A Novel Method for High‐Throughput Reduction of Compounds through Automated Sequential Injection into a Continuous‐Flow Microfluidic Reactor

“…The general protocol is as follows: the stainless steel CatCart filled with heterogeneous catalyst such as 5% Pd/C, Raney Nickel or Wilkinson's Rh(TPP) 3 Cl is pretreated by passing the eluent through the device by an HPLC-pump for 2 min. After setting up desired reaction parameters (by using the touch screen interface), such as the flow rate of reagents, pressure of hydrogen, and temperature, the eluent is changed to the reaction mixture and the product is collected to sample vials for analytical measurements within minutes.…”

Section: Experiments Using H-cubementioning

confidence: 99%

Automated Technology for Performing Flow-Chemistry at Elevated Temperature and Pressure

Kovács¹,

Jones²,

Niesz³

et al. 2007

JALA: Journal of the Association for Laboratory Automation

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Over the past few years, a series of novel microfluidic-based instruments were developed by ThalesNano, Inc. to carry out dangerous and difficult to perform chemical reactions in a safe and fast manner, resulting in superior performance to what commercial batch reactors could provide. Importance of microfluidic devices is continuously raising, as seen there are more and more publications, applications and devices in this field expanding the borders of chemistry. Furthermore, as one of the main advantages for pharmaceutical applications, these new revolutionary reactors allow the fast, on-the-fly mode optimization of different heterogeneous reactions in a high-throughput fashion. The heart of the reactor systems is the actual reactor bed, called the CatCart system. CatCarts allow easy handling of heterogeneous catalyst or immobilized reagents without further purification of products. In addition, the shoe-box size of these reactors makes them available from laboratories to industrial applications.

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“…Jones reported consistency in conversion over a series of nitroindole reductions [6] and in the reduction of a library of nitro-group containing molecules through the H-Cube ® with the Tecan liquid handler [7]. Ley discussed the effect of temperature on the catalyst activity [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

Bryan¹,

Wernick²,

Hein³

et al. 2011

Beilstein J. Org. Chem.

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SummaryThe performance of the ThalesNano H-Cube®, a commercial packed bed flow hydrogenator, was evaluated in the context of small scale reaction screening and optimization. A model reaction, the reduction of styrene to ethylbenzene through a 10% Pd/C catalyst bed, was used to examine performance at various pressure settings, over sequential runs, and with commercial catalyst cartridges. In addition, the consistency of the hydrogen flow was indirectly measured by in-line UV spectroscopy. Finally, system contamination due to catalyst leaching, and the resolution of this issue, is described. The impact of these factors on the run-to-run reproducibility of the H-Cube® reactor for screening and reaction optimization is discussed.

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A Novel Method for High‐Throughput Reduction of Compounds through Automated Sequential Injection into a Continuous‐Flow Microfluidic Reactor

Cited by 31 publications

References 14 publications

Managing Hazardous Reactions and Compounds in Process Chemistry

Managing Hazardous Reactions and Compounds in Process Chemistry

Automated Technology for Performing Flow-Chemistry at Elevated Temperature and Pressure

Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

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