Abstract:ionizing radiation (LDIR) induce angiogenesis in vivo by activating the receptor 2 of VEGF but, there is no evidence that it enhances neovascularization in vascular occlusive disease, our overall objective. Methods: We used a mouse model of hind-limb ischemia. In 22-wk-old C57BL/6 mice, the distal external iliac and femoral arteries and veins were ligated and excised. After that, the mice were irradiated or not with 0.3 Gy using a linear accelerator x-rays photon beam. The laser-Doppler perfusion imager (MoorL… Show more
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