A novel infrared spectroscopic approach to study the interaction of amyloid-B with cell-penetrating peptides—a possible new class of drugs to combat Alzheimer's disease

Sabatier, Paul; Danilov, Artem; Gokus, Tobias; Barth, Andreas

doi:10.1016/j.bpj.2022.11.1228

Cited by 1 publication

(1 citation statement)

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“…Deep theoretical and experimental investigations allow a better understanding of carbohydrate structures and their specific interactions in various environments and self-assembling phenomena [16,27]. Modern techniques and new approaches are available for these studies, such as nuclear magnetic resonance (NMR) spectroscopy [27,28], atomic force microscopy (AFM) [29][30][31][32], infrared (IR) spectroscopy [33,34], liquid or gas chromatography [35][36][37][38], capillary electrophoresis [39][40][41], mass spectrometry [42][43][44], molecular modeling [31,45,46], or analytical techniques [47].…”

Section: Polysaccharides-from Structural Aspects To Multifunctional H...mentioning

confidence: 99%

Diversity of Bioinspired Hydrogels: From Structure to Applications

Lupu¹,

Grădinaru²,

Gradinaru

et al. 2023

Gels

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Hydrogels are three-dimensional networks with a variety of structures and functions that have a remarkable ability to absorb huge amounts of water or biological fluids. They can incorporate active compounds and release them in a controlled manner. Hydrogels can also be designed to be sensitive to external stimuli: temperature, pH, ionic strength, electrical or magnetic stimuli, specific molecules, etc. Alternative methods for the development of various hydrogels have been outlined in the literature over time. Some hydrogels are toxic and therefore are avoided when obtaining biomaterials, pharmaceuticals, or therapeutic products. Nature is a permanent source of inspiration for new structures and new functionalities of more and more competitive materials. Natural compounds present a series of physico-chemical and biological characteristics suitable for biomaterials, such as biocompatibility, antimicrobial properties, biodegradability, and nontoxicity. Thus, they can generate microenvironments comparable to the intracellular or extracellular matrices in the human body. This paper discusses the main advantages of the presence of biomolecules (polysaccharides, proteins, and polypeptides) in hydrogels. Structural aspects induced by natural compounds and their specific properties are emphasized. The most suitable applications will be highlighted, including drug delivery, self-healing materials for regenerative medicine, cell culture, wound dressings, 3D bioprinting, foods, etc.

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