A novel Lactobacillus plantarum strain P-8 activates beneficial immune response of broiler chickens

Wang, Lifeng; Liu, Caihong; Ma, Castello; Tuo, Ya; Huang, Weiqiang; Gao, Pengfei; Zhang, Heping

doi:10.1016/j.intimp.2015.07.024

Cited by 57 publications

(46 citation statements)

References 43 publications

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“…In addition, there were no differences in the leucocyte count among the treatments of the control, LAB and smectite groups, showing that the protection by two adsorbing agents to the body via leucocytes induces immune responses. This is supported by reports by Zulkifli et al (2010) and Wang et al (2015) showing that LAB can activate protective immune responses through cytokines.…”

Section: Discussionsupporting

confidence: 67%

“…() and Wang et al. () showing that LAB can activate protective immune responses through cytokines. Additionally, the erythrocytes count and haemoglobin were also reversely affected by the AFB 1 challenge and adsorbing agents, suggesting that dietary factors may influence erythrocyte development from stem cells, further maturation or haemoglobin biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

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Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Liu

Ding

Wang

et al. 2018

Animal Physiology Nutrition

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This study aimed to investigate the effect of lactic acid bacteria (LAB) and smectite on the growth performance, nutrient digestibility and blood parameters of broilers that were fed diets contaminated with aflatoxin B (AFB ). A total of 480 newly hatched male Arbor Acres broilers were randomly allocated into four groups with six replicates of 20 chicks each. The broilers were fed diets with the AFB (40 μg/kg) challenge or without (control) it and supplemented with smectite (3.0 g/kg) or LAB (4.0 × 10 CFU/kg) based on the AFB diet. The trial lasted for 42 days. The results showed that during days 1-42 of AFB challenge, the feed intake (FI) and body weight gain (BWG) were depressed (p < .05). The inclusion of LAB and smectite increased (p < .05) the BWG by 71.58 and 41.89 g/bird, respectively, which reached the level of the control diet (p ≥ .05), but there were no differences (p ≥ .05) in performance between LAB and smectite. LAB and smectite also increased (p < .05) the apparent total tract digestibility of the crude protein. Regarding the blood parameters, AFB decreased (p < .05) the levels of red blood cell count, haematocrit, mean corpuscular volume, haemoglobin, albumin and total protein. In the meantime, the AFB increased (p < .05) leucocyte counts, urea nitrogen, cholesterol, total bilirubin, creatinine, glutamic-pyruvic transaminase, glutamic oxaloacetic transaminase and alkaline phosphatase. By contrast, LAB and smectite affected (p < .05) these parameters in the opposite direction. It can be concluded that after the AFB challenge, LAB and smectite have similar effects on the growth and health of the broilers, suggesting that LAB could be an alternative against AFB in commercial animal feeds.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Liu

Ding

Wang

et al. 2018

Animal Physiology Nutrition

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“…E.tenella has capability to prompt anti-apoptosis factor Bcl-xL and nuclear transcriptional factor NF-κB to protect their cells and growing in its second generation schizonts and can be act as antagonists by enhancing the activity of NF-κB which is responsible for regulating numerous anti-apoptosis proteins such as Bcl-xL, Bcl-2 and Mcl-1 [35]. Previous studies reported that Probiotics and herbs revealed ameliorative effects on apoptosis by prompting pro-apoptosis proteins conversely inhibiting anti-apoptosis elements [36,37]. In order to search the apoptotic mechanism between treated and un-treated chickens, we have explored the expressions of Bcl-2, Bax and Caspase-3.…”

Section: Discussionmentioning

confidence: 99%

Effects of probiotics and Bidens pilosa on the performance and gut health of chicken during induced E. tenella infection

