A novel laccase with inhibitory activity towards HIV‐I reverse transcriptase and antiproliferative effects on tumor cells from the fermentation broth of mushroom <i>Pleurotus cornucopiae</i>

Wu, Xiangli; Huang, Chenyang; Chen, Qiang; Wang, Hexiang; Zhang, Jinxia

doi:10.1002/bmc.3068

Cited by 26 publications

(9 citation statements)

References 31 publications

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“…And the full potential of laccases is yet to be reached as the novel applications continue to flow. Very recently, new and existing laccases from different fungal species have shown medicinal application, with the ability to inhibit HIV−I reverse transcriptase, as well as exhibiting antiproliferative and cytotoxic effects on tumor cells . Thus, laccases are truly enzymes that keep giving, and we are excited to discover the innovative ways in wich laccases can continue to advance sustainability in the chemical industry and beyond.…”

Section: Discussionmentioning

confidence: 99%

Two Decades of Laccases: Advancing Sustainability in the Chemical Industry

Cannatelli

Ragauskas

2016

Chem. Rec.

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Given the current state of environmental affairs and that our future on this planet as we know it is in jeopardy, research and development into greener and more sustainable technologies within the chemical and forest products industries is at its peak. Given the global scale of these industries, the need for environmentally benign practices is propelling new green processes. These challenges are also impacting academic research and our reagents of interest are laccases. These enzymes are employed in a variety of biotechnological applications due to their native function as catalytic oxidants. They are about as green as it gets when it comes to chemical processes, requiring O as their only co-substrate and producing H O as the sole by-product. The following account will review our twenty year journey on the use of these enzymes within our research group, from their initial use in biobleaching of kraft pulps and for fiber modification within the pulp and paper industry, to their current application as green catalytic oxidants in the field of synthetic organic chemistry.

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Section: Discussionmentioning

confidence: 99%

Two Decades of Laccases: Advancing Sustainability in the Chemical Industry

Cannatelli

Ragauskas

2016

Chem. Rec.

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“…Laccases from the mushrooms Lentinus edodes and Pleurotus cornucopiae revealed inhibitory activity toward HIV-1 reverse transcriptase Sun et al 2011;Wu et al 2014). …”

Section: Laccasesmentioning

confidence: 95%

Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes

Cheung

Wong

et al. 2015

Appl Microbiol Biotechnol

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Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, has claimed innumerable lives in the past. Many biomolecules which suppress HIV replication and also other biomolecules that inhibit enzymes essential to HIV replication have been reported. Proteins including a variety of milk proteins, ribosome-inactivating proteins, ribonucleases, antifungal proteins, and trypsin inhibitors; peptides comprising cathelicidins, defensins, synthetic peptides, and others; polysaccharides and polysaccharopeptides; nucleosides, nucleotides, and ribozymes, demonstrated anti-HIV activity. In many cases, the mechanism of anti-HIV action has been elucidated. Strategies have been devised to augment the anti-HIV potency of these compounds.

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“…Besides, from the fermentation broth of P. cornucopiae was isolated a new laccase with a molecular mass of 67 KDa. It inhibited proliferation of the hepatoma cells HepG2, the breast cancer cells MCF-7, and the activity of HIV-I reverse transcriptase with IC50 values of 3.9, 7.6 and, 3.7 lM, respectively (Wu et al 2014). Besides, a divalent cation-dependent GalNAc-specific lectin (PCL-M) was purified from the mycelia of P. cornucopiae.…”

Section: Proteins Peptides and Lectinsmentioning

confidence: 99%

Mycochemicals in wild and cultivated mushrooms: nutrition and health

et al. 2021

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The mushrooms have contributed to the development of active ingredients of fundamental importance in the field of pharmaceutical chemistry as well as of important tools in human and animal health, nutrition, and functional food. This review considers studies on the beneficial effects of medicinal mushrooms on the nutrition and health of humans and farm animals. An overview of the chemical structure and composition of mycochemicals is presented in this review with particular reference to phenolic compounds, triterpenoids and sterols, fatty acids and lipids, polysaccharides, proteins, peptides, and lectins. The nutritional value and chemical composition of wild and cultivated mushrooms in Italy is also the subject of this review which also deals with mushrooms as nutraceuticals and the use of mushrooms in functional foods. The nutraceutical benefits of UV irradiation of cultivated species of basidiomycetes to generate high amounts of vitamin D2 is also highlighted and the ability of the muhsrooms to inhibit glycation is analyzed. Finally, attention is paid to studies on bioactivities of some Italian wild and cultivated mushrooms with particular reference to species belonging to the genus Pleurotus. The review highlights the potential of medicinal mushrooms in the production of mycochemicals that represent a source of drugs, nutraceutical, and functional food. Graphic abstract

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A novel laccase with inhibitory activity towards HIV‐I reverse transcriptase and antiproliferative effects on tumor cells from the fermentation broth of mushroom Pleurotus cornucopiae

Cited by 26 publications

References 31 publications

Two Decades of Laccases: Advancing Sustainability in the Chemical Industry

Two Decades of Laccases: Advancing Sustainability in the Chemical Industry

Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes

Mycochemicals in wild and cultivated mushrooms: nutrition and health

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