2005
DOI: 10.1016/j.compbiomed.2004.02.005
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A novel modeling and simulation technique of photo–thermal interactions between lasers and living biological tissues undergoing multiple changes in phase

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Cited by 51 publications
(10 citation statements)
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“…11 The photothermal impact of lasers is a critical parameter that needs to be determined in order to evaluate the effectiveness and laser safety of these systems especially with high power consumption (50, [12][13][14][15] ∼60, 16 and 300 mW). 17 Laser has photothermal interactions with tissues 18 caused by the temperature rise due to laser irradiation, which may cause damage to the tissues, 19 including protein denaturation, increased mitochondrial membrane permeability, and ultimately vaporization. 20 Temperature increase can also lead to changes in cellular metabolism, electrical membrane capacitance, and in the long term, can lead to necrosis.…”
Section: Introductionmentioning
confidence: 99%
“…11 The photothermal impact of lasers is a critical parameter that needs to be determined in order to evaluate the effectiveness and laser safety of these systems especially with high power consumption (50, [12][13][14][15] ∼60, 16 and 300 mW). 17 Laser has photothermal interactions with tissues 18 caused by the temperature rise due to laser irradiation, which may cause damage to the tissues, 19 including protein denaturation, increased mitochondrial membrane permeability, and ultimately vaporization. 20 Temperature increase can also lead to changes in cellular metabolism, electrical membrane capacitance, and in the long term, can lead to necrosis.…”
Section: Introductionmentioning
confidence: 99%
“…In forward and side scatter graph, it was observed that after PTT, population showed shift in both FSC-A and SSC-A i.e. reduction in size and increase in granularity respectively, which further validate the apoptotic nature of the cells’ death after photothermal treatment at mild hyperthermia 22 , 23 (Supplementary Fig. S10c ).…”
Section: Resultsmentioning
confidence: 59%
“…Extremes of temperature into the freezing and burning ranges are useful in surgical procedures for selective killing and/or removal of target tissues. For example in hyperthermia raising the temperature into the burning ranges 41-44 • C, [10]. Human skin will not melt but burn, superficial burns occur at 37.8 • C, deep dermal burns at 41.9 • C and full skin thickness burns at 47.9 • C, [11].…”
Section: Four Novel Different Methodsmentioning
confidence: 99%
“…With a specified surface heating u(t), the actual temperature response T(z, t) = (z, t) + T(z, 0) can be computed in the whole depth of the tissue z ∈ [0, L] by (10) and (17). Here, we propose a robust procedure to solve the inverse problem of Pennes' equation.…”
Section: Definitionmentioning
confidence: 99%