A novel leukocyte adhesion deficiency type III mutation manifests functional importance of the compact FERM domain in kindlin-3

Xu, Zhen; Jobe, Shawn M.; Ma, Yan-Qing; Shavit, Jordan A.

doi:10.1016/j.jtha.2023.10.013

Journal of Thrombosis and Haemostasis

2024

DOI: 10.1016/j.jtha.2023.10.013

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A novel leukocyte adhesion deficiency type III mutation manifests functional importance of the compact FERM domain in kindlin-3

Zhen Xu,

Shawn M. Jobe,

Yan-Qing Ma

et al.

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2024

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Functional neutrophil disorders: Chronic granulomatous disease and beyond

Zerbe,

Holland

2024

Immunological Reviews

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SummarySince their description by Metchnikoff in 1905, phagocytes have been increasingly recognized to be the entities that traffic to sites of infection and inflammation, engulf and kill infecting organisms, and clear out apoptotic debris all the while making antigens available and accessible to the lymphoid organs for future use. Therefore, phagocytes provide the gateway and the first check in host protection and immune response. Disorders in killing and chemotaxis lead not only to infection susceptibility, but also to autoimmunity. We aim to describe chronic granulomatous disease and the leukocyte adhesion deficiencies as well as myeloperoxidase deficiency and G6PD deficiency as paradigms of critical pathways.

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Functional neutrophil disorders: Chronic granulomatous disease and beyond

Zerbe,

Holland

2024

Immunological Reviews

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A novel leukocyte adhesion deficiency type III mutation manifests functional importance of the compact FERM domain in kindlin-3

Cited by 1 publication

References 21 publications

Functional neutrophil disorders: Chronic granulomatous disease and beyond

Functional neutrophil disorders: Chronic granulomatous disease and beyond

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