A novel lncRNA derived from an ultraconserved region: lnc-<i>uc.147</i>, a potential biomarker in luminal A breast cancer

Zambalde, Érika Pereira; Bayraktar, Recep; Jucoski, Tayana Schultz; Ivan, Cristina; Rodrigues, Ana Carolina; Mathias, Carolina; Knutsen, Erik; Lima, Rubens Silveira de; Ribeiro, Enilze Maria de Souza Fonseca; Hannash, Samir M.; Calin, George A.; Oliveira, Juliana Gomes Ramalho de

doi:10.1080/15476286.2021.1952757

Cited by 9 publications

(9 citation statements)

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“…Uc.147 was previously highlighted by our group as an important lncRNA in breast cancer [ 26 ]. The silencing of uc.147 in luminal BC cell lines increases apoptosis, arrests cell cycle, and decreases colony formation and cell viability [ 26 ]. These experiments indicated that this T-UCR acts as an oncogene in BC cell lines.…”

Section: Discussionmentioning

confidence: 99%

“…Including a T-UCR transcriptional portrait, 12 T-UCRs (uc. 84, uc.138, uc.147, uc.193, uc.268, uc.271, uc.311, uc.376, uc.378, uc.427, uc.456, uc.475) were suggested to have great potential as biomarkers in BC, but these molecules were not further investigated [26]. The present study aimed to evaluate the 12 T-UCRs in the TCGA data and the Brazilian cohort.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the BC general classification system and the existing guidelines for the stratification of patients inside each group, the wide range of diversity observed in each subtype demands additional molecular markers to offer personalized therapy and improve BC survival rates [ 22 , 23 ]. In addition, only four T-UCRs have been strongly associated with BC: uc.38, downregulated BC patients [ 24 ], uc.63, upregulated in luminal A patients associated with poor prognosis [ 25 ], lnc-uc.147, associated with poor prognosis in luminal A [ 26 ], and uc.51, associated to metastasis [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…In a previous study from our group, we evaluated the expression level of all 481 T-UCRs in TCGA (The Cancer Genome Atlas) BC patients and found that 63% of transcripts correlated with some clinical and/or molecular parameter of BC [ 26 ]. Including a T-UCR transcriptional portrait, 12 T-UCRs (uc.84, uc.138, uc.147, uc.193, uc.268, uc.271, uc.311, uc.376, uc.378, uc.427, uc.456, uc.475) were suggested to have great potential as biomarkers in BC, but these molecules were not further investigated [ 26 ]. The present study aimed to evaluate the 12 T-UCRs in the TCGA data and the Brazilian cohort.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transcribed Ultraconserved Regions Are Associated with Clinicopathological Features in Breast Cancer

et al. 2022

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Ultraconserved regions (UCRs) are 481 genome segments, with length longer than 200 bp, that are 100% conserved among humans, mice, and rats. The majority of UCRs are transcriptionally active (T-UCRs) as many of them produce non-coding RNAs. In a previous study, we evaluated the expression level of T-UCRs in breast cancer (BC) patients and found that 63% of transcripts correlated with some clinical and/or molecular parameter of BC. In this study, we delved into the expression levels of 12 T-UCRs and correlated them with clinicopathological parameters, immunohistochemical markers, and overall survival in two breast cancer cohorts: TCGA and Brazilian patients. We found that uc.268 is more expressed in TCGA patients under 40 years of age, associated with progesterone receptor (PR) and estrogen receptor (ER), and its high expression is found in luminal A. Lower uc.84 and uc.376 were respectively observed in metastatic and stage IV tumors associated with good prognostic in luminal B. Moreover, uc.84 was only related to the HER2+, while uc.376 was related to ER+ and PR+, and HER2+. A panel composed of uc.147, uc.271, and uc.427 distinguished luminal A from triple negative patients with an AUC of 0.9531 (sensitivity 92.19% and specificity 86.76%). These results highlight the potential role of T-UCRs in BC and provide insights into the potential application of T-UCRs as biomarkers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transcribed Ultraconserved Regions Are Associated with Clinicopathological Features in Breast Cancer

et al. 2022

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Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential

Wang

2023

Discov Onc

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Ultra-conserved RNA (ucRNA) is a subset of long non-coding RNA, that is highly conserved among mice, rats and humans. UcRNA has attracted extensive attention in recent years for its potential biological significance in normal physiological function and diseases. However, due to the instability of RNA and the technical limitation, the function and mechanism of ucRNAs are largely unknown. Over the last two decades, researchers have made a lot of efforts to try to lift the veil of ucRNA in nervous, cardiovascular system and other systems as well as cancers. Since the concept of the glymphatic system is relatively new, we summarized here recent findings on the functions, regulation and the underlying mechanisms of ucRNAs in physiology and pathology. Meanwhile, pathology in some diseases is likely to contribute to abnormal expression of ucRNA in turn. We also discuss the technical challenges and bright prospects for future applications of ucRNAs in the diagnosis and treatment of diseases.

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The dark matter of the human genome and its role in human cancers

Bozgeyik

2022

Gene

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A novel lncRNA derived from an ultraconserved region: lnc-uc.147, a potential biomarker in luminal A breast cancer

Cited by 9 publications

References 116 publications

Transcribed Ultraconserved Regions Are Associated with Clinicopathological Features in Breast Cancer

Transcribed Ultraconserved Regions Are Associated with Clinicopathological Features in Breast Cancer

Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential

The dark matter of the human genome and its role in human cancers

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