“…Knowing the solubility of drugs in scCO 2 is crucial for evaluating the feasibility of separation methods based on supercritical fluids and determining the optimum operational conditions. − Many models have been reported to mathematically represent the solubility behavior. − In this study, various semiempirical models were used to correlate the experimental solubility of alprazolam in scCO 2 . In the case of the binary system (alprazolam/scCO 2 ), the following correlations were considered: where a 0 – a 2 are the adjustable parameters of correlations.…”
This research investigated the solubility of alprazolam in supercritical carbon dioxide (scCO 2 ) with the addition of ethanol as a cosolvent. The solubility was examined at various pressures (ranging from 120 to 300 bar) and temperatures (ranging from 308 to 338 K). The solubility of alprazolam in scCO 2 ranged from 0.027 × 10 −4 to 0.632 × 10 −4 . When ethanol was used as a cosolvent, the solubility increased to a range of 0.157 × 10 −4 to 1.660 × 10 −4 (with 1 mol % ethanol) and 0.449 × 10 −4 to 3.167 × 10 −4 (with 3 mol % ethanol). Under the specified operating parameters, the highest solubility of alprazolam was achieved in the ternary system (with 3 mol % ethanol) at 120 bar and 338 K. This solubility was 16.63 times higher than when using pure scCO 2 under the same circumstances. Several semiempirical correlations were used to compute the solubility of alprazolam in supercritical carbon dioxide. These models yielded similar average absolute relative deviations ranging from 7.0 to 8.40%. The findings demonstrated the superiority of the Kumar−Johnston model in binary systems (with an average absolute relative deviation of 7.0%) and the Garlapati−Madras model in ternary systems (with an average absolute relative deviation of 6.19%) compared to alternative models.
“…Knowing the solubility of drugs in scCO 2 is crucial for evaluating the feasibility of separation methods based on supercritical fluids and determining the optimum operational conditions. − Many models have been reported to mathematically represent the solubility behavior. − In this study, various semiempirical models were used to correlate the experimental solubility of alprazolam in scCO 2 . In the case of the binary system (alprazolam/scCO 2 ), the following correlations were considered: where a 0 – a 2 are the adjustable parameters of correlations.…”
This research investigated the solubility of alprazolam in supercritical carbon dioxide (scCO 2 ) with the addition of ethanol as a cosolvent. The solubility was examined at various pressures (ranging from 120 to 300 bar) and temperatures (ranging from 308 to 338 K). The solubility of alprazolam in scCO 2 ranged from 0.027 × 10 −4 to 0.632 × 10 −4 . When ethanol was used as a cosolvent, the solubility increased to a range of 0.157 × 10 −4 to 1.660 × 10 −4 (with 1 mol % ethanol) and 0.449 × 10 −4 to 3.167 × 10 −4 (with 3 mol % ethanol). Under the specified operating parameters, the highest solubility of alprazolam was achieved in the ternary system (with 3 mol % ethanol) at 120 bar and 338 K. This solubility was 16.63 times higher than when using pure scCO 2 under the same circumstances. Several semiempirical correlations were used to compute the solubility of alprazolam in supercritical carbon dioxide. These models yielded similar average absolute relative deviations ranging from 7.0 to 8.40%. The findings demonstrated the superiority of the Kumar−Johnston model in binary systems (with an average absolute relative deviation of 7.0%) and the Garlapati−Madras model in ternary systems (with an average absolute relative deviation of 6.19%) compared to alternative models.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.