A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells

Priyanga, J.; Kumar, Brijesh; Mahalakshmi, Radhakrishnan; Nirekshana, K.; Vinoth, Perumal; Sridharan, Vellaisamy; Bhakta-Guha, Dipita; Guha, Gunjan

doi:10.1016/j.cbi.2020.109250

Cited by 4 publications

(2 citation statements)

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“…P53 is a tumor suppressor gene and its expression level varies in various pathways of cell senescence induced by oxidative stress (Inao et al, 2019; Kim et al, 2021; Kumar et al, 2021). Accumulated evidences have established that the P53 and P53/P21 pathways play a significant effect during the aging process (Priyanga et al, 2020; Xin et al, 2019). The possible involvement of P53/P21pathways in progressive aging diseases has been the focus of a lot of studies in recent years (Bai et al, 2011; Niu et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Accumulated evidences have established that the P53 and P53/ P21 pathways play a significant effect during the aging process (Priyanga et al, 2020;Xin et al, 2019). The possible involvement of P53/P21pathways in progressive aging diseases has been the focus of a lot of studies in recent years (Bai et al, 2011;Niu et al, 2021).…”

Section: Dhp Affects Protein Levels In Brain and Liver Tissuementioning

confidence: 99%

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Protective effects of Dendrobium huoshanense polysaccharide on D‐gal induced PC12 cells and aging mice, in vitro and in vivo studies

Liu

Deng

et al. 2022

Journal of Food Biochemistry

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Dendrobium huoshanense C. Z. Tang et S. J. Cheng polysaccharide (DHP) is the essential active ingredient of D.huoshanense and has high medicinal value. A high dose of D‐galactose (D‐gal) is commonly utilized in the aging model establishment. In this study, we explored whether DHP shields PC12 cells and aging mice from D‐gal caused damage and the possible mechanism. In vitro experiments, D‐gal induced PC12 cells were used to investigate, and then DHP was used for treatment. In vivo experiments, 72 SPF ICR male mice were randomly divided into six groups (control: normal saline; model: D‐gal (400 mg/kg); VE group: VE (50 μg/ml); DHP groups: D‐gal + DHP (15.6 mg/ml; 31.2 mg/ml; 62.4 mg/ml)). The results showed that DHP could enhance the viability of D‐gal injured PC12 cells and prevent cell apoptosis. DHP effectively promoted the transition from phase G0/G1 to phase S and inhibited cell cycle arrest. DHP has a potential neuroprotective effect on D‐gal caused cognitive and memory disorders in mice. On the one hand, DHP protects the antioxidant enzymes SOD, GSH‐PX, and CAT from excessive ROS buildup. On the other hand, DHP was demonstrated to block the expression of the P53/P21 signaling pathway‐related proteins P53, P21, and P16. These results imply that DHP could be a potential neuroprotective agent against aging. Practical applications Cognitive and memory decline caused by aging problems has become a problem in recent years. There are many theories about aging, among which oxidative stress is considered to be one of the important pathophysiological parts of various diseases in the aging process. In this study, DHP could not only improve the damage of D‐Gal to PC12 cells, but also improve the cognitive and memory impairment caused by D‐Gal in mice. In conclusion, this study verified the anti‐aging effect of DHP from in vitro and in vivo experiments, and its mechanism may involve the P53/P21 pathway. Therefore, this study indicated that polysaccharides from Dendrobium huoshanense, a traditional Chinese medicine of homologous medicine and food, had potential and industrial value as potential anti‐aging drugs.

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