A Novel Melatonin Metabolite, Cyclic 3-Hydroxymelatonin: A Biomarker ofin VivoHydroxyl Radical Generation

Melatonin as potential candidate to prevent the toxicity induced by chemical warfare agents

“…HOCl has a high capacity to inactivate enzymes involved in antioxidant defense system, inducing a disruption of redox homeostasis. The ability of one melatonin molecule to apparently interact with more than one HOCl molecule is consistent with observations made by Tan et al (1998), who found that melatonin also neutralizes more than one hydroxyl radical. An interesting study, using the Chinese hamster B14 cell line, provided further evidence that HOCl-induced toxicity was counteracted by melatonin.…”

Synergistic effects of melatonin and deprenyl against MPTP-induced mitochondrial damage and DA depletion

“…Thus, it is necessary that use of antioxidants that penetrates the bloodbrain barrier such as melatonin [24]. Melatonin displays important antioxidant properties based on its free radical scavenger ability [46,48,52,53] and, in contrast to conventional antioxidants, rapidly crosses the blood-brain barrier after systemic administration and reaches every neuronal compartment [41]. Melatonin also regulates the expression and activity of the redox enzymes [9,16].…”

Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice

“…aMT beneficial effects depends on its direct free radical scavenging activity and its indirect antioxidant actions (Reiter et al, 2000;Tan et al, 2000a;Tan et al, 2007). The indoleamine is highly efficient in detoxifying the devastatingly toxic hydroxyl radical (HO•) Tan et al, 1998), and H 2 O 2, peroxynitrite anion (ONOO -) and, in a lesser extent, nitric oxide (NO•) (Reiter et al, 2000Turjanski et al, 2001). However, aMT mainly reduces NO• through the inhibition of its synthesizing enzyme, nitric oxide synthase NOS (Escames et al, 2003).…”