A novel hybridization capture method for direct whole genome sequencing of clinical specimens to inform Legionnaires’ disease investigations
Phillip Weeber,
Navjot Singh,
Pascal Lapierre
et al.
Abstract:The unprecedented precision and resolution of whole genome sequencing (WGS) can provide definitive identification of infectious agents for epidemiological outbreak tracking. WGS approaches, however, are frequently impeded by low pathogen DNA recovery from available primary specimens or unculturable samples. A cost-effective hybrid capture assay for
Legionella pneumophila
WGS analysis directly on primary specimens was developed. DNA from a diverse range of sputum and autopsy specimen… Show more
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