A novel multi-frequency trans-endothelial electrical resistance (MTEER) sensor array to monitor blood-brain barrier integrity

Recent Advances of Biosensor-Integrated Organ-on-a-Chip Technologies for Diagnostics and Therapeutics

“…Real-time monitoring of the BBB integrity was performed using MTEER measurement with a machine learning algorithm. Linear discriminant analysis (LDA) classifier with a forward sequential feature selection (SFS) method was used as a machine learning algorithm [Reprinted from ref . Sensors and Actuators B: Chemical , Vol.…”

Biosensors Integration in Blood–Brain Barrier-on-a-Chip: Emerging Platform for Monitoring Neurodegenerative Diseases

“…More recently, integrated electrodes and multifrequency TEER with machine learning algorithms have been incorporated in multilayered microfluidic platform using PMMA ( Figure 1 A). 19 …”

“…(A) PMMA layers in stack conformation with TEER system included. Reproduced with permission from ( 19 ). Copyright 2021 Elsevier.…”

“…PDMS layers were placed between two glass slides, and Ag was sputtered for electrodes fabrication. More recently, integrated electrodes and multifrequency TEER with machine learning algorithms have been incorporated in multilayered microfluidic platform using PMMA (Figure A) …”

Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research

“…By combining multi-band frequency measurement techniques and machine learning algorithms, the novel TEER system successfully monitored the formation, opening, and reclosure of the BBB in a non-invasive manner. 20 The μBBB with the capability to present higher human relevance can be used to validate and improve complex enhanced BBB penetration and disease treatment strategies, such as chemotactic synthetic vesicles and RNA interference therapy, resulting in a powerful platform for brain-related disease research and drug screening. 21,22 Fig.…”