A novel iron supplements preparation from Grifola frondosa polysaccharide and assessment of antioxidant, lymphocyte proliferation and complement fixing activities

Xu, Lei; Meng, Yongbin; Liu, Ying; Meng, Qinghuan; Zhang, Zidong; Li, Jian; Lü, Qi

doi:10.1016/j.ijbiomac.2017.10.163

Cited by 39 publications

(34 citation statements)

References 57 publications

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“…These results demonstrate that the AAPS-iron(III) complex maintained high thermal stability in the temperature ranging from 50°C to 256°C, indicating that the AAPS-iron(III) complex is sufficiently stable if used as a type of nutritional fortifiers which are generally required to be stable below 250°C in the food industry. Similar thermal stability was also reported in Grifola frondosa [13], where the AAPS-iron(III) complex showed increased high stability in the temperature ranging from room temperature to 275°C in comparison to AAPS.…”

Section: Resultssupporting

confidence: 84%

“…The optimum preparation conditions of the AAPS-iron(III) complex included a ratio of AAPS to FeCl 3 ∙ 6H 2 O of 2:3 (w/w), pH 8.0, reaction temperature of 50°C, and reaction time of 3 h. The AAPS-iron(III) complex had a relatively high iron content (28.40%) compared to those previously reported and showed increased water solubility. For example, Xu et al [13] have obtained iron content of 24.15% in the AAPS-iron(III) complex in a fungal species of Grifola frondosa under the optimum preparation conditions based on the single factor and orthogonal optimization experiments, including a ratio of AAPS to the catalyst (sodium citrate) of 1:1 (g/g), reaction temperature of 80°C, reaction time of 1.5 h, and pH 8.0.…”

Section: Resultsmentioning

confidence: 99%

“…The interest of polysaccharides of natural origin has expanded into the areas of anticancer, antitumor, antioxidant, antiobesity, neuroprotective, antimicrobial, and anti-inflammatory, with broadened fields of applications of these polysaccharides in food supplements, cosmetics, pharmaceuticals, and biomedical uses [11, 12]. Recent studies have documented polysaccharide-iron(III) complexes with high stability and increased bioavailability in comparison to those of currently commonly used oral iron supplement, e.g., ferrous sulfate [13]. Polysaccharide-iron complexes have been the most studied among all of the iron(III) complexes because they have high stability and water solubility, and more important, reduced side effects [14, 15].…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement

Liu

et al. 2019

BioMed Research International

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Iron deficiency anemia has been a widespread disease. As an effective and stable iron supplement, the physiochemical properties of the polysaccharide iron complex have been widely studied. In this study, we characterized a novel polysaccharide-iron(III) complex extracted in an edible fungal species Auricularia auricular (AAPS-iron(III)). The highest iron content (28.40%) in the AAPS-iron(III) complex was obtained under the optimized preparation conditions including an AAPS to FeCl3∙6H2O ratio of 2:3 (w/w), a pH value of 8.0 in solution, a reaction temperature of 50°C, and a reaction time of 3 h. The physical and chemical properties of the AAPS-iron(III) complex were characterized by qualitative and quantitative analyses using scanning electron microscope, particle size distribution, thermogravimetric analyzer, Fourier transform infrared spectroscopy, circular dichroism, and 1H nuclear magnetic resonance. Result showed that, although the iron was bound to the polysaccharide, it was released under artificial gastrointestinal conditions. The AAPS-iron(III) complex exhibited high stability (under 50-256°C) and water solubility. The AAPS-iron(III) complex also showed high antioxidant activity in vitro, demonstrating an additional health benefit over other typical nonantioxidant iron nutritional supplements. Furthermore, the AAPS-iron(III) complex showed high efficiency on the treatment of the iron deficiency anemia in the model rats. Therefore, the AAPS-iron(III) complex can be used as a nutritional fortifier to supply iron in industrial processing and to assist the treatment of iron deficiency anemia.

