A novel mechanism for cognitive enhancement in aged dogs with the use of a calcium-buffering protein

Milgram, Norton W.; Landsberg, Gary; Merrick, D.; Underwood, Mark

doi:10.1016/j.jveb.2015.02.003

Cited by 14 publications

(11 citation statements)

References 28 publications

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“…As CaMKII regulated cAMP-response element binding protein (CREB) is involved in maintaining appropriate cognitive formation, disruption of calcium signaling by diabetic hyperglycemia can thus result in cognitive impairment [38] (Figure 1). Conversely, modulation of calcium-binding protein apoaequorin could have positive effects in treating cognitive dysfunction [39,40]. Additionally, the transport of calcium across the inner mitochondrial membrane could also play a key role in neuronal physiology and pathology [41].…”

Section: Diabetes Enhanced Ca 2+ Dysregulation Is a Vital Pathogenic mentioning

confidence: 99%

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

Xing¹,

Tang²,

Lei³

et al. 2020

Aging and disease

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The goal of this review was to summarize current biochemical mechanisms of and risk factors for diabetic brain injury. We mainly summarized mechanisms published in the past three years and focused on diabetes induced cognitive impairment, diabetes-linked Alzheimer's disease, and diabetic stroke. We think there is a need to conduct further studies with increased sample sizes and prolonged period of follow-ups to clarify the effect of DM on brain dysfunction. Additionally, we also think that enhancing experimental reproducibility using animal models in conjunction with application of advanced devices should be considered when new experiments are designed. It is expected that further investigation of the underlying mechanisms of diabetic cognitive impairment will provide novel insights into therapeutic approaches for ameliorating diabetes-associated injury in the brain.

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Section: Diabetes Enhanced Ca 2+ Dysregulation Is a Vital Pathogenic mentioning

confidence: 99%

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

Xing¹,

Tang²,

Lei³

et al. 2020

Aging and disease

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“…Disturbance of intracellular calcium is associated with aging and may be linked to CDS in dogs [106]. Two 32-day studies were conducted to investigate the effects of apoaequorin, a calcium buffering protein, on cognitive function in aged dogs.…”

Section: Nutritional Interventions Targeting Oxidative Damage-related Brain Agingmentioning

confidence: 99%

“…The dogs treated with 10-mg apoaequorin showed significantly better performance compared with the dogs treated with selegiline on both tasks. The authors concluded that "these results suggest the calcium-binding protein apoaequorin may have beneficial effects in treating cognitive dysfunction in aged beagle dogs and that apoaequorin is at least as beneficial as selegiline" [106].…”

Section: Nutritional Interventions Targeting Oxidative Damage-related Brain Agingmentioning

confidence: 99%

Nutrients, Cognitive Function, and Brain Aging: What We Have Learned from Dogs

Pan¹

2021

Medical Sciences

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Due to a difference in genetics, environmental factors, and nutrition, just like in people, dogs age at different rates. Brain aging in people and dogs share similar morphological changes including irreversible cortical atrophy, cerebral amyloid angiopathy, and ventricular enlargement. Due to severe and irreversible brain atrophy, some aging dogs develop cognitive dysfunction syndrome (CDS), which is equivalent to dementia or Alzheimer’s disease (AD) in people. The risk factors and causes of CDS in dogs have not been fully investigated, but age, gender, oxidative stress, and deficiency of sex hormones appears to be associated with increased risk of accelerated brain aging and CDS in dogs. Both AD and CDS are incurable diseases at this moment, therefore more efforts should be focused on preventing or reducing brain atrophy and minimizing the risk of AD in people and CDS in dogs. Since brain atrophy leads to irreversible cognitive decline and dementia, an optimal nutritional solution should be able to not only enhance cognitive function during aging but also reduce irreversible brain atrophy. Up to now, only one nutritional intervention has demonstrated both cognition-enhancing benefits and atrophy-reducing benefits.

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“…Apoaequorin is a calcium-buffering protein with neuroprotective effects positively influencing learning and attention abilities (May and Laflamme 2019). A recent study demonstrated that 10 mg apoaequorin showed superior performance on cognitive tasks compared with dogs receiving 1 mg/kg selegiline (Milgram et al 2015) S-Adenosyl-l-Methionine (SAMe) is a product of methionine and is essential for liver functions. Exogenous SAMe causes a rise in serotonin turnover and dopamine and norepinephrine levels by raising endogenous glutathione production (May and Laflamme 2019).…”

Section: Dietary and Nutraceutical Treatmentmentioning

confidence: 99%

Köpeklerin Yaşlanmaya Bağlı Bilişsel Bozukluğu

Raouf

Aağan

Uzun

et al. 2021

Van Veterinary Journal

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Canine cognitive disorder (CDS) is a neurodegenerative, progressive, and irreversible disorder of senior dogs, generally over eight years old. CDS is characterized by a decrease in cognitive functions. Clinically significant changes in dog's behavior and daily routines including disorientation, decrease in social interactions, changes in sleep-wake cycles, loss of household habits, poor communication, increased anxiety, and changes in activity levels with the potential to create significant problems and discomfort in the lifestyle of the owners, deteriorating pet-owner attachment and generally be frustrating for the owner. The definite diagnosis depends on brain biopsies, and there is no confirmed clinical diagnosis method developed, meeting the whole criteria of CDS. The owner assessment using several scales available is the primary tool to rely on, which has a high potential to be subjective. Although it still has many dark sides, CDS is a disease with convenient diagnostic and therapeutic strategies available. Veterinarians need to consider this disease in geriatric patients and cooperate by increasing owner awareness, stopping or at least slowing down the disease in elderly dogs, and making the geriatric period more comfortable for both the dog and the owner. This review aims to introduce current information in the diagnosis and treatment of CDS.

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A novel mechanism for cognitive enhancement in aged dogs with the use of a calcium-buffering protein

Cited by 14 publications

References 28 publications

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus

Nutrients, Cognitive Function, and Brain Aging: What We Have Learned from Dogs

Köpeklerin Yaşlanmaya Bağlı Bilişsel Bozukluğu

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