A novel method for banking dental pulp stem cells

Gioventù, Silvia; Andriolo, Gabriella; Bonino, Ferruccio; Frasca, Stefania; Lazzari, Lorenza; Montelatici, Elisa; Santoro, Franco; Rebulla, Paolo

doi:10.1016/j.transci.2012.06.005

Cited by 52 publications

(37 citation statements)

References 45 publications

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“…Several studies indicate that banking with the cryopreservation of the third molar can store dental pulp stem cells for regenerative medicine. 28,29 Moreover, it is reported that dental pulp including dental pulp progenitor cells can be obtained by nonsurgical dental root canal procedures without tooth extraction. 30 Therefore, this study focused on the use of dental pulp for facial nerve regeneration therapy.…”

Section: Discussionmentioning

confidence: 99%

Electrophysiologic and Functional Evaluations of Regenerated Facial Nerve Defects with a Tube Containing Dental Pulp Cells in Rats

Sasaki¹,

Matsumine

Watanabe

et al. 2014

Plastic and Reconstructive Surgery

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Section: Discussionmentioning

confidence: 99%

Electrophysiologic and Functional Evaluations of Regenerated Facial Nerve Defects with a Tube Containing Dental Pulp Cells in Rats

Sasaki¹,

Matsumine

Watanabe

et al. 2014

Plastic and Reconstructive Surgery

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“…Various studies showed that, as DPSCs, SHEDs have not only interesting in vitro and in vivo TR potential, being able to repair bone, cartilage, blood vessels and adipose tissue, but also a higher proliferation rate, increased population doubling and stemness properties for longer periods, compared to DPSCs and BM-MSCs 28-31 17, 32, 33 . These properties make them a simple, straightforward and convenient source of stem cells for treatment of many current or potential diseases of the pediatric patient, with minimal or no trauma [32][33][34] .…”

Section: Deciduous Teeth and Oral Mucosa: Two Promising Reservoir Of mentioning

confidence: 99%

Human exfoliated deciduous teeth and oral mucosa: promising applications in tissue regeneration

Cristaldi¹,

Mauceri²,

Tomasello³

et al. 2018

J Pediatrics & Pediatr Med

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In the last three decades, the constantly increasing need for therapies, efficiently preventing and/or treating human diseases, has raised the interest in Regenerative Medicine (RM). RM is based on employing mesenchymal stem cells (MSCs), that showed to have great proliferation, self-renewal and multilineage differentiation potential, in vitro as well as in vivo. The opportunity of an accessible, painless and low-cost reservoir of MSCs constitutes the first important step of a successful regenerative therapy to include in the current clinical practice. Oral cavity has recently demonstrated to contain different MSCs niches: dental pulp from permanent and deciduous teeth, periodontal ligament, dental follicle, apical papilla and mucosa. MSCs from dental pulp of deciduous teeth, naturally lost in pediatric age, and the oral mucosa have shown to be easily harvested and to have a promising regenerative potential. Thus, the aim of the paper is to review the potentialities of human exfoliated deciduous teeth stem cells (SHEDs) and oral mucosa stem cells (OMSCs) in RM, with the purpose of their use as accessible source of MSCs for the future of pediatric patient.

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“…human serum or human serum albumin) have also been developed and positively tested over recent years to increase stem cells' cryopreservation safety and their clinical utility [ 77 , 78 ]. Along with those attempts to reduce or substitute DMSO in storage protocols, Gioventù et al [ 79 ] tested the possibility of cryoconserving DPSCs inside the whole tooth. In their opinion, avoiding the purifi cation step will reduce the possibility of stemness loss due to the cryopreservation period; moreover, it will reduce the initial cost and assist the efforts required to set up a DSC bank [ 79 ].…”

Section: Stem Cells and "Good Practice"mentioning

confidence: 99%