A novel immunodeficiency syndrome as a rare cause of secondary pulmonary alveolar proteinosis: A diagnosis after 5 decades

A novel approach to the classification of epidermodysplasia verruciformis

“…Recent discoveries of novel genes associated with EV are classified under nonclassic genetic EV. These include RHOH, MST‐1, CORO1A, and ECM1 . Patients with nonclassic genetic EV have similar cutaneous lesions and histopathologic findings as those found in classic genetic EV.…”

“…Nonclassic genetic EV shares many similarities with its classic counterpart. An early age of symptom onset, a genetic component, and similar appearing lesions macroscopically and microscopically highlight the important similarities . However, while the EVER genes show a specific impairment in cell‐mediated immunity to HPV infection, the genes in nonclassic genetic EV often affect many immune pathways, leading to a broader scope of infection.…”

“…More recently, several other genes have been implicated in EV, including RHOH, MST‐1, CORO1A, and ECM1 . The patients with these genetic mutations share many similarities with classic EV patients, including the development of similar clinical symptoms at a young age and a susceptibility to specific HPV types due to impaired cell‐mediated immunity.…”