A Novel
            <i>Alteromonas</i>
            Phage Lineage with a Broad Host Range and Small Burst Size

Yang, Yue; Ma, Ruijie; Ye, Junlei; Chen, Xiaowei; Wang, Long; Jiao, Nianzhi; Zhang, Rui

doi:10.1128/spectrum.01499-22

Cited by 11 publications

(12 citation statements)

References 66 publications

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“…In this study, we reported the isolation and complete genome sequence of a filamentous phage designated ϕAFP1 from the South China Sea using the A. abrolhosensis strain JKT1 as the host bacterium. Until now, only 10 published reports about bacteriophages isolated from Alteromonas were available, including Siphoviridae phages PB15, JH01, P24, XX1924, and R7M and R9Y-phages ( 25 – 29 ), Myoviridae phage V22 ( 30 ), Podoviridiae phages altaD45 P1 to P4 ( 31 ) and Mareflavirus phage ZP6 ( 32 ), Autographiviridae phages H4/4’ ( 33 ) and R8W ( 34 ). Different from the above phages, ϕAFP1 consisted of a flexible filament (width = 10 nm, length = 900 nm), suggesting that this phage was a member of the family Inoviridae .…”

Section: Discussionmentioning

confidence: 99%

A Novel Inovirus Reprograms Metabolism and Motility of Marine Alteromonas

et al. 2022

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Section: Discussionmentioning

confidence: 99%

A Novel Inovirus Reprograms Metabolism and Motility of Marine Alteromonas

et al. 2022

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“…[28]) but also acknowledge that virulent phages can have a very small burst size on certain hosts (e.g. [29][30][31]). The parameter ranges for the plasmid conjugation rates and plasmid fitness effects were chosen in line with two meta-analysis on those two respective parameters [1,32].…”

Section: Methodsmentioning

confidence: 99%

My host’s enemy is my enemy: plasmids carrying CRISPR-Cas as a defence against phages

Siedentop,

Rüegg,

Bonhoeffer

et al. 2023

Preprint

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Bacteria are infected by mobile genetic elements like plasmids and virulent phages, and those infections significantly impact bacterial ecology and evolution. Recent discoveries reveal that some plasmids carry anti-phage immune systems like CRISPR-Cas, suggesting that plasmids may participate in the coevolutionary arms-race between virulent phages and bacteria. Intuitively, this seems reasonable as virulent phages kill the plasmid’s obligate host. However, the efficiency of CRISPR-Cas systems carried by plasmids can be expected to be lower than those carried by the chromosome due to continuous segregation loss, creating susceptible cells for phage amplification. To evaluate the anti-phage protection efficiency of CRISPR-Cas on plasmids, we develop a stochastic model describing the dynamics of a virulent phage infection against which a conjugative plasmid defends using CRISPR-Cas. We show that CRISPR-Cas on plasmids provides robust protection, except in limited parameter-sets. In these cases, high segregation favours phage outbreaks by generating a population of defenceless cells on which the phage can evolve and escape CRISPR-Cas immunity. We show that the phage’s ability to exploit segregation loss depends strongly on the evolvability of both CRISPR-Cas and the phage itself.

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“…[28]) but also acknowledges that virulent phages can have a very small burst size on certain hosts (e.g. [29][30][31]).…”

Section: E) Implementationmentioning

confidence: 99%

My host’s enemy is my enemy: plasmids carrying CRISPR-Cas as a defence against phages

Siedentop,

Rüegg,

Bonhoeffer

et al. 2024

Proc. R. Soc. B.

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Bacteria are infected by mobile genetic elements like plasmids and virulent phages, and those infections significantly impact bacterial ecology and evolution. Recent discoveries reveal that some plasmids carry anti-phage immune systems like CRISPR-Cas, suggesting that plasmids may participate in the coevolutionary arms race between virulent phages and bacteria. Intuitively, this seems reasonable as virulent phages kill the plasmid’s obligate host. However, the efficiency of CRISPR-Cas systems carried by plasmids can be expected to be lower than those carried by the chromosome due to continuous segregation loss, creating susceptible cells for phage amplification. To evaluate the anti-phage protection efficiency of CRISPR-Cas on plasmids, we develop a stochastic model describing the dynamics of a virulent phage infection against which a conjugative plasmid defends using CRISPR-Cas. We show that CRISPR-Cas on plasmids provides robust protection, except in limited parameter sets. In these cases, high segregation loss favours phage outbreaks by generating a population of defenceless cells on which the phage can evolve and escape CRISPR-Cas immunity. We show that the phage’s ability to exploit segregation loss depends strongly on the evolvability of both CRISPR-Cas and the phage itself.

show abstract

A Novel Alteromonas Phage Lineage with a Broad Host Range and Small Burst Size

Cited by 11 publications

References 66 publications

A Novel Inovirus Reprograms Metabolism and Motility of Marine Alteromonas

A Novel Inovirus Reprograms Metabolism and Motility of Marine Alteromonas

My host’s enemy is my enemy: plasmids carrying CRISPR-Cas as a defence against phages

My host’s enemy is my enemy: plasmids carrying CRISPR-Cas as a defence against phages

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