A Novel Mechanism Underlying Activity-Dependent Pruning in Postnatal Prefrontal Cortex

Auger, Meagan L.

doi:10.1523/jneurosci.2394-19.2020

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Synaptic Plasticity1

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2021

2023

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Cited by 2 publications

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“…In the neocortex, SEMA3B and SEMA3F were shown to have a role in pruning synapses selectively at apical dendrites, depending on the expression of adhesion molecules [ 66 , 67 , 68 , 69 ]. Close Homologous L1 (CHL1) and NrCAM associate to NRP2 to form a surface heterocomplex, stabilizing binding to PLXNA4 or PLXNA3, respectively, and enabling affinity to different extracellular SEMAs.…”

Section: Synaptic Plasticitymentioning

confidence: 99%

Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins

Limoni

2021

IJMS

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The establishment of neuronal circuits requires neurons to develop and maintain appropriate connections with cellular partners in and out the central nervous system. These phenomena include elaboration of dendritic arborization and formation of synaptic contacts, initially made in excess. Subsequently, refinement occurs, and pruning takes places both at axonal and synaptic level, defining a homeostatic balance maintained throughout the lifespan. All these events require genetic regulations which happens cell-autonomously and are strongly influenced by environmental factors. This review aims to discuss the involvement of guidance cues from the Semaphorin family.

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