A novel hydrate of α-cyclodextrin crystallised under high-pressure conditions

Structural Elucidation of α-Cyclodextrin-Succinic Acid Pseudo Dodecahydrate: Expanding the Packing Types of α-Cyclodextrin Inclusion Complexes

“…In a second set of experiments, a single crystal of the α-CD¨SA complex crystallized at ambient-pressure conditions was loaded in a DAC together with either its mother liquor or water. Pressure was increased and gradual dissolution of the crystal was observed, similar to what was reported for pure α-CD hydrate form I [9]. Subsequent to dissolution, no crystallization event was recorded.…”

“…The work presented here is part of ongoing investigations of cyclodextrin inclusion complex and hydrate formation at both ambient-and high-pressure crystallization conditions using water as crystallization medium [9]. α-CD (Figure 1), the smallest natural cyclic oligosaccharide with six sugar units, was chosen for studying inclusion complex formation with small molecules (here defined as molecules with a molecular weight <500 Daltons), particularly to compare and contrast the effects of non-ambient (low-temperature and high-pressure) crystallization conditions on complex formation.…”

Pressure inverse solubility and polymorphism of an edible γ-cyclodextrin-based metal–organic framework

“…However, it is characteristic of transforming MOFs that some transport of guest molecules will be involved, and such different MOF structures are treated as polymorphs. 24,25 The cubic form a of the space group I432 is retained during the compression up to at least 1.76 GPa, when the crystal dissolves (Fig. 7).…”

Multicomponent organic crystals at high pressure

“…Solvation -desolvation on compression and decompression is a promising topic that awaits a systematic research. The first examples of studies in this direction show already that high-pressure seems to favour the formation of solvates [63,[103][104][105][106][107][108][109], even of those compounds that were never obtained as solvates at ambient pressure, for example of L-alanine [63]. Very high degrees of hydration were reported for the high-pressure phases of some molecular compounds, such as GABA [107], or 1,4-diazabicyclo[2.2.2]octane hydroiodine [108].…”