A novel magnetic method for examination of bowel motility

Andrä, W.; Danan, H.; Eitner, K; Hocke, Michael; Kramer, Hans-Helmar; Parusel, Henry; Saupe, Pieter; Werner, Christoph; Bellemann, Matthias E.

doi:10.1118/1.2012788

Cited by 14 publications

(6 citation statements)

References 7 publications

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“…Like SQUID systems, AMR sensors have the same principle for localization of solid dosage forms and are also based on the detection of magnetic dipole (10,91). As these sensors are less sensitive, they can be operated in unshielded rooms; however, a higher amount of magnetic material for labelling the dosage forms is needed.…”

Section: Amr Sensorsmentioning

confidence: 98%

Biomagnetic Methods: Technologies Applied to Pharmaceutical Research

et al. 2010

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Biomagnetic methods have been designed for a wide range of applications. Recently, such methods have been proposed as alternatives to scintigraphy for evaluating of a number of pharmaceutical processes in vitro as well as under the influence of gastrointestinal physiological parameters. In this review, physical characterization as well as the most recent applications of Superconducting Quantum Interference Device (SQUID), Anisotropic Magnetoresistive (AMR) and AC Biosusceptometry (ACB) in the pharmaceutical research will be explored. Moreover, their current status and how these technologies can be employed to improve the knowledge about the impact of gastrointestinal physiology on drug delivery in association with pharmacokinetic outcomes, termed pharmacomagnetography, will be presented.

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Section: Amr Sensorsmentioning

confidence: 98%

Biomagnetic Methods: Technologies Applied to Pharmaceutical Research

et al. 2010

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“…Generally, they relate to the thoracic or abdominal organs [15], and have used various motion observation techniques: an ultrasound scanner [11], digital fluoroscopy [33], a gamma scintillation camera [43], or a magnetic method [1]. The purposes of these observations are multiple: to improve image acquisition [11,43], to investigate field margins [33], or to examine effects on organs at risk [1]. Not all imaging modalities are appropriate to all tumour sites.…”

Section: Organ Motions In Radiotherapymentioning

confidence: 99%

A Morphing Technique Applied to Lung Motions in Radiotherapy: Preliminary Results

Laurent¹,

Henriet²,

Gschwind³

et al. 2010

Acta Polytech

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Organ motion leads to dosimetric uncertainties during a patient’s treatment. Much work has been done to quantify the dosimetric effects of lung movement during radiation treatment. There is a particular need for a good description and prediction of organ motion. To describe lung motion more precisely, we have examined the possibility of using a computer technique: a morphing algorithm. Morphing is an iterative method which consists of blending one image into another image. To evaluate the use of morphing, Four Dimensions Computed Tomography (4DCT) acquisition of a patient was performed. The lungs were automatically segmented for different phases, and morphing was performed using the end-inspiration and the end-expiration phase scans only. Intermediate morphing files were compared with 4DCT intermediate images. The results showed good agreement between morphing images and 4DCT images: fewer than 2 % of the 512 by 256 voxels were wrongly classified as belonging/not belonging to a lung section. This paper presents preliminary results, and our morphing algorithm needs improvement. We can infer that morphing offers considerable advantages in terms of radiation protection of the patient during the diagnosis phase, handling of artifacts, definition of organ contours and description of organ motion.

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“…A new possibility for the in vivo observation of the dissolution behavior of pharmaceutical tablets and capsules is the technique of magnetic marker monitoring [6], [7]. The magnetic field outside of the patient is measured after ingesting a magnetically marked capsule.…”

Section: Introductionmentioning

confidence: 99%

Dissolution of magnetically marked tablets: Investigations in a physical phantom

Biller

Domey

Fiedler

et al. 2012

2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Pharmacological research is strongly driven by maximizing the bioavailability of new pharmaceuticals. For orally applied drugs the bioavailability highly depends on the process of dissolution in the gastrointestinal tract and is affected by numerous physiological and environmental factors. Available techniques for in vivo monitoring of the dissolution process are very limited and not applicable for large studies. The technique of magnetic marker monitoring provides new prospects for these investigations. However, it is currently limited due to low fields common magnetic markers produce. Hence, only highly sensitive sensors are applicable. In this paper, we performed dissolution tests of novel markers in a physical phantom with magnetoresistive sensors in an unshielded environment. The markers were continuously localized and the movement through the phantom was tracked. By analyzing the changing magnetic moment of the markers we were able to monitor the progress of dissolution in the phantom. We conclude that our proposed phantom and tracking technique is an important step towards new systems for in vivo monitoring of pharmaceutical dissolution processes.

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A novel magnetic method for examination of bowel motility

Cited by 14 publications

References 7 publications

Biomagnetic Methods: Technologies Applied to Pharmaceutical Research

Biomagnetic Methods: Technologies Applied to Pharmaceutical Research

A Morphing Technique Applied to Lung Motions in Radiotherapy: Preliminary Results

Dissolution of magnetically marked tablets: Investigations in a physical phantom

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