A novel innexin2 forming membrane hemichannel exhibits immune responses and cell apoptosis in Scylla paramamosain

Wang, Shuping; Chen, Fang-Yi; Dong, Lixia; Zhang, Yaqun; Chen, Huiyun; Qiao, Kun; Wang, Kejian

doi:10.1016/j.fsi.2015.09.028

Cited by 21 publications

(20 citation statements)

References 60 publications

(72 reference statements)

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“…Studies performed in Scylla paramamosain ( S. paramamosain ) have shown that channels formed by innexin are critical to the immune response (Wang et al, 2015 ). High levels of mRNA for Sp-inx2 were identified in hemocytes, which are major invertebrate innate immune cells (Wang et al, 2015 ).…”

Section: Innexin In the Immune Systemmentioning

confidence: 99%

Innexins: Expression, Regulation, and Functions

et al. 2018

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The innexin (Inx) proteins form gap junction channels and non-junctional channels (named hemichannels) in invertebrates. These channels participate in cellular communication playing a relevant role in several physiological processes. Pioneer studies conducted mainly in worms and flies have shown that innexins participate in embryo development and behavior. However, recent studies have elucidated new functions of innexins in Arthropoda, Nematoda, Annelida, and Cnidaria, such as immune response, and apoptosis. This review describes emerging data of possible new roles of innexins and summarizes the data available to date.

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Section: Innexin In the Immune Systemmentioning

confidence: 99%

Innexins: Expression, Regulation, and Functions

et al. 2018

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“…There are 21 innexin genes in P. vannamei [6], and some of them are due to the multiplication of the viral genome. Innexin is involved in immune response and cell apoptosis [65,66], probably by regulating the closure of the gap channel to reduce the neighboring cellular apoptosis [67,68]. In a study in red swamp crayfish, the innexin gene has been listed as a candidate anti-WSSV gene [57].…”

Section: Nimav-1_lva Genes Involved In Host-pathogen Interactionmentioning

confidence: 99%

The Complete Genome of an Endogenous Nimavirus (Nimav-1_LVa) From the Pacific Whiteleg Shrimp Penaeus (Litopenaeus) Vannamei

Bao

Tang

Alcivar–Warren³

2020

Genes

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White spot syndrome virus (WSSV), the lone virus of the genus Whispovirus under the family Nimaviridae, is one of the most devastating viruses affecting the shrimp farming industry. Knowledge about this virus, in particular, its evolution history, has been limited, partly due to its large genome and the lack of other closely related free-living viruses for comparative studies. In this study, we reconstructed a full-length endogenous nimavirus consensus genome, Nimav-1_LVa (279,905 bp), in the genome sequence of Penaeus (Litopenaeus) vannamei breed Kehai No. 1 (ASM378908v1). This endogenous virus seemed to insert exclusively into the telomeric pentanucleotide microsatellite (TAACC/GGTTA)n. It encoded 117 putative genes, with some containing introns, such as g012 (inhibitor of apoptosis, IAP), g046 (crustacean hyperglycemic hormone, CHH), g155 (innexin), g158 (Bax inhibitor 1 like). More than a dozen Nimav-1_LVa genes are involved in the pathogen-host interactions. We hypothesized that g046, g155, g158, and g227 (semaphorin 1A like) were recruited host genes for their roles in immune regulation. Sequence analysis indicated that a total of 43 WSSV genes belonged to the ancestral/core nimavirus gene set, including four genes reported in this study: wsv112 (dUTPase), wsv206, wsv226, and wsv308 (nucleocapsid protein). The availability of the Nimav-1_LVa sequence would help understand the genetic diversity, epidemiology, evolution, and virulence of WSSV.

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“…Dm-Inx2 e Dm-Inx3 participam da transmissão dos sinais bioelétricos durante a ovogênese (Lautemann, Bohrmann, 2016). Em Scylla paramamosain, Sp-Inx2 tem maior expressão em células do sistema imune (Wang et al, 2015).…”

Section: Revisão Da Literaturaunclassified

“…Como encontrado em outras proteínas de junção, como as claudinas e ocludinas, os domínios em alfa-hélice das conexinas e inexinas correspondem as regiões onde estão presente os domínios transmembrana (Hua et al, 2003). Os resultados mostram que a sequência consenso de Ra- (Ducret et al, 2016;Shrut et al, 2014;Wang et al, 2015). No geral, os resultados que adquirimos estão de acordo com o mesmo padrão filogenético apresentado na literatura (Hasegawa, Turnbull, 2014;Phelan, 2005).…”

Section: Níveis De Expressão Em Testículounclassified

See 1 more Smart Citation

Estudo da interação celular por meio da inexina-2 na formação das junções comunicantes em <i>Rhynchosciara americana</i>: uma abordagem morfológica e molecular.

Neves¹

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Aos meus amados pais Mirian e Erivelto, aos meus queridos irmãos Luciana e Gustavo e a minha amada noiva Geyssi por serem a maior prova do amor de Deus para mim. AGRADECIMENTOS À Deus principalmente por ser simplesmente um Pai de amor. Aos meus pais Mirian e Erivelto Neves por serem as pessoas que eu mais admiro, por sempre me incentivar e aconselhar, sem vocês eu não teria conseguido concluir este trabalho.

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A novel innexin2 forming membrane hemichannel exhibits immune responses and cell apoptosis in Scylla paramamosain

Cited by 21 publications

References 60 publications

Innexins: Expression, Regulation, and Functions

Innexins: Expression, Regulation, and Functions

The Complete Genome of an Endogenous Nimavirus (Nimav-1_LVa) From the Pacific Whiteleg Shrimp Penaeus (Litopenaeus) Vannamei

Estudo da interação celular por meio da inexina-2 na formação das junções comunicantes em <i>Rhynchosciara americana</i>: uma abordagem morfológica e molecular.

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