A novel modified CPE using CE-Zno-Lapis lazuli nanocomposite as a sensitive electrochemical sensor for the determination of anti-cancer drug of etoposide

Soltani, Nasrin; Khayatkashani, Maryam; Ebrahimian, Javad; Tavakkoli, Nahid; Rezaei, Asma; Ryadh, Abrar; Salavati-Niasari, Masoud

doi:10.1016/j.jallcom.2023.171900

Cited by 5 publications

(1 citation statement)

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“…Scientists have made numerous endeavors to combat cancer. Chemotherapy stands as the primary approach in cancer treatment, relying on the utilization of anti-cancer drugs [1,2]. This treatment method can be associated with various side effects.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Nanosensor for the Simultaneous Determination of Anticancer Drugs Epirubicin and Topotecan Using UiO-66-NH2/GO Nanocomposite Modified Electrode

Tajik,

Shams,

Beitollahi

et al. 2024

Biosensors

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In this work, UiO-66-NH2/GO nanocomposite was prepared using a simple solvothermal technique, and its structure and morphology were characterized using field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD). An enhanced electrochemical sensor for the detection of epirubicin (EP) was proposed, which utilized a UiO-66-NH2/GO nanocomposite-modified screen-printed graphite electrode (UiO-66-NH2/GO/SPGE). The prepared UiO-66-NH2/GO nanocomposite improved the electrochemical performance of the SPGE towards the redox reaction of EP. Under optimized experimental conditions, this sensor demonstrates a remarkable limit of detection (LOD) of 0.003 µM and a linear dynamic range from 0.008 to 200.0 µM, providing a highly capable platform for sensing EP. Furthermore, the simultaneous electro-catalytic oxidation of EP and topotecan (TP) was investigated at the UiO-66-NH2/GO/SPGE surface utilizing differential pulse voltammetry (DPV). DPV measurements revealed the presence of two distinct oxidation peaks of EP and TP, with a peak potential separation of 200 mV. Finally, the UiO-66-NH2/GO/SPGE sensor was successfully utilized for the quantitative analysis of EP and TP in pharmaceutical injection, yielding highly satisfactory results.

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Section: Introductionmentioning

confidence: 99%