A novel highly divergent enteric calicivirus in a bovine calf, India

Abstract

In 2015, a novel highly divergent bovine calicivirus was detected in an Indian calf with enteritis. Phylogenetic analysis linked it to theNeboviruswith only 38.5% sequence identities, emphasizing the need for separate taxonomic classification. Furthermore, PCR screening detected these unique caliciviruses widely in India’s northern states.

Comprehensive Genomics Investigation of Neboviruses Reveals Distinct Codon Usage Patterns and Host Specificity

“…Nonetheless, among the enteric viruses, Neboviruses (NeVs), which primarily cause calf diarrhea, have created more interest among the research community because of their huge genetic diversity and widespread geographical distribution. Till now, NeVs have been identified in more than 14 countries [4,9,14,15,[22][23][24][25][26][27]. Furthermore, our previous study confirmed the presence of NeVs in the Indian bovine population and whole-genome characterization revealed a highly divergent NeV strain [27].…”

“…Till now, NeVs have been identified in more than 14 countries [4,9,14,15,[22][23][24][25][26][27]. Furthermore, our previous study confirmed the presence of NeVs in the Indian bovine population and whole-genome characterization revealed a highly divergent NeV strain [27]. Despite the huge genetic diversity and widespread geographical distribution of NeVs, a detailed dissection of factors governing the NeVs' evolution, particularly host-driven evolutionary pressures, as well as their codon usage preferences, has not been performed so far.…”