Abstract:Metabolic Syndrome X, characterized by insulin resistance, dyslipidemia, obesity, and hypertension, affects over 70 million Americans. Imidazoline drugs, such as moxonidine, are emerging therapeutic agents for conditions associated with Syndrome X. Studies from our laboratory showed a reduction in blood pressure when moxonidine was injected into the rostral ventrolateral medulla (RVLM) of spontaneously hypertensive rats (SHR). Moxonidine also activated the insulin signaling cascade and increased glucose uptake… Show more
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