A Novel Magnetic Stimulator Increases Experimental Pain Tolerance in Healthy Volunteers - A Double-Blind Sham-Controlled Crossover Study

Kortekaas, Rudie; Nierop, Lotte E. van; Baas, Veroni G.; Konopka, Karl-Heinz; Harbers, mr. E.H.M.; Hoeven, Johannes H. van der; Wijhe, Marten van; Alemán, André; Maurits, Natasha M.

doi:10.1371/journal.pone.0061926

Cited by 9 publications

(5 citation statements)

References 29 publications

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“…Many experimental pain paradigms also offer the advantage of avoiding tissue damage and inflammation, hence allowing researchers to determine if a given treatment directly influences pain perception. To our knowledge, very few studies looked at the effect of PEMF on experimental pain (Fernandez et al 2007;Kortekaas et al 2013;Shupak et al 2004). In one study, conducted by Shupak et al (2004), the authors evaluated the effect of PEMF on thermal non-nociceptive and nociceptive thresholds in a group of healthy volunteers.…”

Section: Effect Of Pemf On Experimental Painmentioning

confidence: 99%

“…Many experimental pain paradigms allow for the assessment of pain and nociceptive responses in the absence of tissue injury or inflammation, thus offering a unique opportunity to evaluate the direct analgesic effect of a given intervention. To date, very few studies evaluated the analgesic effects of PEMF using experimental pain (Fernandez et al 2007;Kortekaas et al 2013;Shupak et al 2004). …”

Section: Introductionmentioning

confidence: 99%

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Effect of pulsed electromagnetic field therapy on experimental pain: A double-blind, randomized study in healthy young adults

Beaulieu

Beland

Pinard

et al. 2016

Electromagnetic Biology and Medicine

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Past studies have suggested that pulsed electromagnetic field (PEMF) therapy can decrease pain. To date, however, it remains difficult to determine if the analgesic effect observed in patients are attributable to a direct effect of PEMF on pain or to an indirect effect of PEMF on inflammation and healing. In the present study, we used an experimental pain paradigm to evaluate the direct effect of PEMF on pain intensity, pain unpleasantness and temporal summation of pain. Twenty-four healthy subjects (mean age 22 ± 2 years; 9 males) participated in the experiment. Both real and sham PEMF were administered to every participant using a randomized, double-blind, cross-over design.For each visit, PEMF was applied for 10 minutes on the right forearm using a portable device. Experimental pain was evoked before (baseline) and after PEMF with a 9 cm 2 Pelletier type thermode, applied on the right forearm (120 sec stimulation; temperature individually adjusted to produce moderate baseline pain). Pain intensity and unpleasantness were evaluated using a 0-100 numerical pain rating scale.

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Section: Effect Of Pemf On Experimental Painmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of pulsed electromagnetic field therapy on experimental pain: A double-blind, randomized study in healthy young adults

Beaulieu

Beland

Pinard

et al. 2016

Electromagnetic Biology and Medicine

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“…Magnetotherapy promotes inflammation reduction, accelerating the tissue repair process and favors the organization of collagen fibers, according to tension lines, without formation of fibrosis. Studies show that magnetic field therapy has been used in several areas of tissue repair, such as skin, muscle and bone injuries (16)(17)(18)(19) . Thus, this feature decreases the regeneration time of the lesions and the patients returns to their activities earlier.…”

