A Novel Molecule: 1‐(2,6 Dichlorobenzyl)‐4‐(2‐(2‐4‐hydroxybenzylidene)hydrazinyl)pyridinium Chloride and its Interaction with DNA

Karasakal, Ayça; Parlar, Sülünay; Alptüzün, Vildan; Çetin, Arif E.; Topkaya, Seda Nur

doi:10.1002/elan.202060597

Cited by 2 publications

(3 citation statements)

References 31 publications

(20 reference statements)

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“…In literature, there are many studies which guanine oxidation signal decreases after drug and DNA interaction. However, the decrease or increase redox signals of drug molecules are infrequent (31,32).…”

Section: Discussionmentioning

confidence: 99%

“…In another study, the interaction between pyridine derivate molecule and DNA was analyzed electrochemically. According to the results, it was observed that the oxidation signal of the pyridine derivative increased after its interaction with DNA, while the oxidation signal of guanine decreased (31). The path for most possible reaction of DHP molecule to occur with OH radicals was analyzed.…”

Section: Discussionmentioning

confidence: 99%

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Candidate drug molecule-DNA interaction and molecular modelling of candidate drug molecule

Karasakal

Gürkan

Parlar³

2022

Journal of Health Sciences and Medicine

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Aim: 1,4-dihydropyridine derivative, 1-(3-phenyl propyl)-4-(2-(2-hydroxybenzylidene) hydrazone)-1,4-dihydropyridine (abbreviated as DHP) was synthesized as potential agent for Alzheimer’s disease which is a progressive neurodegenerative brain disorder affecting millions of elderly people. With this study, the electrochemical properties of DHP were investigated and its interaction with DNA was analyzed by differential pulse voltammetry (DPV) and cyclic voltammetry (CV) measurements. In addition, this study aims to determine degradation mechanism of the DHP molecule by Density-functional theory (DFT) in gas and in aqueous phase. Material and Method: Experimental conditions such as immobilization time, the effect of the scan rate, concentration, and the effect of pH were optimized. The method was validated according to validation parameters such as range, precision, linearity, limit of detection (LOD), limit of quantitation (LOQ) and inter/intraday. Results: Linearity study for the calibration curve of DNA and DHP with DPV was calculated in the calibration range 10-100 µg/mL. The LOD and LOQ values were calculated as 3 and 10 µg/mL and intra-day and inter-day repeatability (RSD %) were 1.85 and 3.64 µg/mL, respectively. After the DHP-DNA interaction, the oxidation currents of guanine decreased as a proof of interaction. The activation energy of the most possible path of reaction was calculated, and their thermodynamically most stable state was determined in gas phase. Conclusion: We developed to improve a sensitive, fast and easy detection process for determination of interaction between DHP and DNA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Candidate drug molecule-DNA interaction and molecular modelling of candidate drug molecule

Karasakal

Gürkan

Parlar³

2022

Journal of Health Sciences and Medicine

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“…They identified minor groove binding and unwinding of the DNA structure after prolonged exposure [ 35 ]. Furthermore, DNA biosensors were used to observe the toxicity of drugs in DNA structure and to assess their interaction [ 36 , 37 , 38 ]. Many DNA biosensors have been used to monitor the antioxidant properties of foodstuffs [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Ethanol and NaCl-Induced Gold Nanoparticle Aggregation Toxicity toward DNA Investigated with a DNA/GCE Biosensor

Blaškovičová

Vyskočil

Augustín

et al. 2023

Sensors

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Engineered nanomaterials are becoming increasingly common in commercial and consumer products and pose a serious toxicological threat. Exposure of human organisms to nanomaterials can occur by inhalation, oral intake, or dermal transport. Together with the consumption of alcohol in the physiological environment of the body containing NaCl, this has raised concerns about the potentially harmful effects of ingested nanomaterials on human health. Although gold nanoparticles (AuNPs) exhibit great potential for various biomedical applications, there is some inconsistency in the case of the unambiguous genotoxicity of AuNPs due to differences in their shape, size, solubility, and exposure time. A DNA/GCE (DNA/glassy carbon electrode) biosensor was used to study ethanol (EtOH) and NaCl-induced gold nanoparticle aggregation genotoxicity under UV light in this study. The genotoxic effect of dispersed and aggregated negatively charged gold nanoparticles AuNP1 (8 nm) and AuNP2 (30 nm) toward salmon sperm double-stranded dsDNA was monitored by cyclic and square-wave voltammetry (CV, SWV). Electrochemical impedance spectroscopy (EIS) was used for a surface study of the biosensor. The aggregation of AuNPs was monitored by UV-vis spectroscopy. AuNP1 aggregates formed by 30% v/v EtOH and 0.15 mol·L−1 NaCl caused the greatest damage to the biosensor DNA layer.

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A Novel Molecule: 1‐(2,6 Dichlorobenzyl)‐4‐(2‐(2‐4‐hydroxybenzylidene)hydrazinyl)pyridinium Chloride and its Interaction with DNA

Cited by 2 publications

References 31 publications

Candidate drug molecule-DNA interaction and molecular modelling of candidate drug molecule

Candidate drug molecule-DNA interaction and molecular modelling of candidate drug molecule

Ethanol and NaCl-Induced Gold Nanoparticle Aggregation Toxicity toward DNA Investigated with a DNA/GCE Biosensor

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