A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells
Yasuteru Inoue,
Yingxue Ren,
Shuwen Zhang
et al.
Abstract:The maturation of brain microvascular endothelial cells leads to the formation of a tightly sealed monolayer, known as the blood–brain barrier (BBB). The BBB damage is associated with the pathogenesis of age-related neurodegenerative diseases including vascular cognitive impairment and Alzheimer’s disease. Growing knowledge in the field of epigenetics can enhance the understanding of molecular profile of the BBB and has great potential for the development of novel therapeutic strategies or targets to repair a … Show more
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