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement

Liu

et al. 2019

BioMed Research International

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“…AOS had an absorption peak at 1725 cm −1 (–COOH) (Dolamic et al ., ) that was absent in the AOS–iron (III) spectrum, which indicates that –COOH might be chelated with iron (III). In addition, bands at 1636 and 1412 cm −1 in the AOS spectrum indicated the presence of a free carboxylic carbonyl group (Siqueira et al ., ; Pouyet et al ., ) and carboxylic acids group (Xu et al ., ), respectively. In the AOS–iron (III) spectrum, the two peaks showed some migration (1605 and 1386 cm −1 ), which means that iron (III) and AOS might be combined by the –OH groups (Tang et al ., ).…”

Section: Resultsmentioning

confidence: 95%

“…Iron content was highest (11.89 ± 0.24%) at the mass ratio of 2:1 g:g. Sodium citrate and AOS are ligands for iron (III) (Gautier‐Luneau et al ., ; Wang et al ., ). Sodium citrate acts as a bridge to link AOS and iron (III), and then it separates from AOS–iron (III) (Xu et al ., b). Therefore, sodium citrate was available for further reaction to get more AOS–iron (III).…”

Section: Resultsmentioning

confidence: 99%

Preparation and characterisation of a novel agar oligosaccharide–iron (III) complex

Teng

et al. 2018

Int J of Food Sci Tech

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This study aimed to synthesise a complex of agar oligosaccharides (AOS) with ferric iron and to evaluate its physicochemical and structural characteristics. Based on single factor, Plackett-Burman and response surface optimal experiments of three factors at three levels, the optimised chelate conditions of the AOSiron (III) complex were mass ratio of AOS to iron ions of 4.5:1 g:g, reaction temperature of 74°C and reaction time of 60 min. Under these conditions, the iron content and total sugar content were 14.03 AE 0.42% and 66.07 AE 0.96%, respectively. The physicochemical analysis showed that AOS-iron (III) was soluble and steady at physiological pH, and it was easily reduced to iron (II). The structural characteristics of AOS and AOS-iron (III) were analysed by Raman spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction and Nuclear magnetic resonance, and results showed that the iron (III) ions were chelated to AOS by -OH groups and -COOH groups and widely dispersed on the AOS backbone. Therefore, AOS-iron (III) could be a candidate for iron supplementation to treat iron deficiency anaemia.

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Preparation of Rehmanniae Radix Praeparata Polysaccharide Iron(III) Complex and Evaluation of Its Biological Activity

Liu,

Chen

et al. 2024

Chemistry & Biodiversity

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This study extracted and purified a polysaccharide from Rehmanniae radix praeparata (RGP) with an average molecular weight. The structural characteristics of RGP and its iron(III) complex, RGP‐Fe(III), were examined for their antioxidant properties and potential in treating iron deficiency anemia (IDA). Analysis revealed that RGP comprised Man, Rha, Gal, and Xyl, with a sugar residue skeleton featuring 1→3; 1→2, 3; and 1→2, 3, 4 linkages, among others. RGP‐Fe(III) had a molecular weight of 4.39×104 Da. Notably, RGP‐Fe(III) exhibited superior antioxidant activity compared to RGP alone. In IDA rat models, treatment with RGP‐Fe(III) led to increased weight gain, restoration of key blood parameters including hemoglobin, red blood cells, and mean hemoglobin content, elevated serum iron levels, and decreased total iron‐binding capacity. Histological examination revealed no observable toxic effects of RGP‐Fe(III) on the liver and spleen. These findings suggest the potential of RGP‐Fe(III) as a therapeutic agent for managing IDA and highlight its promising antioxidant properties.

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A novel iron supplements preparation from Grifola frondosa polysaccharide and assessment of antioxidant, lymphocyte proliferation and complement fixing activities

Cited by 39 publications

References 57 publications

Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement

Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement

Preparation and characterisation of a novel agar oligosaccharide–iron (III) complex

Preparation of Rehmanniae Radix Praeparata Polysaccharide Iron(III) Complex and Evaluation of Its Biological Activity

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