A novel locus for canine osteosarcoma (OSA1) maps to CFA34, the canine orthologue of human 3q26

Phillips, Jeffrey; Lembcke, Luis M.; Chamberlin, Tamara

doi:10.1016/j.ygeno.2010.07.002

Cited by 33 publications

(32 citation statements)

References 26 publications

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“…Thus, dogs are commonly affected by many cancer types that strongly resemble human cancers and segregate in at-risk dog breeds. As examples, brachycephalic dogs have higher frequencies of glioma than any other breed (Thomas et al, 2009) and large dog breeds are prone to osteosarcoma (Phillips et al, 2010), Labrador retrievers commonly develop diffuse large B-cell lymphoma (DLCBL), whereas German shepherds are more prone to T cell lymphoma (Pastor et al, 2009). Bernese mountain dogs are severely affected by histiocytic sarcoma, with 20% affected at a mean age of 6 yrs (Hedan et al, 2011;Shearin et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Naturally occurring melanomas in dogs as models for non‐UV pathways of human melanomas

Gillard

Cadieu

Brito

et al. 2013

Pigment Cell Melanoma Res

139

225

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Spontaneously occurring melanomas are frequent in dogs. They appear at the same localizations as in humans, i.e. skin, mucosal sites, nail matrix and eyes. They display variable behaviors: tumors at oral localizations are more frequent and aggressive than at other anatomical sites. Interestingly, dog melanomas are associated with strong breed predispositions and overrepresentation of black-coated dogs. Epidemiological analysis of 2350 affected dogs showed that poodles are at high risk of developing oral melanoma, while schnauzers or Beauce shepherds mostly developped cutaneous melanoma. Clinical and histopathological analyses were performed on a cohort of 153 cases with a 4-yr follow-up. Histopathological characterization showed that most canine tumors are intradermal and homologous to human rare morphological melanomas types - 'nevocytoid type' and 'animal type'-. Tumor cDNA sequencing data, obtained from 95 dogs for six genes, relevant to human melanoma classification, detected somatic mutations in oral melanoma, in NRAS and PTEN genes, at human hotspot sites, but not in BRAF. Altogether, these findings support the relevance of the dog model for comparative oncology of melanomas, especially for the elucidation of non-UV induced pathways.

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Section: Introductionmentioning

confidence: 99%

Naturally occurring melanomas in dogs as models for non‐UV pathways of human melanomas

Gillard

Cadieu

Brito

et al. 2013

Pigment Cell Melanoma Res

139

225

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“…2-17.1). 70 This region contains two tumour suppressor genes -PPM1L and MECOM, which are crucial for cell proliferation and maintenance haematopoietic stem cells. Interestingly, Arg → Gln the orthologous region on human chromosome 3 (HSA3q26) is known for loss of heterozygosity in OSA patients.…”

Section: Domestic Mammalsmentioning

confidence: 99%

Germline gene polymorphisms predisposing domestic mammals to carcinogenesis

Flisikowski

Flisikowska

Sikorska

et al. 2015

Vet Comparative Oncology

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Cancer is a complex disease caused in part by predisposing germline gene polymorphisms. Knowledge of carcinogenesis in companion mammals (dog and cat) and some livestock species (pig and horse) is quite advanced. The prevalence of certain cancers varies by breed in these species, suggesting the presence of predisposing genetic variants in susceptible breeds. This review summarizes the present understanding of germline gene polymorphisms, including BRCA1, BRCA2, MC1R, KIT, NRAS and RAD51, associated with predisposition to melanoma, mammary cancer, osteosarcoma and histiocytic sarcoma in dogs, cats, pigs and horses. The predisposing variants in these species are discussed in the context of human germline gene polymorphisms associated with the same types of cancer.

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“…Osteosarcoma risk was concluded to be governed largely by a single major genetic variant with dominant expression that was located on an autosome and increased the risk of disease 15-fold, from a baseline risk of 5% in a Deerhound without the variant to a risk of 75% in a Deerhound that had the variant. A whole genome linkage approach was subsequently used to analyze DNA samples from 60 of these dogs and map the variant to CFA34 [6]. …”

Section: Introductionmentioning

confidence: 99%

Osteosarcoma inheritance in two families of Scottish deerhounds

Dillberger

McAtee

2017

Canine Genet Epidemiol

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BackgroundOsteosarcoma is the most common neoplastic disease in Scottish Deerhounds. For Deerhounds, a 2007 population-based study concluded that a single dominant genetic factor largely governed disease risk. For Greyhounds, Rottweilers, and Irish Wolfhounds, a 2013 genome-wide association study found multiple genetic markers in each breed, with each marker only weakly associated with the disease.We obtained from two breeders the pedigrees, age (if alive) or age at death, and osteosarcoma status for two families of Scottish Deerhounds, designated Cohorts K and T. A dog was considered unaffected only if it was osteosarcoma-free and at least 8.5 years old. We analyzed the data in two ways, by assuming either a single recessive genetic factor or a single dominant genetic factor with high penetrance.ResultsCohort K contained 54 evaluable dogs representing 12 litters. Cohort T contained 56 evaluable dogs representing eight litters. Osteosarcoma seemed clearly heritable in both cohorts; however, having a parent with osteosarcoma raised a pup’s risk of developing osteosarcoma to 38% for Cohort K but 78% for Cohort T, suggesting the possibility of different genetic risk factors in each cohort. In Cohort K, osteosarcoma inheritance fit well with a single, recessive, autosomal risk factor, although we could not rule out the possibility of a single dominant risk factor with incomplete penetrance. In Cohort T, inheritance could be explained well by a single, dominant, autosomal risk factor but was inconsistent with recessive expression.ConclusionsInheritance of osteosarcoma in two Scottish Deerhound families could be explained well by a single genetic risk factor residing on an autosome, consistent with a 2007 report. In one family, inheritance was consistent with dominant expression, as previously reported. In the other family, inheritance fit better with recessive expression, although the possibility of a dominant genetic factor influenced by one or more other genetic factors could not be ruled out. In either case, the results suggest that there may be at least two different genetic risk factors for osteosarcoma in Deerhounds.

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A novel locus for canine osteosarcoma (OSA1) maps to CFA34, the canine orthologue of human 3q26

Cited by 33 publications

References 26 publications

Naturally occurring melanomas in dogs as models for non‐UV pathways of human melanomas

Naturally occurring melanomas in dogs as models for non‐UV pathways of human melanomas

Germline gene polymorphisms predisposing domestic mammals to carcinogenesis

Osteosarcoma inheritance in two families of Scottish deerhounds

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