A Novel Magnetic Carbon Nanotubes Functionalized with Pyridine Groups: Synthesis, Characterization and Their Application as an Efficient Carrier for Plasmid DNA and Aptamer

Kaboudin, Babak; Saghatchi, Fatemeh; Kazemi, Foad; Akbari‐Birgani, Shiva

doi:10.1002/slct.201800708

Cited by 17 publications

(11 citation statements)

References 67 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MWCNT functionalised with pyridine and magnetic particles transported nucleic acids bound by π-π interactions through the cell membrane and released them in the cytoplasm. A magnetic field was then applied to remove the nanocarriers from the cell, thus limiting their cytotoxicity [ 54 ]. Magnetically guided nanocarriers were also considered by Xu et al through the one-step preparation of magnetic MWCNT using a paramagnetic surfactant coating.…”

Section: Carbon Nanotubes (Cnt) For Biomedical Applicationsmentioning

confidence: 99%

Overview of Carbon Nanotubes for Biomedical Applications

2019

View full text Add to dashboard Cite

The unique combination of mechanical, optical and electrical properties offered by carbon nanotubes has fostered research for their use in many kinds of applications, including the biomedical field. However, due to persisting outstanding questions regarding their potential toxicity when considered as free particles, the research is now focusing on their immobilization on substrates for interface tuning or as biosensors, as load in nanocomposite materials where they improve both mechanical and electrical properties or even for direct use as scaffolds for tissue engineering. After a brief introduction to carbon nanotubes in general and their proposed applications in the biomedical field, this review will focus on nanocomposite materials with hydrogel-based matrices and especially their potential future use for diagnostics, tissue engineering or targeted drug delivery. The toxicity issue will also be briefly described in order to justify the safe(r)-by-design approach offered by carbon nanotubes-based hydrogels.

show abstract

Section: Carbon Nanotubes (Cnt) For Biomedical Applicationsmentioning

confidence: 99%

Overview of Carbon Nanotubes for Biomedical Applications

2019

View full text Add to dashboard Cite

show abstract

“…Kaboudin et al have revealed that nucleic acid can be transfected by a method other than endocytosis. MWCNTs functionalized with pyridine and magnetic particles transported nucleic acids bound by interactions over the cell membrane and into the cytoplasm [69]. The nanocarriers were subsequently removed from the cell using a magnetic field, thereby minimizing their cytotoxicity [70].…”

Section: Uses Of Cnts In Biomedicinementioning

confidence: 99%

Recent Insights and Multifactorial Applications of Carbon Nanotubes

et al. 2021

View full text Add to dashboard Cite

Nanotechnology has undergone significant development in recent years, particularly in the fabrication of sensors with a wide range of applications. The backbone of nanotechnology is nanostructures, which are determined on a nanoscale. Nanoparticles are abundant throughout the universe and are thought to be essential building components in the process of planet creation. Nanotechnology is generally concerned with structures that are between 1 and 100 nm in at least one dimension and involves the production of materials or electronics that are that small. Carbon nanotubes (CNTs) are carbon-based nanomaterials that have the structure of tubes. Carbon nanotubes are often referred to as the kings of nanomaterials. The diameter of carbon is determined in nanometers. They are formed from graphite sheets and are available in a variety of colors. Carbon nanotubes have a number of characteristics, including high flexibility, good thermal conductivity, low density, and chemical stability. Carbon nanotubes have played an important part in nanotechnology, semiconductors, optical and other branches of materials engineering owing to their remarkable features. Several of the applications addressed in this review have already been developed and used to benefit people worldwide. CNTs have been discussed in several domains, including industry, construction, adsorption, sensors, silicon chips, water purifiers, and biomedical uses, to show many treatments such as injecting CNTs into kidney cancers in rats, drug delivery, and directing a near-infrared laser at the cancers. With the orderly development of research in this field, additional therapeutic modalities will be identified, mainly for dispersion and densification techniques and targeted drug delivery systems for managing and curing posterior cortical atrophy. This review discusses the characteristics of carbon nanotubes as well as therapeutic applications such as medical diagnostics and drug delivery.

show abstract

“…Moreover, a non-viral cargo meets the criteria to qualify as a strong vector for gene therapy such as plentiful payload sum, intracellular internalization, targeted delivery and low toxicity. Scientists have utilized different types of payloads, for example, DNA, RNA, oligonucleotides (ODN), and aptamers for gene therapy along with wide tool-box of f-CNTs ( Figure 2), for the efficient delivery of biomolecules [1][2][3] into plants [44] and mammalian [42] cells. The most widely used protocol is provided by Pantarotto et al [45] where they used ammonium functionalized nanotubes (MWCNTs and SWCNTs) to form a complex with plasmid DNA (pDNA) by means of ionic bonding, which viably conveyed pDNA intracellularly.…”

Section: Conjugation Of Functionalized Carbon Nanotubes With Genes Anmentioning

confidence: 99%

Derivatized Carbon Nanotubes for Gene Therapy in Mammalian and Plant Cells

et al. 2020

View full text Add to dashboard Cite

The concept of gene vectors for therapeutic applications has been known for several years, but it is far from revealing its actual potential. With the advent of hollow cylindrical carbon nanomaterials such as carbon nanotubes (CNTs), researchers have invented several new tools to deliver genes at the required site of action in mammalian and plant cells. The ease of diversified functionalization has allowed CNTs to be by far the most adaptable non‐viral vector for gene therapy. This Minireview addresses the dexterity with which CNTs undergo surface modifications and their applications as a potent vector in gene therapy of humans and plants. Specifically, we will discuss the new tools that scientific communities have invented to achieve gene therapy using plasmid DNA, RNA silencing, suicide gene therapy, and plant genetic engineering. Additionally, we will shed some light on the mechanism of gene transportation using carbon nanotubes in cancer cells and plants.

show abstract

A Novel Magnetic Carbon Nanotubes Functionalized with Pyridine Groups: Synthesis, Characterization and Their Application as an Efficient Carrier for Plasmid DNA and Aptamer

Cited by 17 publications

References 67 publications

Overview of Carbon Nanotubes for Biomedical Applications

Overview of Carbon Nanotubes for Biomedical Applications

Recent Insights and Multifactorial Applications of Carbon Nanotubes

Derivatized Carbon Nanotubes for Gene Therapy in Mammalian and Plant Cells

Contact Info

Product

Resources

About