A novel lncRNA SOX2OT promotes the malignancy of human colorectal cancer by interacting with miR-194-5p/SOX5 axis

Feng, Yan; Xü, Ying; Gao, Yongjian; Chen, Yiying; Wang, Xuefeng; Chen, Zhi

doi:10.1038/s41419-021-03756-y

Cited by 14 publications

(6 citation statements)

References 31 publications

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“…Interestingly, the important SOX5 role was also revealed in PCa oncogenesis and development ( 34 , 35 ). Interestingly, the miR-194-5p/SOX5 axis has been found to participate in the progression of colorectal cancer ( 36 ). All these data may indicate that the lncRNA SGMS1-AS1/miR-194-5p/SOX5 regulatory axis may also be crucial in PCa progression.…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis of the SOX family-related prognostic signature and immunological infiltration in prostate cancer

Li,

Wang

2023

Transl Cancer Res

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Background Prostate cancer (PCa) remains a major prevalent cancer worldwide and has a poor prognosis. The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family is a series of transcription factors (TFs) involved in regulating many biological processes (BPs). In tumors, however, SOX genes are frequently deregulated. Tumorigenic deregulation took place at the transcriptional, translational, and posttranslational levels. This leads them to be correlated to tumor progression and poor clinical outcomes in PCa. Nevertheless, the SOX family prognostic role in PCa still needs further investigation. Methods A SOX family-related prognostic signature was developed by performing LASSO (Least absolute shrinkage and selection operator) Cox regression analysis. The construction of a lncRNA-miRNA-mRNA regulatory axis for PCa was performed using a ceRNA network. Results Upregulation was observed in the expression of SOX4/8/11/12/14, while downregulation was observed for SOX2/5/7/13/15/30 in PCa. Consensus clustering identified four clusters of PCa patients based on these differentially expressed SOX family members. The constructed SOX family-related prognostic signature, which includes five SOX family members (SOX5/8/11/12/30), performed well in predicting PCa-patient prognosis. B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cell immune infiltration levels had a significant association with PCa-patient risk scores. Based on additional analysis, a significant association was also suggested between SOX family expression and tumor mutational burden (TMB), microsatellite instability (MSI), and drug sensitivity. By constructing a ceRNA network, a lncRNA SGMS1-AS1/miR-194-5p/SOX5 regulatory axis was developed for PCa. Conclusions Herein, a SOX family-related prognostic signature was identified and was found to perform well in predicting PCa-patient prognosis. A lncRNA SGMS1-AS1/miR-194-5p/SOX5 regulatory axis was also identified for PCa progression.

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Section: Discussionmentioning

confidence: 99%

Integrative analysis of the SOX family-related prognostic signature and immunological infiltration in prostate cancer

Li,

Wang

2023

Transl Cancer Res

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“…demonstrated a new triad involving SNHG17/miR-375/CBX3 that participates in the migration and invasion of COAD ( 190 ). SOX2OT,acting as a ceRNA, upregulates SOX5 through a sponge-like effect on miR-194-5p, regulating CRC cell migration and invasion ( 192 ). Sui et al.…”

Section: Lncrnas Regulate Invasion and Metastasismentioning

confidence: 99%

The functions and mechanisms of long non-coding RNA in colorectal cancer

Lin,

Zhao,

et al. 2024

Front. Oncol.

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CRC poses a significant challenge in the global health domain, with a high number of deaths attributed to this disease annually. If CRC is detected only in its advanced stages, the difficulty of treatment increases significantly. Therefore, biomarkers for the early detection of CRC play a crucial role in improving patient outcomes and increasing survival rates. The development of a reliable biomarker for early detection of CRC is particularly important for timely diagnosis and treatment. However, current methods for CRC detection, such as endoscopic examination, blood, and stool tests, have certain limitations and often only detect cases in the late stages. To overcome these constraints, researchers have turned their attention to molecular biomarkers, which are considered a promising approach to improving CRC detection. Non-invasive methods using biomarkers such as mRNA, circulating cell-free DNA, microRNA, LncRNA, and proteins can provide more reliable diagnostic information. These biomarkers can be found in blood, tissue, stool, and volatile organic compounds. Identifying molecular biomarkers with high sensitivity and specificity for the early and safe, economic, and easily measurable detection of CRC remains a significant challenge for researchers.

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“…Mechanistically, SOX2OT acts as a competing endogenous RNA (ceRNA), sponging miR-194-5p and upregulating the expression of SOX5. These findings highlight the potential of SOX2OT as a diagnostic marker and therapeutic target in CRC, impacting tumor aggressiveness and therapy response while also modulating the tumor microenvironment and immune regulation [ 133 , 134 ].…”

Section: The Role Of Lncrnas In Tumor–stroma Immune Interplay Via Ext...mentioning

confidence: 99%

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in the pathogenesis of CRC, immune evasion, and the treatment response to CRC, have crucial implications in inflammation and serve as promising candidates for novel therapeutic strategies and biomarkers. This review scrutinizes the interaction of lncRNAs with the Consensus Molecular Subtypes (CMSs) of CRC, their complex interplay with the tumor stroma affecting immunity and inflammation, and their conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into the intricate relationship between lncRNAs and other non-coding RNAs, including microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Lastly, we propose potential strategies to manipulate lncRNAs to enhance anti-tumor immunity, thereby underlining the significance of lncRNAs in devising innovative therapeutic interventions in CRC.

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A novel lncRNA SOX2OT promotes the malignancy of human colorectal cancer by interacting with miR-194-5p/SOX5 axis

Cited by 14 publications

References 31 publications

Integrative analysis of the SOX family-related prognostic signature and immunological infiltration in prostate cancer

Integrative analysis of the SOX family-related prognostic signature and immunological infiltration in prostate cancer

The functions and mechanisms of long non-coding RNA in colorectal cancer

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

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