Memon

Yang

et al. 2020

Preprint

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Background Probiotics and Medicinal plants are widely used as an alternative to treat different kinds of the acute and chronic diseases in all over the world. Bidens pilosa is commonly used as foods and therapeutics against various pathogens including protozoan. In the present study probiotics and Bidens pilosa were used to explore the anticoccidial activity during experimental infection of Eimeria tenella ( E. tenella ) in chicken Methods One hundred and fifty one-day-old Chinese yellow breed chickens were divided into five equal groups. Group 1 was kept as control group (CG; un-treated, unchallenged). All other groups were inoculated with E. tenella sporulated oocysts on day 21 of age. Group 2 was kept as positive control (CPG; un-treated, challenged). Group 3 was treated with probiotics (PG) at the rate of 1g/kg of feed. Group 4 was treated with Bidens pilosa (BPG) at the dose of 0.5%/kg of feed. Group 5 was kept as probiotics + Bidens pilosa group (PG + BPG). All birds were weighed initially, day of infection and the final day of experiment. On day 5, 6, 7 and 8 post-infection (PI), bloody diarrhea was scored as normal (0) to sever (1, 2, 3 and 4), at the same time oocysts shedding was quantified by McMaster method. Gross caecal lesion scoring was checked at the final day of experiment. The apoptosis related gene expressions (Bcl-2, Bax, Caspase-3), anti-oxidant enzymatic expressions (CAT, SOD 1), Peptide transporter 1 (PepT 1), pro-inflammatory cytokines (IL-6, IL-8) and tight junction proteins expressions (CLDN 1, ZO 1) were checked by real time PCR. All related gene expressions average relative to β-actin was calculated by 2−ΔΔCt method. Results Birds treated with probiotics, Bidens pilosa and probiotics + Bidens pilosa slightly increased the body weight gain, significantly reduced oocysts shedding, destructive ratio of ceaca and mortality % than control positive group. CPG birds up-regulated the expressions of Bcl-2 while down-regulated the expressions of Bax and caspase-3 as compared to PG, BPG and PG + BPG groups. Moreover, Eimeria challenged chickens supplemented with probiotics, Bidens pilosa alone and combined showed higher anti-oxidant enzymatic activity than those of challenged un-treated chickens. Additionally, the expressions of pro-inflammatory cytokines and tight junction related proteins were also up-regulated by the treated challenged than un-treated challenged chickens. Conclusion Present results revealed that, feed supplementation of probiotics and Bides pilosa induced apoptosis, enhanced anti-oxidant enzymatic activity and pro-inflammatory cytokines as well as tight junction proteins and reduce mortality during E.tenella infection in chickens.

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“…Activated NF-κB and MAPK stimulate synthesis of anti- and proinflammatory cytokines, including IL-10, IL-1β, TNF-a, IL-6 and IL-8, etc. [3, 8, 22–24, 31]. Thus, it will be interesting to explore whether NF-κB and MAPK are involved in L. acidophilus -mediated regulation on inflammatory response to ETEC .…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets

Zhang

Chen

et al. 2016

BMC Microbiol

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BackgroundA newly isolated L. acidophilus strain has been reported to have potential anti-inflammatory activities against lipopolysaccharide (LPS) challenge in piglet, while the details of the related inflammatory responses are limited. Here we aimed to analysis the ability of L. acidophilus to regulate inflammatory responses and to elucidate the mechanisms involved in its anti-inflammatory activity.ResultsThe ETEC (enterotoxigenic Escherichia coli) K88-induced up-regulations of IL-1β, IL-8 and TNF-α were obviously inhibited by L. acidophilus while IL-10 was significantly increased. Moreover, L. acidophilus down-regulated pattern recognition receptors TLR (Toll-like receptor) 2 and TLR4 expression in both spleen and mesenteric lymph nodes of ETEC-challenged piglets, in accompanied with the reduced phosphorylation levels of nuclear factor kappa B (NF-κB) p65 and mitogen-activated protein kinase (MAPK) p38 as well in spleen of ETEC-infected piglets. Furthermore, L.acidophilus significantly increased the expression of the negative regulators of TLRs signaling, including Tollip, IRAK-M, A20 and Bcl-3 in spleen of ETEC-challenged piglets.ConclusionsOur findings suggested that L. acidophilus regulated inflammatory response to ETEC via impairing both NF-κB and MAPK signaling pathways in piglets.

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A novel Lactobacillus plantarum strain P-8 activates beneficial immune response of broiler chickens

Cited by 57 publications

References 43 publications

Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Effects of probiotics and Bidens pilosa on the performance and gut health of chicken during induced E. tenella infection

Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets

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A novel Lactobacillus plantarum strain P-8 activates beneficial immune response of broiler chickens

Cited by 57 publications

References 43 publications

Effects of lactic acid bacteria and smectite after aflatoxin B1 challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Effects of lactic acid bacteria and smectite after aflatoxin B1 challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Effects of probiotics and Bidens pilosa on the performance and gut health of chicken during induced E. tenella infection

Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets

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Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers