A novel mixture of curcumin paste and prednisolone for treating oral lichen planus: A case controlled comparative study

Naik, Shantala R; Gupta, Prashant; Ashok, L; Khaitan, Tanya; Shukla, Anjani Kumar

doi:10.4103/jiaomr.jiaomr_171_19

Cited by 2 publications

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“…The present study indicated that curcumin had no significant effect on the improvement of pain in patients with OLP after 4 and 12 weeks; however, the 2-week treatment period showed a significant effect on reducing the pain of patients. In the studies by Naik et al [ 37 ] and Chainani-Wu et al [ 33 ], pain in patients with OLP was reduced after 2 weeks. However, consistent with the current study, Nosratzehi et al [ 4 ] and Thomas et al [ 32 ] after a 12-week follow-up and Kia et al [ 11 , 22 ] and Amirchaghmaghi et al [ 18 ] after a 4-week follow-up showed a weak and non-significant effect on pain improvement.…”

Section: Discussionmentioning

confidence: 99%

Effects of Curcumin on the treatment of oral lichen planus symptoms: a systematic review and meta-analysis study

Moayeri,

Rajabi,

Mohammadi

et al. 2024

BMC Oral Health

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Background and objectives Oral lichen planus (OLP) is a relatively common chronic T-cell–mediated disease that can cause significant pain, particularly in its erosive or ulcerative forms. This study aimed to examine the therapeutic impact of curcumin on symptoms of OLP. Materials and methods This meta-analysis was performed according to the PRISMA guidelines. All related English documents indexed in electronic databases (including PubMed, Web of Science, Scopus, Embase, Wiley, Cochrane, and ProQuest databases [updated to August 15, 2023]) were retrieved. Data were double-extracted into a predefined worksheet, and quality analysis was performed using the Joanna Briggs Institute (JBI) scale. We carried out meta-analyses, and the random effects model was used to estimate the differences in erythema, lesion size, and pain between the curcumin control groups. Results The search identified 289 studies, of which 10 were found to meet the inclusion criteria. The overall findings of the meta-analysis revealed that curcumin did not have a significant effect on erythema of OLP (standardized mean difference [SMD] = -0.14; 95% CI, -0.68 to 0.40; P = 0.61; I2 = 57.50%), lesion size of OLP (SMD = -0.15; 95% CI, -0.45 to 0.15; P = 0.33; I2 = 28.42%), and pain of OLP (SMD = -0.38; 95% CI, -0.97 to 0.22; P = 0.22; I2 = 86.60%). However, subgroup analysis based on treatment duration indicated that 2-week treatment duration was significantly associated with a reduction in OLP pain (n = 3; SMD = -1.21; 95% CI, -2.19 to -0.23; P = 0.01). Conclusions Curcumin had no significant effect on erythema, lesion size, and pain of OLP compared to the control groups. However, subgroup analysis revealed that curcumin was more effective in reducing pain in non-randomized trials and in trials with a treatment duration of 2 weeks.

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Section: Discussionmentioning

confidence: 99%

Effects of Curcumin on the treatment of oral lichen planus symptoms: a systematic review and meta-analysis study

Moayeri,

Rajabi,

Mohammadi

et al. 2024

BMC Oral Health

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Effectiveness of Curcumin in Reducing Self-Rated Pain-Levels in the Orofacial Region: A Systematic Review of Randomized-Controlled Trials

Sterniczuk

Rossouw

Michelogiannakis

et al. 2022

IJERPH

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The aim was to systematically review randomized controlled trials (RCTs) that assessed the effectiveness of curcumin in reducing self-rated pain levels in the orofacial region (OFR). The addressed focused question was “Is curcumin effective in reducing self-rated pain levels in the OFR?”. Indexed databases (PubMed (National Library of Medicine), Scopus, EMBASE, MEDLINE (OVID), and Web of Science) were searched up to and including February 2022 using different keywords. The inclusion criteria were (a) original studies (RCTs) in indexed databases; and (b) studies assessing the role of curcumin in the management of pain in the OFR. The risk of bias was assessed using the Cochrane risk of bias tool. The pattern of the present systematic review was customized to primarily summarize the pertinent information. Nineteen RCTs were included. Results from 79% of the studies reported that curcumin exhibits analgesic properties and is effective in reducing self-rated pain associated with the OFR. Three studies had a low risk of bias, while nine and seven studies had a moderate and high risk of bias, respectively. Curcumin can be used as an alternative to conventional therapies in alleviating pain in the OFR. However, due to the limitations and risk of bias in the aforementioned studies, more high-quality RCTs are needed.

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A novel mixture of curcumin paste and prednisolone for treating oral lichen planus: A case controlled comparative study

Cited by 2 publications

References 0 publications

Effects of Curcumin on the treatment of oral lichen planus symptoms: a systematic review and meta-analysis study

Effects of Curcumin on the treatment of oral lichen planus symptoms: a systematic review and meta-analysis study

Effectiveness of Curcumin in Reducing Self-Rated Pain-Levels in the Orofacial Region: A Systematic Review of Randomized-Controlled Trials

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