A Novel Method to Improve Neurological Disease Surveillance

Michael, Benedict; Dodd, Katherine; Geleta, David; Payne, Terry R.; Solomon, Tom

doi:10.1136/jnnp-2014-309236.41

Cited by 1 publication

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“…Clinical data suggest that nerves in the lungs can be affected by different diseases; for instance, lung cancer can spread to the nerve trunks. Respiratory dysfunctions resulting from neurological diseases are well described (Michael et al, 1999). New studies also highlight the roles of lung-innervating neurons in controlling immune cell activity in asthma, rhinitis, chronic obstructive pulmonary disorder, and lung infections (Blake et al, 2019;De Virgiliis and Di Giovanni, 2020).…”

Section: Frontiers In Molecular Biosciencesmentioning

confidence: 99%

Schwann cells in the normal and pathological lung microenvironment

Shurin,

Wheeler,

Shurin

et al. 2024

Front. Mol. Biosci.

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The lungs are a key organ in the respiratory system. They are regulated by a complex network of nerves that control their development, structure, function, and response to various pathological stimuli. Accumulating evidence suggests the involvement of a neural mechanism in different pathophysiological conditions in the lungs and the development and progression of common respiratory diseases. Lung diseases are the chief source of death globally. For instance, lung cancer is the second most commonly diagnosed malignancy, after prostate cancer in men and breast cancer in women, and is the most lethal cancer worldwide. However, although airway nerves are accepted as a mechanistically and therapeutically important feature that demands appropriate emphasizing in the context of many respiratory diseases, significantly less is known about the role of the neuroglial cells in lung physiology and pathophysiology, including lung cancer. New data have uncovered some cellular and molecular mechanisms of how Schwann cells, as fundamental components of the peripheral nervous system, may regulate lung cancer cells’ survival, spreading, and invasiveness in vitro and in vivo. Schwann cells control the formation and maintenance of the lung cancer microenvironment and support metastasis formation. It was also reported that the number of lung cancer-associated Schwann cells correlates with patients’ survival. Different factors secreted by Schwann cells, including microRNA, are known to sharpen the lung cancer environment by regulating the tumor-neuro-immune axis. Further clinical and experimental studies are required to elucidate the detailed role of Schwann cells in creating and maintaining pulmonary tumor-neuro-immune axis, which will advance our understanding of the pathogenesis of lung cancer and may inform therapeutic hypotheses aiming neoplasms and metastases in the lung.

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Section: Frontiers In Molecular Biosciencesmentioning

confidence: 99%