A novel microfluidic enzyme-organocatalysis combination strategy for ring-opening copolymerizations of lactone, lactide and cyclic carbonate

Huang, Weijun; Zhu, Ning; Liu, Yihuan; Wang, Jian; Zhong, Jun; Sun, Qiang; Sun, Tao; Hu, Xin; Fang, Zheng; Guo, Kai

doi:10.1016/j.cej.2018.09.033

Cited by 31 publications

(27 citation statements)

References 49 publications

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“…For example, this biocatalyst, the 1,5,7-triazabicyclo [4.4.0] dec-5-ene biocatalyst and an organocatalyst were employed in the polymerizations of ε-caprolactone, δ-valerolactone, L-lactide and trimethylene carbonate. 384 N435 did not work using L-lactide while the organocatalyst had low activity using caprolactone. The enzyme and organocatalyst were combined in an assembled tandem microreactor system, producing different well-defined triblock copolymers.…”

Section: Lewatit Vp Oc 1600mentioning

confidence: 99%

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Novozym 435: the “perfect” lipase immobilized biocatalyst?

Ortíz

Ferreira

Barbosa

et al. 2019

Catal. Sci. Technol.

454

360

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Section: Lewatit Vp Oc 1600mentioning

confidence: 99%

“…The enzyme and organocatalyst were combined in an assembled tandem microreactor system, producing different well-defined triblock copolymers. 384…”

Section: Lewatit Vp Oc 1600mentioning

confidence: 99%

Novozym 435: the “perfect” lipase immobilized biocatalyst?

Ortíz

Ferreira

Barbosa

et al. 2019

Catal. Sci. Technol.

454

360

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“…Focusing specifically on microreactors, the recent publication of Huang et al is worth mentioning, which presents the development of a new microfluidic biocatalysisorganocatalysis combination strategy for ring-opening copolymerizations of lactone, lactide and cyclic carbonate. 101 Among other significant improvements, the authors state a shortened overall polymerization time (<40 min) and high monomer conversions (>95%). Žnidaršič-Plazl and co-workers theoretically and experimentally characterized a micro packed-bed reactor (μPBR) with immobilized Candida antarctica lipase B (Novozym 435) in their well-presented study.…”

Section: Reaction Chemistry and Engineering Reviewmentioning

confidence: 99%

The rise of continuous flow biocatalysis – fundamentals, very recent developments and future perspectives

2020

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“…[115][116][117] The spatial-temporal control and high-efficiency of mass/heat transfer properties of continuousflow chemistry enable high level control of the architectures of polymers. [114,118,119] Guironnet and co-workers [120] presented a scalable strategy to synthesize bottlebrush polymers with programmable shape, size, and composition. They also prepared bottlebrush polymers by using automated continuous-flow systems.…”

Section: Challenge 1: Development Of Novel Synthetic Strategies To Janusmentioning

confidence: 99%

Design, Synthesis, and Self‐Assembly of Janus Bottlebrush Polymers

Chen

Zhu

et al. 2020

Macromol. Rapid Commun.

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in solution, [28-30] and at the interfaces [31,32] features the unique microstructures and varied applications (Figure 1C). Janus bottlebrush polymers are a class of special molecular brushes, which have two incompatible side chains on the same repeating unit of the backbone. [33] "Janus" is the god in ancient Roman religion and myth with two faces looking to the past and the future. [34] In scientific community, the phrases containing Janus, such as "Janus nanoparticles," [35-38] "Janus beads," [39,40] and "Janus polymerization," [41-43] indicate something consisting of counterparts. [44-46] The design of Janus bottlebrush polymers was inspired by Janus particles. [35,47-49] The characteristic of Janus bottlebrush polymers is that the repeating unit of the backbone possesses two immiscible side chains. [50-52] Core-shell bottlebrush polymers with block copolymers as the side chains are usually not Janus-type unless the block side chains are unsymmetrical. [6] An emerging Janus core-shell bottlebrush polymer has been developed by transferring the side chains from homo polymers to two different block copolymers. [53] Design, synthesis, and self-assembly of Janus bottlebrush polymers have arouse much interest in polymer chemistry and material science. [54,55] In general, Janus bottlebrush polymers could be prepared via backbone-first [50] (grafting-to and graftingfrom) or side-chain-first [56] (grafting-through) strategy. Most of Janus bottlebrush polymers were reported via grafting-through approach. Macromonomers are first designed and subsequently polymerizations occur to form the backbone. [23] Backbonefirst route also allows for the synthesis of Janus bottlebrush polymers by using combined grafting-to and grafting-from approach. [57] The special unsymmetrical architectures enable Janus bottlebrush polymers to achieve ideal phase separation in bulk, [58,59] in solution, [52] and at the interface. [32] The preorganized interface can promote self-assembly process and avoid the distorted phase separation. [32,33] The self-assembly of Janus bottlebrush polymers achieves small domain size and tunable bulk property, [58,59] which is challenging for the traditional linear or bottlebrush polymers. [60,61] Therefore, Janus bottlebrush polymers have great potential applications in nanolithography, [58] photonic crystals, [62] biomedicine, [53] surfactants, [63] etc. The big families of bottlebrush polymers have been nicely reviewed by Grubbs and co-workers, [64] Müllner and coworkers, [65-67] Rzayev and co-workers, [7] Verduzco and coworkers, [6] and Matyjaszewski and co-workers [2]. As a young but significant class, Janus bottlebrush polymers have achieved remarkable advances in recent years. Therefore, this review attempts to focus on Janus bottlebrush polymers, covering Janus bottlebrush polymers are a class of special molecular brushes, which have two immiscible side chains on the repeating unit of the backbone. The characteristic architectures of Janus bottlebrush polymers enable unique selfassembly properties and br...

show abstract

A novel microfluidic enzyme-organocatalysis combination strategy for ring-opening copolymerizations of lactone, lactide and cyclic carbonate

Cited by 31 publications

References 49 publications

Novozym 435: the “perfect” lipase immobilized biocatalyst?

Novozym 435: the “perfect” lipase immobilized biocatalyst?

The rise of continuous flow biocatalysis – fundamentals, very recent developments and future perspectives

Design, Synthesis, and Self‐Assembly of Janus Bottlebrush Polymers

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