A novel method to measure regional muscle blood flow continuously using NIRS kinetics information

Nioka, Shoko; Kime, Ryotaro; Sunar, Ulaş; Im, Joohee; İzzetoğlu, Meltem; Zhang, Jun; Alacam, Burak; Chance, Britton

doi:10.1186/1476-5918-5-5

Cited by 31 publications

(9 citation statements)

References 51 publications

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“…During arterial occlusion, we observed an approximate equivalent rise of RHb (maximum concentration change of 0.0085 AE 0.0024 mM∕DPF) and fall of OHb (minimum concentration change of −0.0057 AE 0.0044 mM∕DPF), which follow trends similar to other studies. 29 For 3 ms exposure, the 1∕K 2 S values dropped to an average of 82.1 AE 4.0% compared to baseline values, during the occlusion period, which is similar to that reported in temporal DSCA, 20 and the average recovery of 1∕K 2 S values after occlusion was 109.1 AE 0.8%, much less than the value from shorter exposure times. For one subject, venous occlusion was ran to observe blood oxygenation and blood flow for different occlusion types (Fig.…”

Section: Resultssupporting

confidence: 81%

Simultaneous blood flow and blood oxygenation measurements using a combination of diffuse speckle contrast analysis and near-infrared spectroscopy

et al. 2016

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A combined diffuse speckle contrast analysis (DSCA)-near-infrared spectroscopy (NIRS) system is proposed to simultaneously measure qualitative blood flow and blood oxygenation changes in human tissue. The system employs an optical switch to alternate two laser sources at two different wavelengths and a CCD camera to capture the speckle image. Therefore, an optical density can be measured from two wavelengths for NIRS measurements and a speckle contrast can be calculated for DSCA measurements. In order to validate the system, a flow phantom test and an arm occlusion protocol for arterial and venous occlusion were performed. Shorter exposure times (<1 ms ) show a higher drop (between 50% and 66%) and recovery of 1/K²S values after occlusion (approximately 150%), but longer exposure time (3 ms) shows more consistent hemodynamic changes. For four subjects, the 1/K²S values dropped to an average of 82.1±4.0% during the occlusion period and the average recovery of 1/K²S values after occlusion was 109.1±0.8% . There was also an approximately equivalent amplitude change in oxyhemoglobin (OHb) and deoxyhemoglobin (RHb) during arterial occlusion (max RHb=0.0085±0.0024 mM/DPF, min OHb=-0.0057±0.0044 mM/DPF). The sensitivity of the system makes it a suitable modality to observe qualitative hemodynamic trends during induced physiological changes.

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Section: Resultssupporting

confidence: 81%

Simultaneous blood flow and blood oxygenation measurements using a combination of diffuse speckle contrast analysis and near-infrared spectroscopy

et al. 2016

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“…Along with the wide use of NIRS in clinical studies (Greisen 2006) this type of diagnostic is becoming more significant for sport science and physiology (Boushel and Piantadosi 2000;Quaresima et al 2003;Pereira et al 2007). A summary of different methodological aspects, measurement parameters, and instrumentation can be found in Quaresima et al 2003and Wolf et al 2007. Nioka et al (2006 pointed out that NIRS can provide good information as a method of non-invasive monitoring of blood flow.…”

Section: Introductionmentioning

confidence: 96%

Evaluation of changes in the haemoglobin of skin and muscle tissue of the calf, as induced by topical application of a nonivamide/nicoboxil cream

Warnecke

Wendt

Winkler

et al. 2014

Can. J. Physiol. Pharmacol.

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Topical agents like nonivamide and nicoboxil induce hyperaemisation and increase cutaneous blood flow and temperature. This study aimed to determine the effects of a nonivamide-nicoboxil cream on haemodynamics in the skin and calf muscle, via optical spectroscopy, discriminating between the changes for skin and muscle. Optical spectroscopy was applied in the visible (VIS) and near-infrared (NIR) wavelength range. The study determined the effect of the cream on changes in oxygenated (ΔoxyHb) and deoxygenated (ΔdeoxyHb) haemoglobin in skin and muscle, as well as on tissue oxygen saturation (SO2) in the skin of 14 healthy subjects. The left and right calves of the subjects were either treated with nonivamide-nicoboxil cream or were sham-administered. NIR spectroscopy allows noninvasive in-vivo examination of the oxygenation of human skeletal muscle. Topical administration of the nonivamide-nicoboxil cream significantly increased the concentration of oxygenated haemoglobin and tissue oxygen saturation in the skin, as well as the concentration of oxygenated haemoglobin in the muscle of the treated legs after 15 min, but with stronger and faster effects in the skin. The topical application of the nonivamide-nicoboxil cream increased blood flow in (smaller vessels of) the skin and muscle tissues.

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“…NIRS has been used to measure changes in skeletal muscle oxygen levels during exercise (Chance et al 1992; Wolf et al 2007; Hamaoka et al 2007; Ferrari et al 1997), skeletal muscle blood flow (van Beekvelt et al 2001b; DeBlasi et al 1994; Nioka et al 2006), and skeletal muscle oxygen consumption (van Beekvelt et al 2001b; Malagoni et al 2010). A NIRS method has been developed that measures mitochondrial capacity by assessing the rate of recovery of oxygen consumption after exercise using multiple arterial occlusions (Motobe M 2004; Buchheit et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Near-infrared assessments of skeletal muscle oxidative capacity in persons with spinal cord injury

et al. 2013

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Purpose After spinal cord injury (SCI) skeletal muscle decreases in size, increases in intramuscular fat, and has potential declines in mitochondrial function. Reduced mitochondrial function has been linked to the development of metabolic disease. The aim of this study was to measure mitochondrial function in persons with SCI using near-infrared spectroscopy (NIRS). Methods Oxygen consumption of the vastus lateralis muscle was measured with NIRS during repeated short-duration arterial occlusions in nine able-bodied (AB) and nine persons with motor complete SCI. Skeletal muscle oxidative capacity (Vmax) was evaluated with two approaches: (1) rate constant of the recovery of oxygen consumption after exercise and (2) extrapolated maximum oxygen consumption from a progressive work test. Results Vmax as indicated by the rate constant (k) from the recovery kinetics test was lower in SCI compared to AB participants (k: SCI: 0.7 ± 0.3 vs. AB: 1.9 ± 0.4 min−1; p < 0.001). Time constants were SCI: 91.9 ± 37.8 vs. AB: 33.6 ± 8.3 sec. Vmax from the progressive work test approached a significant difference between groups (SCI: 5.1 ± 2.9 vs. AB: 9.8 ± 5.5%Hb-Mb/sec; p = 0.06). Conclusions NIRS measurements of Vmax suggest a deficit of 50-60% in participants with SCI compared to AB controls, consistent with previous studies using 31P-MRS and muscle biopsies. NIRS measurements can assess mitochondrial capacity in people with SCI, and potentially other injured/diseased populations.

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A novel method to measure regional muscle blood flow continuously using NIRS kinetics information

Cited by 31 publications

References 51 publications

Simultaneous blood flow and blood oxygenation measurements using a combination of diffuse speckle contrast analysis and near-infrared spectroscopy

Simultaneous blood flow and blood oxygenation measurements using a combination of diffuse speckle contrast analysis and near-infrared spectroscopy

Evaluation of changes in the haemoglobin of skin and muscle tissue of the calf, as induced by topical application of a nonivamide/nicoboxil cream

Near-infrared assessments of skeletal muscle oxidative capacity in persons with spinal cord injury

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