A novel intratumoral pH/redox-dual-responsive nanoplatform for cancer MR imaging and therapy

Wan, Lihui; Chen, Zhongyin; Deng, Yan; Liao, Tao; Kuang, Ying; Liu, Jia; Duan, Junlin; Xu, Ziqiang; Jiang, Bingbing; Li, Cao

doi:10.1016/j.jcis.2020.04.026

Cited by 31 publications

(16 citation statements)

References 46 publications

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“…Chemotherapy, as the most widely used method for cancer treatment, destroys both cancerous and normal cells and causes severe side effects 3 . On the other hand, a small portion of the introduced drug is delivered to the tumor tissues diminishing the efficiency of chemotherapy 4 . This causes the drug to be prescribed in higher doses, which leads to the systematic removal of drug from the body and is not affordable 5,6 .…”

Section: Introductionmentioning

confidence: 99%

“…Targeted nano-drug delivery systems with small sizes (10 to 100 nm) enhance permeation through the newborn blood vessels of tumor tissues with slower clearance due to the lack of lymph 12 . These drug nanocarriers including micelles 13,14 , polymersomes 15 , liposomes 16 , dendrimers 17 , carbon nanotubes 18 , magnetic nanoparticles 19 and silica nanoparticles 20,21 are of high importance because of their higher permeability, detection of target cells, accumulation at cancer sites, less side effects, and more efficient treatment 4,5,22 .…”

Section: Introductionmentioning

confidence: 99%

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One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Baghbanbashi¹,

Pazuki²,

Khoee³

2021

Preprint

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Providing an efficient system for drug delivery and chemotherapy has always been an important issue. Modification of the surface of silica nanoparticles (SiO2) provides an opportunity for achieving stimulus-sensitive drug delivery system. Here, we have modified the surface of SiO2 using hydrogen bonding interactions by employing an aqueous two-phase system (ATPS) based on polyethylene glycol and lysine. This novel biocompatible ATPS provides an environment for simultaneous drug encapsulation, SiO2 modification, and drug partitioning in one pot. Addition of SiO2 to ATPS increased the partitioning of doxorubicin (DOX) as an anti-cancer drug from 47.92 in the absence of nanoparticles to 92.33 due to the interactions between drug and nanoparticles. The formation of nanoformulation and its characteristics were investigated applying microscopy, spectroscopy and thermal analysis. Drug release study demonstrated that DOX is loaded on nanoformulations efficiently with an encapsulation efficiency of 63.84% and shows lower release in physiological environment compared to the unmodified nanoparticles. While in acidic conditions of pH 5.5, significant increase was observed in the release profile. MTT assay on MCF-7 cancer cells confirmed that the nanoformulations were non-toxic and DOX-loaded nanocarrier showed anti-cancer behavior. These results indicate that the prepared nanoformulations are promising nanocarriers for controlled drug release purposes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Baghbanbashi¹,

Pazuki²,

Khoee³

2021

Preprint

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“…For example, self-assembled MMIAs can quench fluorescent tags located in the core of the nanoparticle, but these can become fluorescent again following disassembly as a result of protein-RNA binding or a pH change [58]. A recent study exploited the altered pH of tumor tissues to selectively release super-paramagnetic iron oxide nanoparticles for MRI following endosomal initialization [59]. (ii) Nonspecific binding: this can be a consequence of opsonization or of physiological effects such as the enhanced permeation and retention (EPR) effect [45] and enzymatic degradation [89].…”

Section: Biodegradation Of Mmiasmentioning

confidence: 99%

Multivalent Probes in Molecular Imaging: Reality or Future?

Böhmer

Szymański

Feringa

et al. 2021

Trends in Molecular Medicine

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Section: Charge Reversalmentioning

confidence: 99%

“…6.5-6.8). Following this approach, Wan et al coated the MSNs with highly cationic polyethyleneimine (PEI) through disulfide bonds, and masked the charges using citraconic anhydride [41] (Figure 6). The PEI coating was able to prevent premature drug release in the absence of GSH and, as observed in Figure 6, the internalization of the masked nanocarriers was much lower than those exposed to acid pH, obtaining high efficacy in vivo.…”

Section: Charge Reversalmentioning

confidence: 99%

Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates

Gisbert-Garzarán

Vallet‐Regí

2021

Nanomaterials

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Mesoporous silica nanoparticles have been widely applied as carriers for cancer treatment. Among the different types of stimuli-responsive drug delivery systems, those sensitive to redox stimuli have attracted much attention. Their relevance arises from the high concentration of reductive species that are found within the cells, compared to bloodstream, which leads to the drug release taking place only inside cells. This review is intended to provide a comprehensive overview of the most recent trends in the design of redox-responsive mesoporous silica nanoparticles. First, a general description of the biological rationale of this stimulus is presented. Then, the different types of gatekeepers that are able to open the pore entrances only upon application of reductive conditions will be introduced. In this sense, we will distinguish among those targeted and those non-targeted toward cancer cells. Finally, a new family of bridged silica nanoparticles able to degrade their structure upon application of this type of stimulus will be presented.

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A novel intratumoral pH/redox-dual-responsive nanoplatform for cancer MR imaging and therapy

Cited by 31 publications

References 46 publications

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

One Pot Doxorubicin Partitioning and Encapsulation on Silica Nanoparticle, Applying Aqueous Two Phase System for Preparation of pH-Responsive Nanocarriers

Multivalent Probes in Molecular Imaging: Reality or Future?

Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates

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