Section: Discussionmentioning

confidence: 99%

Effect of the magnetotherapy in the regeneration after tenotomy in animals

Grimaldo¹,

Silva²,

Bezerra³

et al. 2019

Manual Therapy, Posturology &Amp; Rehabilitation Journal

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Background:The Achilles tendon is the largest and most resistant tendon in the human body, being one of the most common areas of overload injury among athletes. The rupture occurs more frequently in football athletes, running and jumping, because these activities cause a great stress on the tendon during eccentric muscle contraction of the sural triceps. Among the different physiotherapy resources used to repair tendon injuries, there is magnetotherapy, which is a feature that uses a pulsatile electromagnetic field, a suggested inducer of the acceleration of regeneration. Objective: To investigate the effects of magnetotherapy on the organization of collagen and elastic fibers and inflammatory process induced in different days and phases of the healing process of Achilles tendon injury in rats. Method: This study is a randomized controlled trial. Thirty female Wistar rats were randomly divided into 5 groups (each with n = 6), submitted to tenotomy by transverse shear in the middle third of the right Achilles tendon, except for group 1, which was control group without injury, sacrificed on day 14. Group 2, control with injury, sacrificed on day 7; group 3 was treated and received 5 pulsed electromagnetic field (PEMF) applications from 24h post injury and sacrificed on day 7; group 4, control with injury and sacrificed on day 14; and group 5 received 12 PEMF applications from 24h post injury and sacrificed on day 14. The parameters used were 20 mT, 50Hz and 30 minutes of application in each session, using the Magnetherp  330 digital device (Meditea  ). At the end of treatment, a histological study was performed to evaluate the amount of collagen and elastic cells and fibers and to compare the degree of organization of collagen fibers. Results: G -3, compared to its control G -2 showed lower acute inflammatory response; G -5 did not show acute and chronic inflammation and possessed an accelerated process of repair without fibrosis, unlike its control. Conclusion:The magnetotherapy decreased the signs of inflammation in the acute phase, accelerated the repair process with the onset of fibrosis in 7 days; and at 14 days the tendon tissue was healed, with organizing fibrosis, without acute or chronic inflammation.

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“…However, this evidence stems from a rather small-scale study. In people with mood disorder [ 8 ] and pain [ 9 ] weak magnetic fields like Pulsed Electromagnetic Fields (PEMFs) have been deployed with varying levels of success in treatments. The combination of light therapy and electromagnetic field therapy in the treatment unit Xentix [ 10 ] might be seen as a supplementary treatment.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a randomized controlled trial on the effect on return to work with coaching combined with light therapy and pulsed electromagnetic field therapy for workers with work-related chronic stress

et al. 2017

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BackgroundChronic work-related stress is quite prevalent in the working population and is in some cases accompanied by long-term sick leave. These stress complaints highly impact employees and are costly due to lost productivity and medical expenses. A new treatment platform with light therapy plus Pulsed Electro Magnetic Fields (PEMF) in combination with coaching was used to assess whether more positive effects on return to work, stress, work-related fatigue, and quality of life could be induced compared to coaching alone.MethodsA placebo-controlled trial was executed after inclusion of 96 workers, aged 18–65 with work-related chronic stress complaints and who were on sick leave (either part-time or full-time). Participants were divided into three arms at random. Group 1 (n = 28) received the treatment and coaching (Intervention group), group 2 (n = 28) received the treatment with the device turned off and coaching (Placebo group) and group 3 (n = 28) received coaching only (Control group). The data were collected at baseline, and after 6, 12 and 24 weeks. The primary outcome was % return to work, and secondary outcomes were work-related fatigue (emotional exhaustion and need for recovery after work), stress (distress and hair cortisol), and quality of life (SF-36 dimensions: vitality, emotional role limitation, and social functioning).ResultsEighty-four workers completed all measurements, 28 in each group. All groups improved significantly over time in the level of return to work, as well as on all secondary outcomes. No statistical differences between the three groups were found either on the primary outcome or on any of the secondary outcomes.ConclusionsLight therapy with Pulsed Electro Magnetic Fields PEMF therapy has no additional effect on return to work, stress, fatigue, and quality of live compared to coaching alone.Trial registration NTR4794, registration date: 18-sep-2014

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A Novel Magnetic Stimulator Increases Experimental Pain Tolerance in Healthy Volunteers - A Double-Blind Sham-Controlled Crossover Study

Cited by 9 publications

References 29 publications

Effect of pulsed electromagnetic field therapy on experimental pain: A double-blind, randomized study in healthy young adults

Effect of pulsed electromagnetic field therapy on experimental pain: A double-blind, randomized study in healthy young adults

Effect of the magnetotherapy in the regeneration after tenotomy in animals

Evaluation of a randomized controlled trial on the effect on return to work with coaching combined with light therapy and pulsed electromagnetic field therapy for workers with work-related chronic stress

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