-surface plasmon-polaritons-to probe interactions between an analyte in solution and a biomolecular recognition element immobilized on the SPR sensor surface. Major application areas include detection of biological analytes and analysis of biomolecular interactions where SPR biosensors provide benefits of label-free real-time analytical technology. This paper reviews fundamentals of SPR affinity biosensors and discusses recent advances in development and applications of SPR biosensors.

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Section: Instrumentationmentioning

confidence: 99%

Present and future of surface plasmon resonance biosensors

Homola

2003

Analytical and Bioanalytical Chemistry

2,051

1,026

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“…The most effective approach to the solution of the problem is two-plasmon spectroscopy when two plasmons are excited at different wavelengths [2,[4][5][6][7][8]. Different techniques for excitation have been applied [4][5][6][7][8] and each of them has specific drawbacks.…”

Section: Introductionmentioning

confidence: 99%

Plasmon Modes Management

2011

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A new plasmonic structure based on bimetallic layer is proposed. We analyze the structure and show that bimetallic film plays a crucial role in the management of surface plasmons. The roll of the buffer is discussed, as well. Up to three surface plasmons can be excited simultaneously in the structure. Two of plasmons can be used for two-plasmon spectroscopy. The third plasmon can be used for controlling the temperature of the structure.

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“…Such a sensor configuration provides thorough probing of surface processes with surface plasmons with different field distributions. This enables a more accurate quantification of the biomolecular interactions on the sensor surface [38]. A combination of a FIA system with the IAsys system (Affinity sensors, MA), which is based on the resonant mirror technology (RM), is also presented by Bracewell et al [39].…”

Section: Affinity Sensors (Spr Rif and Rm)mentioning

confidence: 99%

Optical sensor systems for bioprocess monitoring

2003

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Bioreactors are closed systems in which microorganisms can be cultivated under defined, controllable conditions that can be optimized with regard to viability, reproducibility, and product-oriented productivity. To drive the biochemical reaction network of the biological system through the desired reaction optimally, the complex interactions of the overall system must be understood and controlled. Optical sensors which encompass all analytical methods based on interactions of light with matter are efficient tools to obtain this information. Optical sensors generally offer the advantages of noninvasive, nondestructive, continuous, and simultaneous multianalyte monitoring. However, at this time, no general optical detection system has been developed. Since modern bioprocesses are extremely complex and differ from process to process (e.g., fungal antibiotic production versus mammalian cell cultivation), appropriate analytical systems must be set up from different basic modules, designed to meet the special demands of each particular process. In this minireview, some new applications in bioprocess monitoring of the following optical sensing principles will be discussed: UV spectroscopy, IR spectroscopy, Raman spectroscopy, fluorescence spectroscopy, pulsed terahertz spectroscopy (PTS), optical biosensors, in situ microscope, surface plasmon resonance (SPR), and reflectometric interference spectroscopy (RIF).

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A novel multichannel surface plasmon resonance biosensor

Cited by 128 publications

References 15 publications

Present and future of surface plasmon resonance biosensors

Present and future of surface plasmon resonance biosensors

Plasmon Modes Management

Optical sensor systems for bioprocess monitoring

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