A novel gyrovirus in a common pheasant (Phasianus colchicus) with poult enteritis and mortality syndrome

Fehér, Enikő; Bali, Krisztina; Kaszab, Eszter; Ihász, Katalin; Jakab, Szilvia; Nagy, Blaise; Ursu, Krisztina; Farkas, Szilvia L.; Bányai, Krisztiàn

doi:10.1007/s00705-022-05417-7

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…In recent years, other circoviruses have been reported, and several species have been shown to be pathogenic to poultry ( Truchado et al, 2019 ; Feher et al, 2022 ; Yan et al, 2023 ). Yang et al found that GyH1 and CAV synergistically promote immunosuppression, pathogenicity, and viral replication in co-infected chicken, highlighting the interaction between CAV and GyH1 in the disease process and increasing potential health risk in the poultry breeding industry ( Yang et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

“…Before 2011, chicken infectious anemia virus ( CAV ) was the only member of the genus Gyrovirus within the family Circoviridae, which is responsible for severe anemia and immunosuppression in young susceptible chickens, and was one of the most important pathogens affecting the poultry industry and the SPF breeding industry ( Rijsewijk et al, 2011 ). Since 2011, a series of circovirus sequences similar to CAV (HGyV/AGV2, GyV3 through GyV13) have been reported ( Sauvage et al, 2011 ; Chu et al, 2012 ; Niu et al, 2019 ; Feher et al, 2022 ; Ji et al, 2022 ). These viruses have been identified in birds (chicken, northern fulmar, crested screamer, ashy storm petrel, ferruginous-backed antbird, white-plumed antbird, grey teal, pigeon, Pekin duck), mammals (human, cat, dog, ferret, mice) and reptiles (king rat snake) ( Feher et al, 2014 ; Truchado et al, 2019 ; Wu et al, 2019 ; Ji et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and phylogenetic analysis of Gyrovirus galga 1 in southern China from 2020 to 2022

Zhang,

Xie,

Yang

et al. 2024

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and phylogenetic analysis of Gyrovirus galga 1 in southern China from 2020 to 2022

Zhang,

Xie,

Yang

et al. 2024

Poultry Science

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“…Genetic variability was demonstrated among sequences with a range of sequence identity of 92% to 97% when analyzing the VP1 gene. This level of sequence divergence may suggest that pheasants serve as true host species for the identified gyrovirus species, tentatively called Gyrovirus phaco 1 [17].…”

Section: Discussionmentioning

confidence: 99%

“…In some years, several pools were tested in parallel from the same locations (Table 1). In general, 89,199,122 reads were generated for these 20 samples using next-generation sequencing in a range of 1,419,265 to 17,507,704 sequence reads for each sample; of these, the specimen with the largest sequence data was available from a previous report and was reanalyzed in this study [17]. Sequence reads were analyzed using four metagenomic classifiers: Kraken, Kaiju, Centrifuge, and Virmine.…”

Section: Viral Flora Of the Pheasant Intestinementioning

confidence: 99%

Metagenomic Identification of Novel Eukaryotic Viruses with Small DNA Genomes in Pheasants

Kaszab,

Bali,

Marton

et al. 2024

Animals

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A panel of intestinal samples collected from common pheasants (Phasianus colchicus) between 2008 and 2017 was used for metagenomic investigation using an unbiased enrichment protocol and different bioinformatic pipelines. The number of sequence reads in the metagenomic analysis ranged from 1,419,265 to 17,507,704 with a viral sequence read rate ranging from 0.01% to 59%. When considering the sequence reads of eukaryotic viruses, RNA and DNA viruses were identified in the samples, including but not limited to coronaviruses, reoviruses, parvoviruses, and CRESS DNA viruses (i.e., circular Rep-encoding single-stranded DNA viruses). Partial or nearly complete genome sequences were reconstructed of at least three different parvoviruses (dependoparvovirus, aveparvovirus and chaphamaparvovirus), as well as gyroviruses and diverse CRESS DNA viruses. Generating information of virus diversity will serve as a basis for developing specific diagnostic tools and for structured epidemiological investigations, useful to assess the impact of these novel viruses on animal health.

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“…CAV is found worldwide and causes significant mortality among chicks not protected by maternal antibodies. Other gyroviruses have been identified in diseased avian hosts, including in seabirds (15–19). Herein, we describe a new gyrovirus associated with RDS in yellow-eyed penguins.…”

Section: Introductionmentioning

confidence: 99%

A novel gyrovirus associated with a fatal respiratory disease in yellow-eyed penguin (Megadyptes antipodes) chicks

Wierenga

Morgan

Hunter

et al. 2022

Preprint

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Yellow-eyed penguins (Megadyptes antipodes), or hoiho in te reo Māori, are predicted to become extinct on mainland Aotearoa New Zealand in the next few decades, with infectious disease a significant contributor to their decline. A recent disease phenomenon termed respiratory distress syndrome (RDS) causing lung pathology has been identified in very young chicks. To date, no causative pathogens for RDS have been identified. In 2020 and 2021, the number of chick deaths from suspected RDS increased four- and five-fold, respectively, with a mortality rate of >90%. Here, we aimed to identify possible pathogens responsible for RDS disease impacting yelloweyed penguins. Total RNA was extracted from tissue samples collected during post-mortem of 43 chicks and subject to metatranscriptomic sequencing. From these data we identified a novel and highly abundant gyrovirus in 80% of tissue samples. This virus exhibited only 41% amino acid identity within VP1 to its closest relative, Gyrovirus 8, discovered in a diseased seabird. No other exogenous viral transcripts, nor pathogenic bacterial, protozoal and fungal organisms, were identified in these tissues. Due to the high relative abundance of viral reads, it is likely that this novel gyrovirus is associated with RDS in yellow-eyed penguin chicks.Author SummaryNew Zealand’s population of yellow-eyed penguins, also called hoiho, are predicted to become extinct in the next 20-30 years, with disease a major factor contributing to their decline. A new disease, causing fluid and bleeding into the lungs, was initially identified in 2019 in very young chicks. It was characterised as causing respiratory distress with a mortality of >90% usually within the first week of life. To date, no causative pathogens of the disease have been identified. We aimed to identify possible pathogens responsible for respiratory disease in these penguin chicks. A metatranscriptomic survey of dead chicks identified a novel and highly abundant gyrovirus present in diseased tissue, with closely related viruses causing disease in other avian hosts. It is, therefore, highly likely that this novel gyrovirus is associated with respiratory disease in these chicks. This finding offers the potential to increase the success of disease management in the critically endangered yellow-eyed penguin and possibly other at-risk penguin species. The potential to lessen mortality and slow the decline of the species is essential in protecting the biodiversity of New Zealand’s fauna and flora.

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A novel gyrovirus in a common pheasant (Phasianus colchicus) with poult enteritis and mortality syndrome

Cited by 5 publications

References 33 publications

Prevalence and phylogenetic analysis of Gyrovirus galga 1 in southern China from 2020 to 2022

Prevalence and phylogenetic analysis of Gyrovirus galga 1 in southern China from 2020 to 2022

Metagenomic Identification of Novel Eukaryotic Viruses with Small DNA Genomes in Pheasants

A novel gyrovirus associated with a fatal respiratory disease in yellow-eyed penguin (Megadyptes antipodes) chicks

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