A novel layered double hydroxide-hesperidin nanoparticles exert antidiabetic, antioxidant and anti-inflammatory effects in rats with diabetes

El-Shahawy, Ahmed A. G.; Abdel-Moneim, Adel; Ebeid, Abdelazim S M; Eldin, Zienab E.; Zanaty, Mohamed I.

doi:10.1007/s11033-021-06527-2

Cited by 17 publications

(4 citation statements)

References 58 publications

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“…To enhance the sustained release and potency of hesperidin as a potential anti-diabetic agent compared to conventional treatments, a new hesperidin nano-carrier was prepared and characterized. When administered to diabetic rats, this formulation exhibited prolonged production of hesperidin and resulted in improvements in glycemia, HbA1c levels, insulin levels, and lipid profile [ 219 ].…”

Section: In Vivo and In Vitro Anti-diabet...mentioning

confidence: 99%

Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus

Bouyahya,

Balahbib,

Khalid

et al. 2024

Heliyon

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Section: In Vivo and In Vitro Anti-diabet...mentioning

confidence: 99%

Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus

Bouyahya,

Balahbib,

Khalid

et al. 2024

Heliyon

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“…Blood glucose levels were examined with capillary blood collection equipment (Easy Touch GCU No.GOS22211861) strip test method and the results were expressed in mg/dL units. 8 TNF-α Level Check TNF-α levels were examined by the Enzyme-Linked Immunosorbent Assay 9 (ELISA, Rats Tumor Necrosis Factor α, TNF-α BT-LAB Kit Cat. No.…”

Section: Glucose Level Checkmentioning

confidence: 99%

Evaluation of the Effect of Cow’s Milk Kefir on Serum Tumor Necrosis Factor-alpha (TNF-α) and Expression of Inducible Nitric Oxide Synthase (iNOS) Gene in Liver Rats

2023

TJNPR

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Chronic hyperglycemia in DM is associated with long-term damage, impaired function, and malfunction of various organs, in particular hepatic, kidneys, nerves, heart, and blood vessels. 1 There is an increase in TNF-α production in the pathogenesis of DM. 2 This increase in TNF-α levels occurs due to the dysregulation of the work of insulin so that hepar glucose production increases and causes chronic hyperglycemia. The increase in TNF-α levels in hepar also causes an increase in the activity of Inducible Nitric Oxide Synthase (iNOS) or known as NOS2 in the liver by 45-70% through up-regulation of the Nuclear Transcription Factor pathway. 3 Kefir seeds are a mixture of lactic acid bacteria (Lactobacilli, Lactococci, Lactobacillus kefir, Lactobacillus parakefir, Lactobacillus kefiranofaciens, and Lactobacillus kefirgramum) with yeast and acetic acid bacteria. 4 Supplementation of clear kefir at a dose of 3.6 mL / 200 grams of body weight for 4 weeks can lower blood glucose levels and levels of proinflammatory cytokines such as IL-1, IL-6, IL-8 in Wistar hyperglycemia rats induced with streptozotocin. 5

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“…To the best of our knowledge, limited trials have been conducted to increase the solubility of Hsd via complexation. At the same time, few studies reported the heightened antidiabetic activity of Hsd NPs [ 37 – 39 ]. Hence, this study is the first one aimed to enhance the solubility of Hsd by its complexation with SBE-β-CD.…”

Section: Introductionmentioning

confidence: 99%

Enhanced oral delivery of hesperidin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for augmenting its hypoglycemic activity: in vitro-in vivo assessment study

Elmoghayer,

Saleh,

Abu Hashim

2023

Drug Deliv. and Transl. Res.

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Hesperidin (Hsd), a bioactive phytomedicine, experienced an antidiabetic activity versus both Type 1 and Type 2 Diabetes mellitus. However, its intrinsic poor solubility and bioavailability is a key challenging obstacle reflecting its oral delivery. From such perspective, the purpose of the current study was to prepare and evaluate Hsd-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles (Hsd/CD/CS NPs) for improving the hypoglycemic activity of the orally administered Hsd. Hsd was first complexed with sulfobutylether-β-cyclodextrin (SBE-β-CD) and the complex (CX) was found to be formed with percent complexation efficiency and percent process efficiency of 50.53 ± 1.46 and 84.52 ± 3.16%, respectively. Also, solid state characterization of the complex ensured the inclusion of Hsd inside the cavity of SBE-β-CD. Then, Hsd/CD/CS NPs were prepared using the ionic gelation technique. The prepared NPs were fully characterized to select the most promising one (F1) with a homogenous particle size of 455.7 ± 9.04 nm, a positive zeta potential of + 32.28 ± 1.12 mV, and an entrapment efficiency of 77.46 ± 0.39%. The optimal formula (F1) was subjected to further investigation of in vitro release, ex vivo intestinal permeation, stability, cytotoxicity, and in vivo hypoglycemic activity. The results of the release and permeation studies of F1 manifested a modulated pattern between Hsd and CX. The preferential stability of F1 was observed at 4 ± 1 °C. Also, the biocompatibility of F1 with oral epithelial cell line (OEC) was retained up to a concentration of 100 µg/mL. After oral administration of F1, a noteworthy synergistic hypoglycemic effect was recorded with decreased blood glucose level until the end of the experiment. In conclusion, Hsd/CD/CS NPs could be regarded as a hopeful oral delivery system of Hsd with enhanced antidiabetic activity. Graphical Abstract

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A novel layered double hydroxide-hesperidin nanoparticles exert antidiabetic, antioxidant and anti-inflammatory effects in rats with diabetes

Cited by 17 publications

References 58 publications

Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus

Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus

Evaluation of the Effect of Cow’s Milk Kefir on Serum Tumor Necrosis Factor-alpha (TNF-α) and Expression of Inducible Nitric Oxide Synthase (iNOS) Gene in Liver Rats

Enhanced oral delivery of hesperidin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for augmenting its hypoglycemic activity: in vitro-in vivo assessment study

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