A Novel Metabolic Score for Insulin Resistance and Symptomatic Intracranial Hemorrhage in Ischemic Stroke Patients After Endovascular Thrombectomy

Chen, Shuaiyu; E, Yan; Zhang, Xiaohao; Wei, Bin; Wang, Siyu; Xu, Zhaohan; Gong, Pei; Xie, Yi; Qin, Chunhua; Zhang, Yingdong

doi:10.2147/ndt.s394438

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Considering the practicality of its measurements and the pathophysiological correlations with components of metabolic syndrome and IR, a predictive role of METS-IR has also been highlighted in endothelial dysfunction and inflammatory [ 11 , 12 ]. Moreover, accumulative evidence suggested that METS-IR was related to cardiometabolic disorders and cardiovascular diseases (CVDs) [ 13 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study

Tian,

Chen,

et al. 2023

Cardiovasc Diabetol

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Background The risk of cardiovascular disease (CVD) depended on the magnitude and exposure duration of insulin resistance (IR). This study aimed to investigate the associations of cumulative metabolic score for IR (cumMETS-IR) with incident CVD, and to further explore the modulated effects of time course of METS-IR accumulation. Methods We enrolled 47,270 participants without CVD and underwent three examinations during 2006–2010 from the Kailuan study. CumMETS-IR from 2006 to 2010 were calculated as the mean values of METS-IR between consecutive examinations multiplying by time intervals between visits. Time course of METS-IR accumulation was calculated as the slope of METS-IR versus time. Hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD risk were calculated with multivariable-adjusted Cox regressions. Results During a median follow-up of 10.99 years, we identified 3184 cases of incident CVD. The risk of incident CVD increased with increasing cumMETS-IR (HR, 1.77; 95% CI 1.58–1.98 for the Q4 versus Q1 group), exposure duration (HR, 1.60; 95% CI 1.45–1.77 for 6 years versus 0 years), and cumulative burden (HR, 1.49; 95% CI 1.37–1.61 for burden ≥ 0 versus < 0). A positive slope was associated with 14% higher risk of CVD (HR, 1.14; 95% CI 1.07–1.22). When combining cumMETS-IR and slope, those with cumMETS-IR ≥ median (142.78) and slope ≥ 0 had the highest risk of CVD (HR,1.38; 95% CI 1.25–1.53). Conclusions The risk of CVD increased with elevated cumMETS-IR and an increasing trend over time, emphasizing the importance of maintaining optimal METS-IR levels across life span.

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Section: Introductionmentioning

confidence: 99%

Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study

Tian,

Chen,

et al. 2023

Cardiovasc Diabetol

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An innovative metabolic index for insulin resistance correlates with early neurological deterioration following intravenous thrombolysis in minor acute ischemic stroke patients

Wang,

Hu,

et al. 2024

Heliyon

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Association between metabolic score for insulin resistance and clinical outcomes: insights from the Tehran lipid and glucose study

Tamehri Zadeh,

Cheraghloo,

Masrouri

et al. 2024

Nutr Metab (Lond)

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Background We aimed to assess the relationship between Metabolic Score for Insulin Resistance (METS-IR) and the incidence of coronary heart disease (CHD), stroke, mortality, diabetes, hypertension, and chronic kidney disease (CKD) in a population from the Middle East and North Africa (MENA) region. Method Individuals aged ≥ 20 years were enrolled. Cox proportional hazards regression models were applied to assess the association between METS-IR and incident CHD, stroke, all-cause mortality, diabetes, hypertension, and CKD. Results Over a median follow-up period of 9–18 years, 1080 (10.6%), 267 (2.6%), 1022 (9.6%), 1382 (16.4%), 2994 (58.5%), and 2002 (23.0%) CHD, stroke, all-cause mortality, diabetes, hypertension, and CKD events occurred, respectively. Compared to the lowest quartile (reference), the hazard ratios (HR) associated with the highest quartile of METS-IR were 1.527 (95% confidence interval [CI]: 1.208–1.930, P for trend 0.001), 1.393 (0.865–2.243, > 0.05), 0.841 (0.682–1.038, > 0.05), 3.277 (2.645–4.060, < 0.001), 1.969 (1.752–2.214, < 0.001), and 1.020 (0.874–1.191, > 0.05) for CHD, stroke, all-cause mortality, diabetes, hypertension, and CKD, respectively. METS-IR, as a continuous variable, was significantly associated with the risk of incident CHD [HR, 95% CI: 1.106, 1.034–1.184], diabetes [1.524, 1.438–1.616], and hypertension [1.321, 1.265–1.380]. These associations were also independent of metabolic syndrome (METS) and remained unchanged in a subgroup of individuals without METS and/or diabetes. Conclusions Increasing levels of METS-IR were significantly associated with a greater risk of incident CHD, diabetes, and hypertension; therefore, this index can be a useful tool for capturing the risk of these clinical outcomes.

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A Novel Metabolic Score for Insulin Resistance and Symptomatic Intracranial Hemorrhage in Ischemic Stroke Patients After Endovascular Thrombectomy

Cited by 3 publications

References 37 publications

Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study

Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study

An innovative metabolic index for insulin resistance correlates with early neurological deterioration following intravenous thrombolysis in minor acute ischemic stroke patients

Association between metabolic score for insulin resistance and clinical outcomes: insights from the Tehran lipid and glucose study

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