A Novel Imidazole Bound Schiff Base as Highly Selective “Turn-on” Fluorescence Sensor for Zn2+ and Colorimetric Kit for Co2+

Gopalakrishnan, Anjali K.; Angamaly, Shanty Antony; Pradeep, Savitha D.; Madhusoodhanan, Dhanya Thaikatt; Manoharan, Divya Kizhakkeppurath; Mohanan, Pezholil

doi:10.1007/s10895-021-02839-5

Cited by 12 publications

(5 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a noticeable uorescence enhancement was observed when Zn 2+ or Al 3+ ions were added into the DMSO/H 2 O (9:1, v/v) solution of SHK, respectively. The weak uorescence in free SHK solution was due to the photoinduced electron transfer (PET) process involving lone pairs of electron N atoms, which blocked the radiation of the uorescent group [21][22][23][24][33][34]. The turn-on uorescence responses of SHK towards Zn 2+ and Al 3+ ions were ascribed to the inhibition of the PET process and the promotion of chelation-enhanced uorescence (CHEF) after binding to metal ions [21][22][23][24][33][34].…”

Section: Resultsmentioning

confidence: 99%

“…To determine the stoichiometric ratio of the probe SHK with Zn 2+ , Job-plots of SHK with Zn 2+ were calculated from the continuous variation of the uorescent emission intensity during the titration process [21][22][23][24]. A plot of uorescent intensity attained to a maximum at a molar ratio of ca.…”

Section: Resultsmentioning

confidence: 99%

“…Schiff bases, an essential class of uorescent sensors, feature multiple nitrogen-oxygen-rich coordination sites for chelation metal ions [18][19][20]. In common, the Schiff base derivatives display extremely weak uorescence due to the photo-induced electron transfer (PET) process and -C = N-isomerization [21]. In contrast, the uorescence intensity enhances drastically after coordinating with metal ions resulting from the inhibition of the PET process and the facilitation of the chelation-enhanced uorescence (CHEF) [22].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Fluorescent Probe Based on the Hydrazone Schiff Base for the Detection of Zn2+ and its Application on Test Strips

Zhang

et al. 2023

J Fluoresc

View full text Add to dashboard Cite

A novel uorescent probe SHK for Zn 2+ detection was designed based on the hydrazone Schiff base, successfully synthesized by Suzuki coupling and condensation reactions. The probe SHK in DMSO/H 2 O showed extremely weak uorescence. However, the solution exhibited an intensive yellow-green emission with the introduction of Zn 2+ . In contrast, negligible uorescence change was observed when other metal ions were added, suggesting a high selectivity of SHK for Zn 2+ detection. The Job's Plot analysis revealed that a 1:1 stoichiometric adduct SHK-Zn 2+ formed during the Zn 2+ sensing. The binding constant of the complex was determined to be 184 M − 1 , and the detection limit for Zn 2+ was calculated to be 112 µM.Moreover, the probe SHK achieved selective uorescence sensing for Zn 2+ on test strips, which guaranteed its practical application prospect.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Fluorescent Probe Based on the Hydrazone Schiff Base for the Detection of Zn2+ and its Application on Test Strips

Zhang

et al. 2023

J Fluoresc

View full text Add to dashboard Cite

show abstract

“…In the presence of Zn (II) ions, measurable fluorescence signals were generated at 612 nm, accompanied with bath color enhancement. The sensitivity of the fluorescence method for the determination of Zn (II) ions (6.78 × 10 −9 M) was far lower than the World Health Organization’s drinking water guidelines (7.6 × 10 −5 M), so it could become a practical system for monitoring the concentration of Zn (II) ions in water samples [ 505 ].…”

Section: Imidazole-based Supermolecules As Pathological Probesmentioning

confidence: 99%

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Tan

Zhang

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily bind with various inorganic or organic ions and molecules through noncovalent interactions to form a variety of supramolecular complexes with broad medicinal potential, which is being paid an increasing amount of attention regarding more and more contributions to imidazole-based supramolecular complexes for possible medicinal application. This work gives systematical and comprehensive insights into medicinal research on imidazole-based supramolecular complexes, including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and anti-inflammatory aspects as well as ion receptors, imaging agents, and pathologic probes. The new trend of the foreseeable research in the near future toward imidazole-based supramolecular medicinal chemistry is also prospected. It is hoped that this work provides beneficial help for the rational design of imidazole-based drug molecules and supramolecular medicinal agents and more effective diagnostic agents and pathological probes.

show abstract

“…(m) A reversible naphthalimide-based probe detected Hg (II) ions in a phosphate buffer over a wide pH range (7.0–10.0), which is highly applicable in biological experiments [ 63 ]. (n) Imidazolyl Schiff bases exhibit Zn (II) detection as low as 6.78 × 10 −9 M compared to the recommended sensitivity detection according to the World Health Organization’s drinking water guidelines (7.6 × 10 −5 M) [ 64 ]. (o) Imidazole-based anthracene structure detection limit of Zn (II): 1.0 × 10 −9 M [ 65 ].…”

Section: Introductionmentioning

confidence: 99%

Imidazoles as Serotonin Receptor Modulators for Treatment of Depression: Structural Insights and Structure–Activity Relationship Studies

Goel,

Thapliyal,

Kharb

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Serotoninergic signaling is identified as a crucial player in psychiatric disorders (notably depression), presenting it as a significant therapeutic target for treating such conditions. Inhibitors of serotoninergic signaling (especially selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI)) are prominently selected as first-line therapy for the treatment of depression, which benefits via increasing low serotonin levels and norepinephrine by blocking serotonin/norepinephrine reuptake and thereby increasing activity. While developing newer heterocyclic scaffolds to target/modulate the serotonergic systems, imidazole-bearing pharmacophores have emerged. The imidazole-derived pharmacophore already demonstrated unique structural characteristics and an electron-rich environment, ultimately resulting in a diverse range of bioactivities. Therefore, the current manuscript discloses such a specific modification and structural activity relationship (SAR) of attempted derivatization in terms of the serotonergic efficacy of the resultant inhibitor. We also featured a landscape of imidazole-based development, focusing on SAR studies against the serotoninergic system to target depression. This study covers the recent advancements in synthetic methodologies for imidazole derivatives and the development of new molecules having antidepressant activity via modulating serotonergic systems, along with their SAR studies. The focus of the study is to provide structural insights into imidazole-based derivatives as serotonergic system modulators for the treatment of depression.

show abstract

A Novel Imidazole Bound Schiff Base as Highly Selective “Turn-on” Fluorescence Sensor for Zn2+ and Colorimetric Kit for Co2+

Cited by 12 publications

References 43 publications

A Fluorescent Probe Based on the Hydrazone Schiff Base for the Detection of Zn2+ and its Application on Test Strips

A Fluorescent Probe Based on the Hydrazone Schiff Base for the Detection of Zn2+ and its Application on Test Strips

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Imidazoles as Serotonin Receptor Modulators for Treatment of Depression: Structural Insights and Structure–Activity Relationship Studies

Contact Info

Product

Resources

About