A Novel Mathematical Model for Correcting the Physiologic Variance of Two-Dimensional Echocardiographic Measurements in Healthy Chinese Adults

Yao, Guihua; Chen, Xiangyun; Zhang, Qing; Zeng, Xueying; Li, Xuanlong; Zhang, Sen; Jiang, Peiqing; Feng, Xuan; Sun, Fengzhong; Xu, Jinfeng; Zhang, Meng; Zhang, Cheng; Yin, Long; Zhang, Mei; Zhang, Yun

doi:10.1016/j.echo.2019.02.010

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…Despite its slight advantage over BSA for the correction of cardiac dimensions, height did not achieve satisfactory correction results for aortic dimensions in the present study. In our lately published study, 33 we confirmed that cardiovascular dimensions, including the aorta were nonlinearly or curvilinearly correlated with age and body size. We developed a novel optimized multivariate allometric model to successfully correct the physiological discrepancies of 2DE parameters induced by age, gender, and body size.…”

Section: Discussionsupporting

confidence: 75%

Comparisons of Two-dimensional Echocardiographic Aortic Dimensions between Chinese, Japanese, and Europeans

Lin

Lü

et al. 2023

Journal of Thoracic Imaging

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Purpose: We aimed to investigate the impacts of age, gender, and race on aortic dimensions in healthy adults. Methods: We analyzed data from 3 large population-based sample studies, including Chinese Echocardiographic Measurements in Normal Chinese Adults, Japanese the Normal Values for Echocardiographic Measurements Project, and European Normal Reference Ranges for Echocardiography, to compare the two-dimensional echocardiography-derived aortic diameters at different levels and to explore the effects of age, gender, and race on aortic measurements. We also compared the values corrected by body surface area (BSA) or height. Results: The results are as follows: (1) Aortic diameters showed positive correlations with age (r=0.12-0.42, P<0.05), and there were significant inter-age group differences before and after indexing to BSA (P<0.05); (2) Men had greater measurements of aortic diameters than women, with the differences being the same when indexed to height. However, indexing to BSA reversed the differences; (3) The aortic diameters at annulus (Ao-a) and sinus (Ao-s) levels were very close with minor differences between the Chinese and Japanese regardless of whether BSA was used for correction; and (4) The aortic measurements at Ao-s and proximal ascending aorta (Ao-asc) levels in the Chinese were significantly lower than in the Europeans for both genders, with the differences remaining the same even after indexing to BSA or height (P<0.05). Conclusion: Aortic dimensions vary with age and gender, and there are significant differences between races or ethnicities even when stratified by gender and age. The indexation by BSA or height cannot eliminate these differences. Therefore, age-specific, gender-specific, race-specific, and nationality-specific reference values may be more appropriate at present for clinical practice to avoid misdiagnosis and misclassification of aortic dilation.

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Section: Discussionsupporting

confidence: 75%

Comparisons of Two-dimensional Echocardiographic Aortic Dimensions between Chinese, Japanese, and Europeans

Lin

Lü

et al. 2023

Journal of Thoracic Imaging

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“…At present, indexing echocardiographic measurements of cardiac chambers by BSA is recommended by the ASE/EACVI guidelines 12 . However, our previous study revealed that the total success rate of correcting for 34 2D echocardiographic parameters, including isometric weight, height, body mass index, and BSA was only 11% 24 . Similarly, the WASE 3D‐LV study failed to correct for the impact of race on 3D‐LV volume using isometric BSA 23 .…”

Section: Discussionmentioning

confidence: 94%

“…used several methods including BSA, BSA 1.5 , BSA 1.8 , height, height 2.3 , height 2.9 , and estimated lean body mass, to index of 3D‐LV end‐diastolic volume; however, these methods failed to correct the difference between races and nationalities 25 . Recently, our group developed an optimized multivariate allometric model using different scaling equations for different echocardiographic parameters, and achieved a high success rate of correction (100%) for 34 parameters measured by 2D echocardiography 24 . However, whether this model can be used to correct physiological variance in 3D‐RV measurements awaits further investigation.…”

Section: Discussionmentioning

confidence: 99%

“… 12 However, our previous study revealed that the total success rate of correcting for 34 2D echocardiographic parameters, including isometric weight, height, body mass index, and BSA was only 11%. 24 Similarly, the WASE 3D‐LV study failed to correct for the impact of race on 3D‐LV volume using isometric BSA. 23 In the present study, there was still a difference in the RVEDVi and RVESVi between men and women, even after indexing by isometric BSA, indicating that indexing method recommended by current guidelines should be abandoned.…”

Section: Discussionmentioning

confidence: 99%

“… 25 Recently, our group developed an optimized multivariate allometric model using different scaling equations for different echocardiographic parameters, and achieved a high success rate of correction (100%) for 34 parameters measured by 2D echocardiography. 24 However, whether this model can be used to correct physiological variance in 3D‐RV measurements awaits further investigation.…”

Section: Discussionmentioning

confidence: 99%

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Right ventricular volume and function by three‐dimensional echocardiography: results of the echocardiographic measurements in normal Chinese adults (EMINCA) II

Zhang,

Wang,

Yao

et al. 2024

MedComm

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Three‐dimensional (3D) echocardiography is an emerging technique for assessing right ventricular (RV) volume and function, but 3D‐RV normal values from a large Chinese population are still lacking. The aim of the present study was to establish normal values of 3D‐RV volume and function in healthy Chinese volunteers. A total of 1117 Han Chinese volunteers from 28 laboratories in 20 provinces of China were enrolled, and 3D‐RV images of 747 volunteers with optimal image quality were ultimately analyzed by a core laboratory. Both vendor‐dependent and vendor‐independent software platforms were used to analyze the 3D‐RV images. We found that men had larger RV volumes than women did in the whole population, even after indexing to body surface area, and older individuals had smaller RV volumes. The normal RV volume was significantly smaller than that recommended by the American Society of Echocardiography/European Association of Cardiovascular Imaging guidelines in both sexes. There were significant differences in 3D‐RV measurements between the two vendor ultrasound systems and the different software platforms. The echocardiographic measurements in normal Chinese adults II study revealed normal 3D‐RV volume and function in a large Chinese population, and there were significant differences between the sexes, ages, races, and vendor groups. Thus, normal 3D‐RV values should be stratified by sex, age, race, and vendor.

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Inferior Right Ventricular Wall Thickness by Echocardiogram: A Novel Method of Assessing Hypertrophy in Neonates and Infants

et al. 2020

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A Novel Mathematical Model for Correcting the Physiologic Variance of Two-Dimensional Echocardiographic Measurements in Healthy Chinese Adults

Cited by 9 publications

References 36 publications

Comparisons of Two-dimensional Echocardiographic Aortic Dimensions between Chinese, Japanese, and Europeans

Comparisons of Two-dimensional Echocardiographic Aortic Dimensions between Chinese, Japanese, and Europeans

Right ventricular volume and function by three‐dimensional echocardiography: results of the echocardiographic measurements in normal Chinese adults (EMINCA) II

Inferior Right Ventricular Wall Thickness by Echocardiogram: A Novel Method of Assessing Hypertrophy in Neonates and Infants

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