A novel molecularly imprinted electrochemical sensor based on double sensitization by MOF/CNTs and Prussian blue for detection of 17β-estradiol

Duan, Dingding; Si, Xiaojing; Ding, Yaping; Li, Li; Ma, Guohong; Zhang, Lu; Jian, Bingyu

doi:10.1016/j.bioelechem.2019.04.014

Cited by 56 publications

(29 citation statements)

References 34 publications

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“…Therefore, the E2 determination with high sensitivity and selectivity is extremely relevant to control the impacts on health and the environment. There are many methods that have been developed for E2 detection such as immunological methods [9], chromatographic methods [10–14] and electrochemical methods [15–20]. The electrochemical methods are rapid and inexpensive and generally can be directly applied in the analysis of various classes of compounds [21].…”

Section: Introductionmentioning

confidence: 99%

Sensitive Determination of 17β‐Estradiol using a Magneto Sensor Based on Magnetic Molecularly Imprinted Polymer

et al. 2020

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The analysis of 17β‐estradiol with high sensitivity and selectivity is extremely relevant to control the impacts that this compound can cause on health and the environment. Thus, we describe the development and application of a magneto carbon paste electrode based on magnetic molecularly imprinted polymer (MCPE‐MMIP) for determination of 17β‐estradiol. The analyte adsorbed on the MMIP was immobilized on the electrode surface by magnetic capture. The morphological and structural characterization of the obtained MMIP suggests that the material was effectively synthesized. MCPE‐MMIP showed an improvement in the sensitivity for 17β‐estradiol detection when compared to electrode configurations in the absence of this material. The optimum conditions (0.10 mol L−1 phosphate buffer pH 7.0) were reached by differential pulse adsorptive stripping voltammetry (DPAdSV), in which the method presented linearity ranged from 0.06 to 175 μmol L−1 with limits of detection and quantification of 0.02 and 0.06 μmol L−1, respectively. The proposed sensor was applied effectively in the analysis of 17β‐estradiol in river water and raw milk samples, exhibiting excellent recovery values (between 96.20 and 104 %), which were confirmed by HPLC analysis.

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Section: Introductionmentioning

confidence: 99%

Sensitive Determination of 17β‐Estradiol using a Magneto Sensor Based on Magnetic Molecularly Imprinted Polymer

et al. 2020

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“…The molecularly imprinted sensor exhibited a linear range, between 3.2 fM and 3.2 µM. Recently, a polypyrrole-based MIP for 17β-estradiol has been integrated into an MOF, which was modified with Prussian Blue [125]. Together with carbon nanotubes, PB increased the electrical conductivity, which resulted in an extremely high sensitivity with an LOD of 6.19 fM.…”

Section: Redox-inactive Analytesmentioning

confidence: 99%

How Reliable Is the Electrochemical Readout of MIP Sensors?

Yarman

Scheller

2020

Sensors

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Electrochemical methods offer the simple characterization of the synthesis of molecularly imprinted polymers (MIPs) and the readouts of target binding. The binding of electroinactive analytes can be detected indirectly by their modulating effect on the diffusional permeability of a redox marker through thin MIP films. However, this process generates an overall signal, which may include nonspecific interactions with the nonimprinted surface and adsorption at the electrode surface in addition to (specific) binding to the cavities. Redox-active low-molecular-weight targets and metalloproteins enable a more specific direct quantification of their binding to MIPs by measuring the faradaic current. The in situ characterization of enzymes, MIP-based mimics of redox enzymes or enzyme-labeled targets, is based on the indication of an electroactive product. This approach allows the determination of both the activity of the bio(mimetic) catalyst and of the substrate concentration.

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“…The MIP sensor was assembled by first modifying a GCE with an aluminum-based metal–organic framework (MOF) containing in the dispersion media CNT to improve MOFs electronic properties. Further modification was performed by electrodeposition of a Prussian blue film and polypyrrole (PPy) as the imprinting polymer [ 128 ]. Specially in biosensors and MIP design, the importance of CNT structures is evident in the ability to increase load capacity, biocompatibility, and chemical stability, which seem more relevant features than electrochemical signal enhancement.…”

Section: Nanostructured Carbon-based (Bio)sensors For Pharmaceuticmentioning

confidence: 99%

“…One example is the application of molecularly imprinted polymers. Though also fastidious, graphene- [ 84 ] and MWCNT- [ 122 , 128 ] based sensors that employed this technology achieved good sensitivities on the level of sub-nanomolar concentrations.…”

Section: Overall Comparison Between Reported Nanostructured Carbonmentioning

confidence: 99%

“…Tap water was analyzed as real sample with no traces of diclofenac being found [117]. It seems evident that the most sensitive (bio)sensors are based in highly specific recognition elements such as MIP [122,128] or biological entities involving aptamers [118] and antibodies [104,116,125]. In this way, the lowest LOD (6.2 × 10 −9 µmol L −1 ) corresponded to a MIP sensor developed for 17β-estradiol detection in environmental waters.…”

Section: Carbon Nanotubesmentioning

confidence: 99%

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Application of Nanostructured Carbon-Based Electrochemical (Bio)Sensors for Screening of Emerging Pharmaceutical Pollutants in Waters and Aquatic Species: A Review

et al. 2020

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Pharmaceuticals, as a contaminant of emergent concern, are being released uncontrollably into the environment potentially causing hazardous effects to aquatic ecosystems and consequently to human health. In the absence of well-established monitoring programs, one can only imagine the full extent of this problem and so there is an urgent need for the development of extremely sensitive, portable, and low-cost devices to perform analysis. Carbon-based nanomaterials are the most used nanostructures in (bio)sensors construction attributed to their facile and well-characterized production methods, commercial availability, reduced cost, high chemical stability, and low toxicity. However, most importantly, their relatively good conductivity enabling appropriate electron transfer rates—as well as their high surface area yielding attachment and extraordinary loading capacity for biomolecules—have been relevant and desirable features, justifying the key role that they have been playing, and will continue to play, in electrochemical (bio)sensor development. The present review outlines the contribution of carbon nanomaterials (carbon nanotubes, graphene, fullerene, carbon nanofibers, carbon black, carbon nanopowder, biochar nanoparticles, and graphite oxide), used alone or combined with other (nano)materials, to the field of environmental (bio)sensing, and more specifically, to pharmaceutical pollutants analysis in waters and aquatic species. The main trends of this field of research are also addressed.

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A novel molecularly imprinted electrochemical sensor based on double sensitization by MOF/CNTs and Prussian blue for detection of 17β-estradiol

Cited by 56 publications

References 34 publications

Sensitive Determination of 17β‐Estradiol using a Magneto Sensor Based on Magnetic Molecularly Imprinted Polymer

Sensitive Determination of 17β‐Estradiol using a Magneto Sensor Based on Magnetic Molecularly Imprinted Polymer

How Reliable Is the Electrochemical Readout of MIP Sensors?

Application of Nanostructured Carbon-Based Electrochemical (Bio)Sensors for Screening of Emerging Pharmaceutical Pollutants in Waters and Aquatic Species: A Review

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