A novel model mouse for type 2 diabetes mellitus with early onset and persistent hyperglycemia

Ohno, Tamio; Miyasaka, Yuki; YOSHIDA, Kanta; Kobayashi, Misato; Horio, Fumihiko; Yokoi, Norihide; Mizuno, Masashi; Ikegami, Hiroshi

doi:10.1538/expanim.22-0061

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…This is caused by a spontaneous mutation of the agouti yellow gene. This strain is designated as NSY.B6-Tyr + ,A y [123].…”

Section: Genetic Modelsmentioning

confidence: 99%

Animal Models in Diabetic Research—History, Presence, and Future Perspectives

Pandey,

Chmelir,

Chottova Dvorakova

2023

Biomedicines

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Diabetes mellitus (DM) is a very serious disease, the incidence of which has been increasing worldwide. The beginning of diabetic research can be traced back to the 17th century. Since then, animals have been experimented on for diabetic research. However, the greatest development of diabetes research occurred in the second half of the last century, along with the development of laboratory techniques. Information obtained by monitoring patients and animal models led to the finding that there are several types of DM that differ significantly from each other in the causes of the onset and course of the disease. Through different types of animal models, researchers have studied the pathophysiology of all types of diabetic conditions and discovered suitable methods for therapy. Interestingly, despite the unquestionable success in understanding DM through animal models, we did not fully succeed in transferring the data obtained from animal models to human clinical research. On the contrary, we have observed that the chances of drug failure in human clinical trials are very high. In this review, we will summarize the history and presence of animal models in the research of DM over the last hundred years. Furthermore, we have summarized the new methodological approaches, such as “organ-on-chip,” that have the potential to screen the newly discovered drugs for human clinical trials and advance the level of knowledge about diabetes, as well as its therapy, towards a personalized approach.

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“…This is caused by a spontaneous mutation of the agouti yellow gene. This strain is designated as NSY.B6-Tyr + ,A y [123].…”

Section: Genetic Modelsmentioning

confidence: 99%

Animal Models in Diabetic Research—History, Presence, and Future Perspectives

Pandey,

Chmelir,

Chottova Dvorakova

2023

Biomedicines

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“…A substrain of obese type of NSY mice with yellow fur was obtained by cross breeding with agouti Ay mice 102 . This strain has a good fertility and does not display inter‐male aggression, making them useful as a new model for type 2 diabetes with early onset and persistent hyperglycemia 103 .…”

Section: Animal Models For Type 2 Diabetesmentioning

confidence: 99%

Contribution of animal models to diabetes research: Its history, significance, and translation to humans

Yagihashi

2023

J of Diabetes Invest

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Diabetes mellitus is still expanding globally and is epidemic in developing countries. The combat of this plague has caused enormous economic and social burdens related to a lowered quality of life in people with diabetes. Despite recent significant improvements of life expectancy in patients with diabetes, there is still a need for efforts to elucidate the complexities and mechanisms of the disease processes to overcome this difficult disorder. To this end, the use of appropriate animal models in diabetes studies is invaluable for translation to humans and for the development of effective treatment. In this review, a variety of animal models of diabetes with spontaneous onset in particular will be introduced and discussed for their implication in diabetes research.

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