A novel immunogenic cell death-related genes signature for predicting prognosis, immune landscape and immunotherapy effect in hepatocellular carcinoma

Xu, Guangming; Jiang, Yifan; Li, Yu; Ge, Jiangzhen; Xu, Xiaofeng; Chen, Diyu; Wu, Jian

doi:10.1007/s00432-023-05370-1

Cited by 2 publications

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To explore the effect of breast cancer prognosis-related genes on tumor cell progression in the model, we selected the gene with the highest risk factor (HSP90AA1) for validation 26 . We observed the HSP90AA1 expression level in several breast cancer cells utilizing qRT-PCR and Western blot (Fig.…”

Section: Resultsmentioning

confidence: 99%

Immunogenic cell death-related classification reveals prognosis and effectiveness of immunotherapy in breast cancer

Zhu,

Wu,

Zhao

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Lack of specific biomarkers and effective drug targets constrains therapeutic research in breast cancer (BC). In this regard, therapeutic modulation of damage-associated molecular patterns (DAMPs)-induced immunogenic cell death (ICD) may help improve the effect of immunotherapy in individuals with BC. The aim of this investigation was to develop biomarkers for ICD and to construct ICD-related risk estimation models to predict prognosis and immunotherapy outcomes of BC. RNA-seq transcriptome information and medical data from individuals with BC (n = 943) were obtained from TCGA. Expression data from a separate BC cohort (GEO: GSE20685) were used for validation. We identified subtypes of high and low ICD gene expression by consensus clustering and assessed the connection between ICD subtypes and tumor microenvironment (TME). In addition, different algorithms were used to construct ICD-based prognostic models of BC. BC samples were categorized into subtypes of high and low ICD expression depending on the expression of genes correlated with ICD. The subtype of ICD high-expression subtypes are correlated with poor prognosis in breast cancer, while ICD low-expression subtypes may predict better clinical outcomes. We also created and verified a predictive signature model depending on four ICD-related genes (ATG5, CD8A, CD8B, and HSP90AA1), which correlates with TME status and predicts clinical outcomes of BC patients. We highlight the connection of ICD subtypes with the dynamic evolution of TME in BC and present a novel ICD-based prognostic model of BC. In clinical practice, distinction of ICD subtype and assessment of ICD-related biomarkers should help guide treatment planning and improve the effectiveness of tumor immunotherapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Immunogenic cell death-related classification reveals prognosis and effectiveness of immunotherapy in breast cancer

Zhu,

Wu,

Zhao

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

Immunogenic cell death signatures derived from on-treatment tumor specimens for predicting immune checkpoint blockade therapy response and prognosis in metastatic melanoma

Zeng,

Jiang,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

Melanoma is a highly malignant form of skin cancer that typically originates from abnormal melanocytes. Despite significant advances in treating metastatic melanoma with immune checkpoint blockade (ICB) therapy, a substantial number of patients do not respond to this treatment and face risks of recurrence and metastasis. This study collected data from multiple datasets, including cohorts from Riaz et al., Gide et al., MGH, and Abril-Rodriguez et al., focusing on on-treatment samples during ICB therapy. We used the single-sample gene set enrichment analysis (ssGSEA) method to calculate immunogenic cell death scores (ICDS) and employed an elastic network algorithm to construct a model predicting ICB efficacy. By analyzing 18 ICD gene signatures, we identified 9 key ICD gene signatures that effectively predict ICB treatment response for on-treatment metastatic melanoma specimens. Results showed that patients with high ICD scores had significantly higher response rates to ICB therapy compared to those with low ICD scores. ROC analysis demonstrated that the AUC values for both the training and validation sets were around 0.8, indicating good predictive performance. Additionally, survival analysis revealed that patients with high ICD scores had longer progression-free survival (PFS) and overall survival (OS). This study used an elastic network algorithm to identify 9 ICD gene signatures related to the immune response in metastatic melanoma. These gene features can not only predict the efficacy of ICB therapy but also provide references for clinical decision-making. The results indicate that ICD plays an important role in metastatic melanoma immunotherapy and that expressing ICD signatures can more accurately predict ICB treatment response and prognosis for on-treatment metastatic melanoma specimens, thus providing a basis for personalized treatment.

show abstract

A novel immunogenic cell death-related genes signature for predicting prognosis, immune landscape and immunotherapy effect in hepatocellular carcinoma

Cited by 2 publications

References 43 publications

Immunogenic cell death-related classification reveals prognosis and effectiveness of immunotherapy in breast cancer

Immunogenic cell death-related classification reveals prognosis and effectiveness of immunotherapy in breast cancer

Immunogenic cell death signatures derived from on-treatment tumor specimens for predicting immune checkpoint blockade therapy response and prognosis in metastatic melanoma

Contact Info

Product

Resources

About