A novel modeling and simulation technique of photo–thermal interactions between lasers and living biological tissues undergoing multiple changes in phase

DUA, R; Chakraborty, Suman

doi:10.1016/j.compbiomed.2004.02.005

Cited by 51 publications

(10 citation statements)

References 10 publications

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“…11 The photothermal impact of lasers is a critical parameter that needs to be determined in order to evaluate the effectiveness and laser safety of these systems especially with high power consumption (50, [12][13][14][15] ∼60, 16 and 300 mW). 17 Laser has photothermal interactions with tissues 18 caused by the temperature rise due to laser irradiation, which may cause damage to the tissues, 19 including protein denaturation, increased mitochondrial membrane permeability, and ultimately vaporization. 20 Temperature increase can also lead to changes in cellular metabolism, electrical membrane capacitance, and in the long term, can lead to necrosis.…”

Section: Introductionmentioning

confidence: 99%

Thermal impact of near-infrared laser in advanced noninvasive optical brain imaging

2016

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The propagation of laser light in human tissues is an important issue in functional optical imaging. We modeled the thermal effect of different laser powers with various spot sizes and different head tissue characteristics on neonatal and adult quasirealistic head models. The photothermal effect of near-infrared laser (800 nm) was investigated by numerical simulation using finite-element analysis. Our results demonstrate that the maximum temperature increase on the brain for laser irradiance between 0.127 (1 mW) and [Formula: see text] (100 mW) at a 1 mm spot size, ranged from 0.0025°C to 0.26°C and from 0.03°C to 2.85°C at depths of 15.9 and 4.9 mm in the adult and neonatal brain, respectively. Due to the shorter distance of the head layers from the neonatal head surface, the maximum temperature increase was higher in the neonatal brain than in the adult brain. Our results also show that, at constant power, spot size changes had a lesser heating effect on deeper tissues. While the constraints for safe laser irradiation to the brain are dictated by skin safety, these results can be useful to optimize laser parameters for a variety of laser applications in the brain. Moreover, combining simulation and adequate in vitro experiments could help to develop more effective optical imaging to avoid possible tissue damage.

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Section: Introductionmentioning

confidence: 99%

Thermal impact of near-infrared laser in advanced noninvasive optical brain imaging

2016

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“…In forward and side scatter graph, it was observed that after PTT, population showed shift in both FSC-A and SSC-A i.e. reduction in size and increase in granularity respectively, which further validate the apoptotic nature of the cells’ death after photothermal treatment at mild hyperthermia 22 , 23 (Supplementary Fig. S10c ).…”

Section: Resultsmentioning

confidence: 59%

Enhanced EPR directed and Imaging guided Photothermal Therapy using Vitamin E Modified Toco-Photoxil

Chauhan

Ravichandran

Gupta

et al. 2018

Sci Rep

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Herein we report synthesis, characterization and preclinical applications of a novel hybrid nanomaterial Toco-Photoxil developed using vitamin E modified gold coated poly (lactic-co-glycolic acid) nanoshells incorporating Pgp inhibitor d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as a highly inert and disintegrable photothermal therapy (PTT) agent. Toco-Photoxil is highly biocompatible, physiologically stable PTT material with an average diameter of 130 nm that shows good passive accumulation (2.3% ID) in solid tumors when delivered systemically. In comparison to its surface modified counterparts such as IR780-Toco-Photoxil, FA-Toco-Photoxil or FA-IR780-Toco-Photoxil accumulation are merely ~0.3% ID, ~0.025% ID and ~0.005% ID in folate receptor (FR) negative and positive tumor model. Further, Toco-Photoxil variants are prepared by tuning the material absorbance either at 750 nm (narrow) or 915 nm (broad) to study optimal therapeutic efficacy in terms of peak broadness and nanomaterial’s concentration. Our findings suggest that Toco-Photoxil tuned at 750 nm absorbance is more efficient (P = 0.0097) in preclinical setting. Toco-Photoxil shows complete passiveness in critical biocompatibility test and reasonable body clearance. High tumor specific accumulation from systemic circulation, strong photothermal conversion and a very safe material property in body physiology makes Toco-Photoxil a superior and powerful PTT agent, which may pave its way for fast track clinical trial in future.

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“…Extremes of temperature into the freezing and burning ranges are useful in surgical procedures for selective killing and/or removal of target tissues. For example in hyperthermia raising the temperature into the burning ranges 41-44 • C, [10]. Human skin will not melt but burn, superficial burns occur at 37.8 • C, deep dermal burns at 41.9 • C and full skin thickness burns at 47.9 • C, [11].…”

Section: Four Novel Different Methodsmentioning

confidence: 99%

“…With a specified surface heating u(t), the actual temperature response T(z, t) = (z, t) + T(z, 0) can be computed in the whole depth of the tissue z ∈ [0, L] by (10) and (17). Here, we propose a robust procedure to solve the inverse problem of Pennes' equation.…”

Section: Definitionmentioning

confidence: 99%

Optimal Control for Pennes' Bioheat Equation

Malek¹,

Abbasi²

2014

Asian Journal of Control

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The problem of Pennes' bioheat boundary control through a skin with its inner medium kept at a constant steady‐state temperature where the outer surface subjected to conductive condition is solved by different methods. Analytical and mild solutions of Pennes' boundary control problem yield a discrete optimization problem for temperature profile at the specific depth point as well as temperature profile at all points of the skin in the final time. The pointwise optimal control problem has been solved by discretized form of the unconstrained optimization problem using analytical solution for Pennes' boundary control problem. The analytical solution has been used to solve the optimal control problems via an unconstrained/constrained optimization in Methods I and II. In Method III first, Pennes' boundary control problem is solved using mild solution by strongly continuous semigroup theory. Then, nonlinear optimization problem with linear constraints is proposed to calculate the corresponding piecewise optimal control function. All methods, have been applied to a homogeneous tissue. Mathematical simulation is done to show the optimal controls for the related states when minimum effort is used.

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A novel modeling and simulation technique of photo–thermal interactions between lasers and living biological tissues undergoing multiple changes in phase

Cited by 51 publications

References 10 publications

Thermal impact of near-infrared laser in advanced noninvasive optical brain imaging

Thermal impact of near-infrared laser in advanced noninvasive optical brain imaging

Enhanced EPR directed and Imaging guided Photothermal Therapy using Vitamin E Modified Toco-Photoxil

Optimal Control for Pennes' Bioheat Equation

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